| Full name: hyaluronidase 1 | Alias Symbol: LUCA1|HYAL-1 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 3373 | HGNC ID: HGNC:5320 | Ensembl Gene: ENSG00000114378 | OMIM ID: 607071 |
| Drug and gene relationship at DGIdb | |||
Expression of HYAL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HYAL1 | 3373 | 210619_s_at | -0.0992 | 0.9229 | |
| GSE20347 | HYAL1 | 3373 | 210619_s_at | 0.1094 | 0.4778 | |
| GSE23400 | HYAL1 | 3373 | 210619_s_at | -0.1308 | 0.0971 | |
| GSE26886 | HYAL1 | 3373 | 210619_s_at | 0.9054 | 0.0003 | |
| GSE29001 | HYAL1 | 3373 | 210619_s_at | 0.0687 | 0.8635 | |
| GSE38129 | HYAL1 | 3373 | 210619_s_at | -0.2392 | 0.1758 | |
| GSE45670 | HYAL1 | 3373 | 210619_s_at | 0.2995 | 0.2766 | |
| GSE53622 | HYAL1 | 3373 | 54089 | -2.2020 | 0.0000 | |
| GSE53624 | HYAL1 | 3373 | 54089 | -2.2146 | 0.0000 | |
| GSE63941 | HYAL1 | 3373 | 210619_s_at | 1.0491 | 0.2205 | |
| GSE77861 | HYAL1 | 3373 | 210619_s_at | 0.7096 | 0.0008 | |
| GSE97050 | HYAL1 | 3373 | A_23_P69329 | -0.4776 | 0.1439 | |
| SRP007169 | HYAL1 | 3373 | RNAseq | 1.6596 | 0.0151 | |
| SRP064894 | HYAL1 | 3373 | RNAseq | 0.3269 | 0.2285 | |
| SRP133303 | HYAL1 | 3373 | RNAseq | 0.0388 | 0.9311 | |
| SRP159526 | HYAL1 | 3373 | RNAseq | 0.6805 | 0.2822 | |
| SRP193095 | HYAL1 | 3373 | RNAseq | -0.5021 | 0.1556 | |
| SRP219564 | HYAL1 | 3373 | RNAseq | -0.4207 | 0.5233 | |
| TCGA | HYAL1 | 3373 | RNAseq | -0.7787 | 0.0002 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by HYAL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HYAL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HYAL1 | 3373 | 0 | 18 | 12 | |
| GSE20123 | HYAL1 | 3373 | 0 | 19 | 11 | |
| GSE43470 | HYAL1 | 3373 | 0 | 19 | 24 | |
| GSE46452 | HYAL1 | 3373 | 2 | 16 | 41 | |
| GSE47630 | HYAL1 | 3373 | 1 | 24 | 15 | |
| GSE54993 | HYAL1 | 3373 | 6 | 2 | 62 | |
| GSE54994 | HYAL1 | 3373 | 1 | 33 | 19 | |
| GSE60625 | HYAL1 | 3373 | 5 | 0 | 6 | |
| GSE74703 | HYAL1 | 3373 | 0 | 15 | 21 | |
| GSE74704 | HYAL1 | 3373 | 0 | 12 | 8 | |
| TCGA | HYAL1 | 3373 | 0 | 78 | 18 |
Total number of gains: 15; Total number of losses: 236; Total Number of normals: 237.
Somatic mutations of HYAL1:
Generating mutation plots.
Highly correlated genes for HYAL1:
Showing top 20/184 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HYAL1 | FAM163B | 0.805969 | 3 | 0 | 3 |
| HYAL1 | KRTAP20-1 | 0.799479 | 3 | 0 | 3 |
| HYAL1 | OR10G8 | 0.783165 | 3 | 0 | 3 |
| HYAL1 | OR2Z1 | 0.782237 | 3 | 0 | 3 |
| HYAL1 | BARHL2 | 0.780352 | 3 | 0 | 3 |
| HYAL1 | RNF151 | 0.757237 | 3 | 0 | 3 |
| HYAL1 | OTOP3 | 0.754032 | 3 | 0 | 3 |
| HYAL1 | HES5 | 0.753242 | 3 | 0 | 3 |
| HYAL1 | MFSD2B | 0.751299 | 3 | 0 | 3 |
| HYAL1 | LINC01141 | 0.750323 | 3 | 0 | 3 |
| HYAL1 | TEN1 | 0.747131 | 3 | 0 | 3 |
| HYAL1 | CDRT15 | 0.744514 | 3 | 0 | 3 |
| HYAL1 | TMPRSS11A | 0.742516 | 3 | 0 | 3 |
| HYAL1 | RNF222 | 0.738481 | 3 | 0 | 3 |
| HYAL1 | CMTM1 | 0.725843 | 3 | 0 | 3 |
| HYAL1 | NCCRP1 | 0.724111 | 3 | 0 | 3 |
| HYAL1 | GPX6 | 0.712969 | 3 | 0 | 3 |
| HYAL1 | SNAI2 | 0.710488 | 4 | 0 | 4 |
| HYAL1 | KPRP | 0.710266 | 3 | 0 | 3 |
| HYAL1 | NOTO | 0.708194 | 3 | 0 | 3 |
For details and further investigation, click here
