| Full name: pyridoxal kinase | Alias Symbol: PNK|PKH|FLJ21324|PRED79|FLJ31940|MGC15873 | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 8566 | HGNC ID: HGNC:8819 | Ensembl Gene: ENSG00000160209 | OMIM ID: 179020 |
| Drug and gene relationship at DGIdb | |||
Expression of PDXK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDXK | 8566 | 202671_s_at | 0.7842 | 0.1447 | |
| GSE20347 | PDXK | 8566 | 218019_s_at | -0.2628 | 0.3085 | |
| GSE23400 | PDXK | 8566 | 218019_s_at | -0.0346 | 0.6977 | |
| GSE26886 | PDXK | 8566 | 218018_at | -0.2126 | 0.4398 | |
| GSE29001 | PDXK | 8566 | 218018_at | -0.1242 | 0.8020 | |
| GSE38129 | PDXK | 8566 | 202671_s_at | 0.0755 | 0.7126 | |
| GSE45670 | PDXK | 8566 | 202671_s_at | 0.3614 | 0.0744 | |
| GSE53622 | PDXK | 8566 | 12698 | -0.2821 | 0.0068 | |
| GSE53624 | PDXK | 8566 | 12698 | -0.3102 | 0.0000 | |
| GSE63941 | PDXK | 8566 | 202671_s_at | 0.8103 | 0.2252 | |
| GSE77861 | PDXK | 8566 | 218019_s_at | -0.3423 | 0.1219 | |
| GSE97050 | PDXK | 8566 | A_23_P68730 | 0.0694 | 0.7317 | |
| SRP007169 | PDXK | 8566 | RNAseq | -1.3924 | 0.0001 | |
| SRP008496 | PDXK | 8566 | RNAseq | -1.1825 | 0.0000 | |
| SRP064894 | PDXK | 8566 | RNAseq | 0.3979 | 0.1147 | |
| SRP133303 | PDXK | 8566 | RNAseq | -0.4455 | 0.0019 | |
| SRP159526 | PDXK | 8566 | RNAseq | -0.4404 | 0.0481 | |
| SRP193095 | PDXK | 8566 | RNAseq | -0.1857 | 0.0674 | |
| SRP219564 | PDXK | 8566 | RNAseq | 0.3988 | 0.3844 | |
| TCGA | PDXK | 8566 | RNAseq | -0.1693 | 0.0023 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PDXK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDXK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDXK | 8566 | 2 | 8 | 20 | |
| GSE20123 | PDXK | 8566 | 2 | 8 | 20 | |
| GSE43470 | PDXK | 8566 | 0 | 13 | 30 | |
| GSE46452 | PDXK | 8566 | 1 | 21 | 37 | |
| GSE47630 | PDXK | 8566 | 6 | 17 | 17 | |
| GSE54993 | PDXK | 8566 | 8 | 1 | 61 | |
| GSE54994 | PDXK | 8566 | 4 | 8 | 41 | |
| GSE60625 | PDXK | 8566 | 0 | 0 | 11 | |
| GSE74703 | PDXK | 8566 | 0 | 10 | 26 | |
| GSE74704 | PDXK | 8566 | 1 | 4 | 15 | |
| TCGA | PDXK | 8566 | 7 | 40 | 49 |
Total number of gains: 31; Total number of losses: 130; Total Number of normals: 327.
Somatic mutations of PDXK:
Generating mutation plots.
Highly correlated genes for PDXK:
Showing top 20/164 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDXK | ZBTB42 | 0.707436 | 3 | 0 | 3 |
| PDXK | MFSD5 | 0.664157 | 3 | 0 | 3 |
| PDXK | ICOSLG | 0.643306 | 3 | 0 | 3 |
| PDXK | CCDC137 | 0.640691 | 3 | 0 | 3 |
| PDXK | CACNB3 | 0.639175 | 3 | 0 | 3 |
| PDXK | SERPINB8 | 0.632792 | 4 | 0 | 4 |
| PDXK | AMBP | 0.629385 | 4 | 0 | 4 |
| PDXK | FDXR | 0.624304 | 3 | 0 | 3 |
| PDXK | P4HB | 0.623605 | 4 | 0 | 3 |
| PDXK | FGF11 | 0.62308 | 3 | 0 | 3 |
| PDXK | S100A2 | 0.621795 | 4 | 0 | 4 |
| PDXK | ESRP1 | 0.621138 | 4 | 0 | 4 |
| PDXK | SFN | 0.62057 | 6 | 0 | 5 |
| PDXK | MARK4 | 0.611456 | 3 | 0 | 3 |
| PDXK | CAPG | 0.610943 | 6 | 0 | 6 |
| PDXK | DNAJC5 | 0.609697 | 3 | 0 | 3 |
| PDXK | TSNAXIP1 | 0.608886 | 3 | 0 | 3 |
| PDXK | POLR2A | 0.604325 | 4 | 0 | 4 |
| PDXK | TMEM51 | 0.601663 | 7 | 0 | 6 |
| PDXK | SECTM1 | 0.600257 | 3 | 0 | 3 |
For details and further investigation, click here
