| Full name: iduronidase alpha-L- | Alias Symbol: MPS1|MPSI | ||
| Type: protein-coding gene | Cytoband: 4p16.3 | ||
| Entrez ID: 3425 | HGNC ID: HGNC:5391 | Ensembl Gene: ENSG00000127415 | OMIM ID: 252800 |
Expression of IDUA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IDUA | 3425 | 205059_s_at | -0.0322 | 0.9603 | |
| GSE20347 | IDUA | 3425 | 205059_s_at | -0.2730 | 0.1629 | |
| GSE23400 | IDUA | 3425 | 205059_s_at | -0.1361 | 0.0148 | |
| GSE26886 | IDUA | 3425 | 213723_s_at | 0.1323 | 0.2196 | |
| GSE29001 | IDUA | 3425 | 205059_s_at | -0.1358 | 0.5388 | |
| GSE38129 | IDUA | 3425 | 205059_s_at | -0.2527 | 0.0833 | |
| GSE45670 | IDUA | 3425 | 205059_s_at | 0.0144 | 0.9314 | |
| GSE53622 | IDUA | 3425 | 89072 | 0.1722 | 0.0017 | |
| GSE53624 | IDUA | 3425 | 89072 | 0.0750 | 0.2533 | |
| GSE63941 | IDUA | 3425 | 213723_s_at | 0.2715 | 0.0913 | |
| GSE77861 | IDUA | 3425 | 213723_s_at | -0.0089 | 0.9630 | |
| GSE97050 | IDUA | 3425 | A_33_P3392087 | 0.2442 | 0.2622 | |
| SRP007169 | IDUA | 3425 | RNAseq | -0.8990 | 0.1189 | |
| SRP064894 | IDUA | 3425 | RNAseq | 0.5840 | 0.0326 | |
| SRP133303 | IDUA | 3425 | RNAseq | -0.5258 | 0.0258 | |
| SRP159526 | IDUA | 3425 | RNAseq | -0.2372 | 0.5541 | |
| SRP193095 | IDUA | 3425 | RNAseq | 0.3562 | 0.1742 | |
| SRP219564 | IDUA | 3425 | RNAseq | 0.3991 | 0.3083 | |
| TCGA | IDUA | 3425 | RNAseq | -0.3914 | 0.0005 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IDUA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IDUA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IDUA | 3425 | 0 | 17 | 13 | |
| GSE20123 | IDUA | 3425 | 0 | 15 | 15 | |
| GSE43470 | IDUA | 3425 | 0 | 17 | 26 | |
| GSE46452 | IDUA | 3425 | 1 | 36 | 22 | |
| GSE47630 | IDUA | 3425 | 2 | 19 | 19 | |
| GSE54993 | IDUA | 3425 | 11 | 0 | 59 | |
| GSE54994 | IDUA | 3425 | 3 | 12 | 38 | |
| GSE60625 | IDUA | 3425 | 0 | 0 | 11 | |
| GSE74703 | IDUA | 3425 | 0 | 13 | 23 | |
| GSE74704 | IDUA | 3425 | 0 | 8 | 12 | |
| TCGA | IDUA | 3425 | 9 | 47 | 40 |
Total number of gains: 26; Total number of losses: 184; Total Number of normals: 278.
Somatic mutations of IDUA:
Generating mutation plots.
Highly correlated genes for IDUA:
Showing top 20/65 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IDUA | OBP2B | 0.745078 | 3 | 0 | 3 |
| IDUA | ZNF517 | 0.638798 | 3 | 0 | 3 |
| IDUA | C19orf81 | 0.635732 | 4 | 0 | 3 |
| IDUA | TREM2 | 0.621509 | 3 | 0 | 3 |
| IDUA | CBFA2T3 | 0.615221 | 5 | 0 | 5 |
| IDUA | TNFRSF14 | 0.613413 | 4 | 0 | 3 |
| IDUA | POU2F2 | 0.609792 | 4 | 0 | 3 |
| IDUA | USHBP1 | 0.607127 | 3 | 0 | 3 |
| IDUA | IQCF2 | 0.602315 | 3 | 0 | 3 |
| IDUA | ADAMTS14 | 0.601125 | 3 | 0 | 3 |
| IDUA | PKLR | 0.594933 | 5 | 0 | 4 |
| IDUA | HTRA3 | 0.594855 | 3 | 0 | 3 |
| IDUA | FAM71E2 | 0.58954 | 3 | 0 | 3 |
| IDUA | ABCA7 | 0.586409 | 5 | 0 | 5 |
| IDUA | MEGF6 | 0.581878 | 4 | 0 | 3 |
| IDUA | PDGFB | 0.573528 | 3 | 0 | 3 |
| IDUA | ZNF324 | 0.57291 | 3 | 0 | 3 |
| IDUA | CDHR5 | 0.571801 | 4 | 0 | 3 |
| IDUA | WFDC8 | 0.568653 | 3 | 0 | 3 |
| IDUA | HMCN2 | 0.566057 | 3 | 0 | 3 |
For details and further investigation, click here
