| Full name: HtrA serine peptidase 3 | Alias Symbol: Tasp|Prsp | ||
| Type: protein-coding gene | Cytoband: 4p16.1 | ||
| Entrez ID: 94031 | HGNC ID: HGNC:30406 | Ensembl Gene: ENSG00000170801 | OMIM ID: 608785 |
| Drug and gene relationship at DGIdb | |||
Expression of HTRA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTRA3 | 94031 | 226944_at | 0.8145 | 0.0868 | |
| GSE26886 | HTRA3 | 94031 | 226944_at | 0.8820 | 0.0000 | |
| GSE45670 | HTRA3 | 94031 | 226944_at | 0.0981 | 0.5438 | |
| GSE53622 | HTRA3 | 94031 | 24686 | 1.7466 | 0.0000 | |
| GSE53624 | HTRA3 | 94031 | 24686 | 0.6903 | 0.0000 | |
| GSE63941 | HTRA3 | 94031 | 226944_at | -0.6348 | 0.0449 | |
| GSE77861 | HTRA3 | 94031 | 226944_at | 0.0403 | 0.8141 | |
| GSE97050 | HTRA3 | 94031 | A_33_P3270776 | 0.9572 | 0.1403 | |
| SRP007169 | HTRA3 | 94031 | RNAseq | 8.0442 | 0.0000 | |
| SRP008496 | HTRA3 | 94031 | RNAseq | 7.5072 | 0.0000 | |
| SRP064894 | HTRA3 | 94031 | RNAseq | 1.9303 | 0.0000 | |
| SRP133303 | HTRA3 | 94031 | RNAseq | 2.7337 | 0.0000 | |
| SRP159526 | HTRA3 | 94031 | RNAseq | 1.5872 | 0.0010 | |
| SRP193095 | HTRA3 | 94031 | RNAseq | 3.4614 | 0.0000 | |
| SRP219564 | HTRA3 | 94031 | RNAseq | 2.6274 | 0.0116 | |
| TCGA | HTRA3 | 94031 | RNAseq | 0.2892 | 0.0282 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by HTRA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTRA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTRA3 | 94031 | 0 | 18 | 12 | |
| GSE20123 | HTRA3 | 94031 | 0 | 18 | 12 | |
| GSE43470 | HTRA3 | 94031 | 0 | 17 | 26 | |
| GSE46452 | HTRA3 | 94031 | 1 | 36 | 22 | |
| GSE47630 | HTRA3 | 94031 | 1 | 19 | 20 | |
| GSE54993 | HTRA3 | 94031 | 10 | 0 | 60 | |
| GSE54994 | HTRA3 | 94031 | 3 | 12 | 38 | |
| GSE60625 | HTRA3 | 94031 | 0 | 0 | 11 | |
| GSE74703 | HTRA3 | 94031 | 0 | 13 | 23 | |
| GSE74704 | HTRA3 | 94031 | 0 | 10 | 10 | |
| TCGA | HTRA3 | 94031 | 8 | 47 | 41 |
Total number of gains: 23; Total number of losses: 190; Total Number of normals: 275.
Somatic mutations of HTRA3:
Generating mutation plots.
Highly correlated genes for HTRA3:
Showing top 20/630 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTRA3 | ICE1 | 0.730039 | 3 | 0 | 3 |
| HTRA3 | SULF1 | 0.726068 | 7 | 0 | 7 |
| HTRA3 | CMC2 | 0.720365 | 3 | 0 | 3 |
| HTRA3 | ADAMTS12 | 0.71072 | 6 | 0 | 6 |
| HTRA3 | VCAN | 0.70062 | 8 | 0 | 7 |
| HTRA3 | FRS3 | 0.698788 | 3 | 0 | 3 |
| HTRA3 | DUSP9 | 0.690103 | 3 | 0 | 3 |
| HTRA3 | PLAUR | 0.689275 | 6 | 0 | 5 |
| HTRA3 | CALU | 0.686091 | 6 | 0 | 5 |
| HTRA3 | HTRA1 | 0.68338 | 8 | 0 | 7 |
| HTRA3 | COL5A1 | 0.678924 | 8 | 0 | 8 |
| HTRA3 | SLC16A10 | 0.678087 | 4 | 0 | 4 |
| HTRA3 | ZNF697 | 0.678063 | 3 | 0 | 3 |
| HTRA3 | POSTN | 0.676126 | 8 | 0 | 6 |
| HTRA3 | MXRA8 | 0.675424 | 9 | 0 | 7 |
| HTRA3 | LOXL2 | 0.674035 | 7 | 0 | 6 |
| HTRA3 | GRAMD1A | 0.67298 | 5 | 0 | 4 |
| HTRA3 | SPARC | 0.67123 | 8 | 0 | 6 |
| HTRA3 | NOX4 | 0.67075 | 7 | 0 | 5 |
| HTRA3 | LRP3 | 0.669579 | 4 | 0 | 3 |
For details and further investigation, click here
