| Full name: triggering receptor expressed on myeloid cells 2 | Alias Symbol: TREM-2|Trem2a|Trem2b|Trem2c | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 54209 | HGNC ID: HGNC:17761 | Ensembl Gene: ENSG00000095970 | OMIM ID: 605086 |
| Drug and gene relationship at DGIdb | |||
TREM2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation |
Expression of TREM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TREM2 | 54209 | 219725_at | 0.8032 | 0.0945 | |
| GSE20347 | TREM2 | 54209 | 219725_at | 0.4309 | 0.0003 | |
| GSE23400 | TREM2 | 54209 | 219725_at | 0.2926 | 0.0003 | |
| GSE26886 | TREM2 | 54209 | 219725_at | 0.3097 | 0.0609 | |
| GSE29001 | TREM2 | 54209 | 219725_at | 0.2646 | 0.0483 | |
| GSE38129 | TREM2 | 54209 | 219725_at | 0.6576 | 0.0000 | |
| GSE45670 | TREM2 | 54209 | 219725_at | 0.7294 | 0.0064 | |
| GSE53622 | TREM2 | 54209 | 16846 | 3.1737 | 0.0000 | |
| GSE53624 | TREM2 | 54209 | 16846 | 3.0388 | 0.0000 | |
| GSE63941 | TREM2 | 54209 | 219725_at | 0.1636 | 0.6349 | |
| GSE77861 | TREM2 | 54209 | 219725_at | 0.0527 | 0.7008 | |
| GSE97050 | TREM2 | 54209 | A_24_P12397 | 1.0658 | 0.0832 | |
| SRP007169 | TREM2 | 54209 | RNAseq | 5.1278 | 0.0000 | |
| SRP064894 | TREM2 | 54209 | RNAseq | 3.9680 | 0.0000 | |
| SRP133303 | TREM2 | 54209 | RNAseq | 3.6111 | 0.0000 | |
| SRP159526 | TREM2 | 54209 | RNAseq | 3.4400 | 0.0000 | |
| SRP219564 | TREM2 | 54209 | RNAseq | 4.2322 | 0.0000 | |
| TCGA | TREM2 | 54209 | RNAseq | 1.7364 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by TREM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TREM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TREM2 | 54209 | 3 | 3 | 24 | |
| GSE20123 | TREM2 | 54209 | 3 | 3 | 24 | |
| GSE43470 | TREM2 | 54209 | 6 | 0 | 37 | |
| GSE46452 | TREM2 | 54209 | 2 | 9 | 48 | |
| GSE47630 | TREM2 | 54209 | 8 | 4 | 28 | |
| GSE54993 | TREM2 | 54209 | 3 | 2 | 65 | |
| GSE54994 | TREM2 | 54209 | 11 | 4 | 38 | |
| GSE60625 | TREM2 | 54209 | 0 | 1 | 10 | |
| GSE74703 | TREM2 | 54209 | 6 | 0 | 30 | |
| GSE74704 | TREM2 | 54209 | 1 | 3 | 16 | |
| TCGA | TREM2 | 54209 | 19 | 13 | 64 |
Total number of gains: 62; Total number of losses: 42; Total Number of normals: 384.
Somatic mutations of TREM2:
Generating mutation plots.
Highly correlated genes for TREM2:
Showing top 20/1614 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TREM2 | PDIA5 | 0.796774 | 3 | 0 | 3 |
| TREM2 | SUCNR1 | 0.783807 | 3 | 0 | 3 |
| TREM2 | PYCR2 | 0.771278 | 3 | 0 | 3 |
| TREM2 | FCGR3A | 0.757351 | 3 | 0 | 3 |
| TREM2 | SPON2 | 0.753175 | 3 | 0 | 3 |
| TREM2 | FAM89A | 0.748686 | 3 | 0 | 3 |
| TREM2 | LRRC8C | 0.742411 | 3 | 0 | 3 |
| TREM2 | ANLN | 0.741396 | 5 | 0 | 5 |
| TREM2 | DNAJB11 | 0.73604 | 5 | 0 | 4 |
| TREM2 | USP41 | 0.730416 | 3 | 0 | 3 |
| TREM2 | INO80B | 0.729166 | 4 | 0 | 4 |
| TREM2 | SNAP47 | 0.72098 | 3 | 0 | 3 |
| TREM2 | SLC35B2 | 0.717609 | 3 | 0 | 3 |
| TREM2 | WDR53 | 0.714485 | 4 | 0 | 4 |
| TREM2 | DLX2 | 0.711905 | 3 | 0 | 3 |
| TREM2 | CLSPN | 0.711269 | 6 | 0 | 6 |
| TREM2 | FMNL2 | 0.710318 | 6 | 0 | 5 |
| TREM2 | CTHRC1 | 0.710257 | 6 | 0 | 6 |
| TREM2 | PIK3AP1 | 0.709992 | 3 | 0 | 3 |
| TREM2 | IMP4 | 0.709035 | 5 | 0 | 4 |
For details and further investigation, click here
