| Full name: interferon induced with helicase C domain 1 | Alias Symbol: MDA-5|Hlcd|MDA5|IDDM19 | ||
| Type: protein-coding gene | Cytoband: 2q24.2 | ||
| Entrez ID: 64135 | HGNC ID: HGNC:18873 | Ensembl Gene: ENSG00000115267 | OMIM ID: 606951 |
| Drug and gene relationship at DGIdb | |||
IFIH1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04622 | RIG-I-like receptor signaling pathway | |
| hsa05161 | Hepatitis B | |
| hsa05162 | Measles | |
| hsa05164 | Influenza A | |
| hsa05168 | Herpes simplex infection |
Expression of IFIH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IFIH1 | 64135 | 219209_at | 0.7548 | 0.3988 | |
| GSE20347 | IFIH1 | 64135 | 219209_at | 0.3739 | 0.2803 | |
| GSE23400 | IFIH1 | 64135 | 219209_at | 0.4770 | 0.0008 | |
| GSE26886 | IFIH1 | 64135 | 219209_at | 0.2231 | 0.5690 | |
| GSE29001 | IFIH1 | 64135 | 219209_at | 1.1363 | 0.0060 | |
| GSE38129 | IFIH1 | 64135 | 219209_at | 0.3515 | 0.1671 | |
| GSE45670 | IFIH1 | 64135 | 219209_at | 1.1790 | 0.0031 | |
| GSE63941 | IFIH1 | 64135 | 219209_at | -0.2343 | 0.8692 | |
| GSE77861 | IFIH1 | 64135 | 219209_at | -0.1967 | 0.6840 | |
| GSE97050 | IFIH1 | 64135 | A_23_P68155 | 0.7247 | 0.1890 | |
| SRP007169 | IFIH1 | 64135 | RNAseq | 2.4269 | 0.0001 | |
| SRP008496 | IFIH1 | 64135 | RNAseq | 1.6426 | 0.0003 | |
| SRP064894 | IFIH1 | 64135 | RNAseq | 1.2718 | 0.0000 | |
| SRP133303 | IFIH1 | 64135 | RNAseq | 0.7615 | 0.0089 | |
| SRP159526 | IFIH1 | 64135 | RNAseq | -0.6321 | 0.1847 | |
| SRP193095 | IFIH1 | 64135 | RNAseq | 0.5736 | 0.0004 | |
| SRP219564 | IFIH1 | 64135 | RNAseq | 0.4645 | 0.5139 | |
| TCGA | IFIH1 | 64135 | RNAseq | 0.2402 | 0.0203 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by IFIH1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of IFIH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IFIH1 | 64135 | 4 | 1 | 25 | |
| GSE20123 | IFIH1 | 64135 | 4 | 1 | 25 | |
| GSE43470 | IFIH1 | 64135 | 4 | 1 | 38 | |
| GSE46452 | IFIH1 | 64135 | 1 | 4 | 54 | |
| GSE47630 | IFIH1 | 64135 | 5 | 3 | 32 | |
| GSE54993 | IFIH1 | 64135 | 0 | 5 | 65 | |
| GSE54994 | IFIH1 | 64135 | 11 | 2 | 40 | |
| GSE60625 | IFIH1 | 64135 | 0 | 3 | 8 | |
| GSE74703 | IFIH1 | 64135 | 3 | 1 | 32 | |
| GSE74704 | IFIH1 | 64135 | 3 | 0 | 17 | |
| TCGA | IFIH1 | 64135 | 23 | 10 | 63 |
Total number of gains: 58; Total number of losses: 31; Total Number of normals: 399.
Somatic mutations of IFIH1:
Generating mutation plots.
Highly correlated genes for IFIH1:
Showing top 20/425 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IFIH1 | EPSTI1 | 0.819537 | 5 | 0 | 5 |
| IFIH1 | RBM12B | 0.784486 | 3 | 0 | 3 |
| IFIH1 | IFI44 | 0.784274 | 11 | 0 | 11 |
| IFIH1 | NMI | 0.779717 | 11 | 0 | 11 |
| IFIH1 | DDX60 | 0.774653 | 11 | 0 | 11 |
| IFIH1 | PARP9 | 0.764654 | 7 | 0 | 7 |
| IFIH1 | MTRR | 0.759348 | 3 | 0 | 3 |
| IFIH1 | WDYHV1 | 0.750743 | 3 | 0 | 3 |
| IFIH1 | STAT1 | 0.749477 | 11 | 0 | 9 |
| IFIH1 | METTL14 | 0.742472 | 3 | 0 | 3 |
| IFIH1 | CD80 | 0.735081 | 3 | 0 | 3 |
| IFIH1 | DDX60L | 0.733963 | 7 | 0 | 6 |
| IFIH1 | IFIT1 | 0.733684 | 11 | 0 | 10 |
| IFIH1 | SLC25A32 | 0.732318 | 3 | 0 | 3 |
| IFIH1 | GBP1 | 0.727898 | 10 | 0 | 9 |
| IFIH1 | TATDN1 | 0.726144 | 3 | 0 | 3 |
| IFIH1 | TAP1 | 0.726078 | 11 | 0 | 10 |
| IFIH1 | IFI44L | 0.716593 | 11 | 0 | 10 |
| IFIH1 | RSAD2 | 0.715923 | 11 | 0 | 9 |
| IFIH1 | MX1 | 0.712204 | 10 | 0 | 9 |
For details and further investigation, click here
