STAT1

 

Full name: signal transducer and activator of transcription 1 Alias Symbol: STAT91|ISGF-3
Type: protein-coding gene Cytoband: 2q32.2
Entrez ID: 6772 HGNC ID: HGNC:11362 Ensembl Gene: ENSG00000115415 OMIM ID: 600555
Drug and gene relationship at DGIdb

 

STAT1 involved pathways:

KEGG pathway Description View
hsa04062Chemokine signaling pathway
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05321Inflammatory bowel disease (IBD)

 

Expression of STAT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 STAT1 6772 200887_s_at 0.6247 0.4179
GSE20347 STAT1 6772 200887_s_at 0.6692 0.0267
GSE23400 STAT1 6772 200887_s_at 1.0121 0.0000
GSE26886 STAT1 6772 200887_s_at 0.5629 0.0754
GSE29001 STAT1 6772 200887_s_at 0.8956 0.0350
GSE38129 STAT1 6772 200887_s_at 0.7198 0.0008
GSE45670 STAT1 6772 200887_s_at 1.2629 0.0002
GSE53622 STAT1 6772 45544 1.6062 0.0000
GSE53624 STAT1 6772 45544 1.7456 0.0000
GSE63941 STAT1 6772 200887_s_at -2.2553 0.0007
GSE77861 STAT1 6772 200887_s_at 0.4006 0.1837
GSE97050 STAT1 6772 A_24_P274270 1.5916 0.0782
SRP007169 STAT1 6772 RNAseq 1.6899 0.0063
SRP008496 STAT1 6772 RNAseq 1.1018 0.0112
SRP064894 STAT1 6772 RNAseq 1.8903 0.0000
SRP133303 STAT1 6772 RNAseq 1.0670 0.0020
SRP159526 STAT1 6772 RNAseq 0.6094 0.3227
SRP193095 STAT1 6772 RNAseq 1.1571 0.0000
SRP219564 STAT1 6772 RNAseq 1.8539 0.0122
TCGA STAT1 6772 RNAseq 0.3731 0.0000

Upregulated datasets: 10; Downregulated datasets: 1.  

 

Survival by STAT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of STAT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 STAT1 6772 8 2 20
GSE20123 STAT1 6772 8 2 20
GSE43470 STAT1 6772 3 1 39
GSE46452 STAT1 6772 1 4 54
GSE47630 STAT1 6772 4 5 31
GSE54993 STAT1 6772 0 5 65
GSE54994 STAT1 6772 12 6 35
GSE60625 STAT1 6772 0 3 8
GSE74703 STAT1 6772 2 1 33
GSE74704 STAT1 6772 3 2 15
TCGA STAT1 6772 24 8 64

Total number of gains: 65; Total number of losses: 39; Total Number of normals: 384.  

 

Somatic mutations of STAT1:

 

Generating mutation plots.

 

Highly correlated genes for STAT1:

 

Showing top 20/763 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
STAT1USP410.847707303
STAT1GBP10.78651412012
STAT1DDX60L0.785708706
STAT1PARP140.784421808
STAT1DDX600.77437313013
STAT1PSME20.768402404
STAT1IFI60.76499113013
STAT1EPSTI10.764941908
STAT1TAP10.76376611011
STAT1CMPK20.756103807
STAT1IFIH10.7494771109
STAT1UBE2L60.74899112011
STAT1SP1100.74812312011
STAT1XAF10.7426913013
STAT1IFI440.74004313012
STAT1RSAD20.73764512011
STAT1OAS30.72766112012
STAT1PARP90.726589808
STAT1ISG150.72619713013
STAT1NMI0.72579811010

For details and further investigation, click here