IKBKB

 

Full name: inhibitor of nuclear factor kappa B kinase subunit beta Alias Symbol: IKK2|NFKBIKB|IKK-beta|IKKB
Type: protein-coding gene Cytoband: 8p11.21
Entrez ID: 3551 HGNC ID: HGNC:5960 Ensembl Gene: ENSG00000104365 OMIM ID: 603258
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

IKBKB involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04068FoxO signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04210Apoptosis
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04668TNF signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05215Prostate cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer

 

Expression of IKBKB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IKBKB 3551 209341_s_at -0.2725 0.5583
GSE20347 IKBKB 3551 209341_s_at -0.1989 0.4077
GSE23400 IKBKB 3551 209341_s_at 0.1800 0.1357
GSE26886 IKBKB 3551 209341_s_at -0.7175 0.0176
GSE29001 IKBKB 3551 209341_s_at 0.0864 0.7976
GSE38129 IKBKB 3551 209341_s_at -0.2771 0.0700
GSE45670 IKBKB 3551 209341_s_at -0.0671 0.7089
GSE53622 IKBKB 3551 69712 -0.2353 0.0006
GSE53624 IKBKB 3551 69712 -0.2874 0.0000
GSE63941 IKBKB 3551 209341_s_at -1.7851 0.0008
GSE77861 IKBKB 3551 209341_s_at 0.0613 0.9202
GSE97050 IKBKB 3551 A_33_P3787904 0.2582 0.2337
SRP007169 IKBKB 3551 RNAseq 0.5927 0.1706
SRP008496 IKBKB 3551 RNAseq 0.0218 0.9373
SRP064894 IKBKB 3551 RNAseq 0.0703 0.6983
SRP133303 IKBKB 3551 RNAseq -0.2682 0.1932
SRP159526 IKBKB 3551 RNAseq -0.5089 0.0510
SRP193095 IKBKB 3551 RNAseq 0.0500 0.7152
SRP219564 IKBKB 3551 RNAseq -0.2923 0.3613
TCGA IKBKB 3551 RNAseq 0.0275 0.6869

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by IKBKB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IKBKB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IKBKB 3551 10 5 15
GSE20123 IKBKB 3551 10 5 15
GSE43470 IKBKB 3551 9 6 28
GSE46452 IKBKB 3551 19 5 35
GSE47630 IKBKB 3551 22 1 17
GSE54993 IKBKB 3551 1 16 53
GSE54994 IKBKB 3551 19 7 27
GSE60625 IKBKB 3551 3 0 8
GSE74703 IKBKB 3551 8 5 23
GSE74704 IKBKB 3551 9 2 9
TCGA IKBKB 3551 41 22 33

Total number of gains: 151; Total number of losses: 74; Total Number of normals: 263.  

 

Somatic mutations of IKBKB:

 

Generating mutation plots.

 

Highly correlated genes for IKBKB:

 

Showing top 20/54 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IKBKBZNF7110.718418303
IKBKBWNT5B0.718409303
IKBKBHINFP0.677515303
IKBKBMBP0.654177303
IKBKBIRGQ0.642693403
IKBKBKAT6A0.641205807
IKBKBZNF6770.63709303
IKBKBPIWIL40.624216303
IKBKBUSP460.615322303
IKBKBTBC1D90.614392605
IKBKBZFPM20.614284303
IKBKBCARD80.613792403
IKBKBERLIN20.608767504
IKBKBZNF6820.600172504
IKBKBGRIPAP10.598592303
IKBKBCXorf380.595158403
IKBKBTP53INP10.593142504
IKBKBFAM171A10.587868404
IKBKBOARD10.586822403
IKBKBGALNT50.586181303

For details and further investigation, click here