| Full name: caspase recruitment domain family member 8 | Alias Symbol: TUCAN|KIAA0955|CARDINAL|NDPP|Dakar | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 22900 | HGNC ID: HGNC:17057 | Ensembl Gene: ENSG00000105483 | OMIM ID: 609051 |
| Drug and gene relationship at DGIdb | |||
CARD8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04621 | NOD-like receptor signaling pathway |
Expression of CARD8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CARD8 | 22900 | 1554479_a_at | 0.2778 | 0.7910 | |
| GSE20347 | CARD8 | 22900 | 204950_at | 0.0750 | 0.5248 | |
| GSE23400 | CARD8 | 22900 | 204950_at | 0.0405 | 0.2896 | |
| GSE26886 | CARD8 | 22900 | 1554479_a_at | -0.5679 | 0.1000 | |
| GSE29001 | CARD8 | 22900 | 204950_at | 0.1048 | 0.6299 | |
| GSE38129 | CARD8 | 22900 | 204950_at | -0.0791 | 0.6244 | |
| GSE45670 | CARD8 | 22900 | 1554479_a_at | -0.1851 | 0.6318 | |
| GSE53622 | CARD8 | 22900 | 59577 | -0.3668 | 0.0000 | |
| GSE53624 | CARD8 | 22900 | 4530 | 0.4111 | 0.0000 | |
| GSE63941 | CARD8 | 22900 | 1554479_a_at | -1.6887 | 0.0179 | |
| GSE77861 | CARD8 | 22900 | 204950_at | 0.0989 | 0.4573 | |
| GSE97050 | CARD8 | 22900 | A_24_P14260 | 0.2353 | 0.3624 | |
| SRP007169 | CARD8 | 22900 | RNAseq | 0.2371 | 0.7670 | |
| SRP008496 | CARD8 | 22900 | RNAseq | -0.2508 | 0.5649 | |
| SRP064894 | CARD8 | 22900 | RNAseq | 0.5906 | 0.0003 | |
| SRP133303 | CARD8 | 22900 | RNAseq | 0.0017 | 0.9907 | |
| SRP159526 | CARD8 | 22900 | RNAseq | -0.1475 | 0.5729 | |
| SRP193095 | CARD8 | 22900 | RNAseq | 0.1912 | 0.2360 | |
| SRP219564 | CARD8 | 22900 | RNAseq | 0.1311 | 0.4819 | |
| TCGA | CARD8 | 22900 | RNAseq | -0.2935 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CARD8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CARD8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CARD8 | 22900 | 4 | 4 | 22 | |
| GSE20123 | CARD8 | 22900 | 4 | 3 | 23 | |
| GSE43470 | CARD8 | 22900 | 3 | 11 | 29 | |
| GSE46452 | CARD8 | 22900 | 45 | 1 | 13 | |
| GSE47630 | CARD8 | 22900 | 9 | 6 | 25 | |
| GSE54993 | CARD8 | 22900 | 17 | 4 | 49 | |
| GSE54994 | CARD8 | 22900 | 4 | 14 | 35 | |
| GSE60625 | CARD8 | 22900 | 9 | 0 | 2 | |
| GSE74703 | CARD8 | 22900 | 3 | 7 | 26 | |
| GSE74704 | CARD8 | 22900 | 4 | 1 | 15 | |
| TCGA | CARD8 | 22900 | 15 | 19 | 62 |
Total number of gains: 117; Total number of losses: 70; Total Number of normals: 301.
Somatic mutations of CARD8:
Generating mutation plots.
Highly correlated genes for CARD8:
Showing top 20/77 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CARD8 | LYG1 | 0.741529 | 3 | 0 | 3 |
| CARD8 | SFMBT2 | 0.734902 | 3 | 0 | 3 |
| CARD8 | ARHGAP21 | 0.704421 | 3 | 0 | 3 |
| CARD8 | CCDC89 | 0.695264 | 3 | 0 | 3 |
| CARD8 | MANEAL | 0.678277 | 3 | 0 | 3 |
| CARD8 | CHGB | 0.669621 | 3 | 0 | 3 |
| CARD8 | APBA2 | 0.65848 | 3 | 0 | 3 |
| CARD8 | PPM1F | 0.643037 | 5 | 0 | 3 |
| CARD8 | CD8B | 0.641671 | 4 | 0 | 3 |
| CARD8 | HPS1 | 0.639801 | 4 | 0 | 3 |
| CARD8 | CD7 | 0.638418 | 4 | 0 | 3 |
| CARD8 | PRKCB | 0.635051 | 7 | 0 | 6 |
| CARD8 | ADRA2A | 0.623778 | 4 | 0 | 3 |
| CARD8 | TBC1D10C | 0.619642 | 5 | 0 | 3 |
| CARD8 | SCN3A | 0.617464 | 5 | 0 | 3 |
| CARD8 | IKBKB | 0.613792 | 4 | 0 | 3 |
| CARD8 | AKNA | 0.612948 | 6 | 0 | 4 |
| CARD8 | GIT2 | 0.607147 | 6 | 0 | 3 |
| CARD8 | MAST3 | 0.602459 | 6 | 0 | 5 |
| CARD8 | TCEAL7 | 0.594988 | 4 | 0 | 3 |
For details and further investigation, click here
