| Full name: myelin basic protein | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18q23 | ||
| Entrez ID: 4155 | HGNC ID: HGNC:6925 | Ensembl Gene: ENSG00000197971 | OMIM ID: 159430 |
| Drug and gene relationship at DGIdb | |||
Expression of MBP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MBP | 4155 | 210136_at | -0.2074 | 0.6839 | |
| GSE20347 | MBP | 4155 | 210136_at | -0.4907 | 0.0597 | |
| GSE23400 | MBP | 4155 | 210136_at | -0.3965 | 0.0260 | |
| GSE26886 | MBP | 4155 | 210136_at | -1.4395 | 0.0002 | |
| GSE29001 | MBP | 4155 | 210136_at | -0.4912 | 0.2552 | |
| GSE38129 | MBP | 4155 | 210136_at | -0.3433 | 0.1048 | |
| GSE45670 | MBP | 4155 | 210136_at | -0.6837 | 0.0031 | |
| GSE53622 | MBP | 4155 | 104454 | -0.6608 | 0.0000 | |
| GSE53624 | MBP | 4155 | 104454 | -0.7383 | 0.0000 | |
| GSE63941 | MBP | 4155 | 210136_at | 0.5412 | 0.6176 | |
| GSE77861 | MBP | 4155 | 225407_at | -0.1540 | 0.4792 | |
| GSE97050 | MBP | 4155 | A_33_P3227990 | -0.7225 | 0.1560 | |
| SRP007169 | MBP | 4155 | RNAseq | -1.7883 | 0.0000 | |
| SRP008496 | MBP | 4155 | RNAseq | -1.4683 | 0.0001 | |
| SRP064894 | MBP | 4155 | RNAseq | -0.6495 | 0.0296 | |
| SRP133303 | MBP | 4155 | RNAseq | -0.7009 | 0.0001 | |
| SRP159526 | MBP | 4155 | RNAseq | -0.9121 | 0.0313 | |
| SRP193095 | MBP | 4155 | RNAseq | -0.6711 | 0.0000 | |
| SRP219564 | MBP | 4155 | RNAseq | -1.2549 | 0.0006 | |
| TCGA | MBP | 4155 | RNAseq | -0.1377 | 0.0139 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by MBP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MBP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MBP | 4155 | 0 | 11 | 19 | |
| GSE20123 | MBP | 4155 | 0 | 11 | 19 | |
| GSE43470 | MBP | 4155 | 0 | 10 | 33 | |
| GSE46452 | MBP | 4155 | 1 | 26 | 32 | |
| GSE47630 | MBP | 4155 | 5 | 22 | 13 | |
| GSE54993 | MBP | 4155 | 9 | 0 | 61 | |
| GSE54994 | MBP | 4155 | 1 | 18 | 34 | |
| GSE60625 | MBP | 4155 | 0 | 4 | 7 | |
| GSE74703 | MBP | 4155 | 0 | 8 | 28 | |
| GSE74704 | MBP | 4155 | 0 | 9 | 11 | |
| TCGA | MBP | 4155 | 7 | 47 | 42 |
Total number of gains: 23; Total number of losses: 166; Total Number of normals: 299.
Somatic mutations of MBP:
Generating mutation plots.
Highly correlated genes for MBP:
Showing top 20/71 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MBP | UQCRC1 | 0.681331 | 3 | 0 | 3 |
| MBP | C14orf28 | 0.666978 | 3 | 0 | 3 |
| MBP | IKBKB | 0.654177 | 3 | 0 | 3 |
| MBP | UBN2 | 0.648951 | 3 | 0 | 3 |
| MBP | C6orf132 | 0.636497 | 4 | 0 | 3 |
| MBP | RTCA | 0.635539 | 3 | 0 | 3 |
| MBP | SYCP3 | 0.627804 | 3 | 0 | 3 |
| MBP | RPL6 | 0.622181 | 3 | 0 | 3 |
| MBP | RXRB | 0.619429 | 3 | 0 | 3 |
| MBP | C11orf65 | 0.616079 | 3 | 0 | 3 |
| MBP | PCBD1 | 0.608897 | 3 | 0 | 3 |
| MBP | GIGYF2 | 0.603379 | 4 | 0 | 3 |
| MBP | BRAF | 0.592815 | 3 | 0 | 3 |
| MBP | SYNJ2 | 0.58928 | 4 | 0 | 3 |
| MBP | ZC3H6 | 0.581961 | 4 | 0 | 3 |
| MBP | TDRD7 | 0.577783 | 5 | 0 | 4 |
| MBP | AKTIP | 0.574465 | 5 | 0 | 3 |
| MBP | BUD13 | 0.568925 | 5 | 0 | 3 |
| MBP | C15orf41 | 0.568487 | 3 | 0 | 3 |
| MBP | PDZD2 | 0.560812 | 5 | 0 | 3 |
For details and further investigation, click here
