| Full name: IKAROS family zinc finger 1 | Alias Symbol: hIk-1|LyF-1|Hs.54452|IKAROS|PPP1R92 | ||
| Type: protein-coding gene | Cytoband: 7p12.2 | ||
| Entrez ID: 10320 | HGNC ID: HGNC:13176 | Ensembl Gene: ENSG00000185811 | OMIM ID: 603023 |
| Drug and gene relationship at DGIdb | |||
Expression of IKZF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IKZF1 | 10320 | 205039_s_at | -0.0272 | 0.9714 | |
| GSE20347 | IKZF1 | 10320 | 205039_s_at | -0.1543 | 0.2171 | |
| GSE23400 | IKZF1 | 10320 | 205039_s_at | -0.0801 | 0.0126 | |
| GSE26886 | IKZF1 | 10320 | 205039_s_at | -0.2704 | 0.1852 | |
| GSE29001 | IKZF1 | 10320 | 205039_s_at | 0.0722 | 0.7237 | |
| GSE38129 | IKZF1 | 10320 | 205039_s_at | -0.2331 | 0.0678 | |
| GSE45670 | IKZF1 | 10320 | 205039_s_at | -0.2910 | 0.0852 | |
| GSE53622 | IKZF1 | 10320 | 20593 | -0.3490 | 0.0286 | |
| GSE53624 | IKZF1 | 10320 | 20593 | -0.4710 | 0.0004 | |
| GSE63941 | IKZF1 | 10320 | 205039_s_at | 0.3745 | 0.0583 | |
| GSE77861 | IKZF1 | 10320 | 205039_s_at | 0.0522 | 0.6467 | |
| GSE97050 | IKZF1 | 10320 | A_33_P3842556 | 0.8888 | 0.1681 | |
| SRP007169 | IKZF1 | 10320 | RNAseq | -0.2056 | 0.7536 | |
| SRP008496 | IKZF1 | 10320 | RNAseq | -0.7126 | 0.1254 | |
| SRP064894 | IKZF1 | 10320 | RNAseq | 0.0259 | 0.9213 | |
| SRP133303 | IKZF1 | 10320 | RNAseq | -0.6198 | 0.0118 | |
| SRP159526 | IKZF1 | 10320 | RNAseq | -0.9595 | 0.2364 | |
| SRP193095 | IKZF1 | 10320 | RNAseq | -0.2822 | 0.2902 | |
| SRP219564 | IKZF1 | 10320 | RNAseq | -0.0726 | 0.9025 | |
| TCGA | IKZF1 | 10320 | RNAseq | -0.1001 | 0.5213 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IKZF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IKZF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IKZF1 | 10320 | 12 | 0 | 18 | |
| GSE20123 | IKZF1 | 10320 | 11 | 0 | 19 | |
| GSE43470 | IKZF1 | 10320 | 4 | 1 | 38 | |
| GSE46452 | IKZF1 | 10320 | 11 | 1 | 47 | |
| GSE47630 | IKZF1 | 10320 | 8 | 1 | 31 | |
| GSE54993 | IKZF1 | 10320 | 0 | 8 | 62 | |
| GSE54994 | IKZF1 | 10320 | 18 | 2 | 33 | |
| GSE60625 | IKZF1 | 10320 | 0 | 0 | 11 | |
| GSE74703 | IKZF1 | 10320 | 4 | 1 | 31 | |
| GSE74704 | IKZF1 | 10320 | 5 | 0 | 15 | |
| TCGA | IKZF1 | 10320 | 48 | 10 | 38 |
Total number of gains: 121; Total number of losses: 24; Total Number of normals: 343.
Somatic mutations of IKZF1:
Generating mutation plots.
Highly correlated genes for IKZF1:
Showing top 20/350 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IKZF1 | GPR174 | 0.817166 | 3 | 0 | 3 |
| IKZF1 | C16orf54 | 0.795014 | 5 | 0 | 5 |
| IKZF1 | PREX1 | 0.761699 | 4 | 0 | 4 |
| IKZF1 | C1orf162 | 0.755804 | 6 | 0 | 5 |
| IKZF1 | SNX20 | 0.755208 | 6 | 0 | 5 |
| IKZF1 | SUSD3 | 0.754047 | 5 | 0 | 5 |
| IKZF1 | TIFAB | 0.742964 | 3 | 0 | 3 |
| IKZF1 | GIMAP1 | 0.736493 | 6 | 0 | 6 |
| IKZF1 | TNFAIP8L2 | 0.7317 | 7 | 0 | 6 |
| IKZF1 | CORO1A | 0.729153 | 9 | 0 | 7 |
| IKZF1 | BIN2 | 0.727568 | 8 | 0 | 6 |
| IKZF1 | CR1L | 0.720145 | 4 | 0 | 4 |
| IKZF1 | TAGAP | 0.718476 | 6 | 0 | 5 |
| IKZF1 | HLA-DOA | 0.718294 | 6 | 0 | 4 |
| IKZF1 | RAB39B | 0.715274 | 4 | 0 | 4 |
| IKZF1 | IRF8 | 0.714219 | 9 | 0 | 7 |
| IKZF1 | CLEC17A | 0.713043 | 3 | 0 | 3 |
| IKZF1 | KLRB1 | 0.70616 | 8 | 0 | 7 |
| IKZF1 | TBC1D10C | 0.704199 | 5 | 0 | 5 |
| IKZF1 | LILRB1 | 0.703942 | 5 | 0 | 4 |
For details and further investigation, click here
