| Full name: interleukin 12A | Alias Symbol: CLMF|IL-12A|p35|NFSK | ||
| Type: protein-coding gene | Cytoband: 3q25.33 | ||
| Entrez ID: 3592 | HGNC ID: HGNC:5969 | Ensembl Gene: ENSG00000168811 | OMIM ID: 161560 |
| Drug and gene relationship at DGIdb | |||
IL12A involved pathways:
Expression of IL12A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL12A | 3592 | 207160_at | -0.9314 | 0.1061 | |
| GSE20347 | IL12A | 3592 | 207160_at | -0.6084 | 0.0000 | |
| GSE23400 | IL12A | 3592 | 207160_at | -0.3392 | 0.0000 | |
| GSE26886 | IL12A | 3592 | 207160_at | -1.4465 | 0.0000 | |
| GSE29001 | IL12A | 3592 | 207160_at | -1.0558 | 0.0003 | |
| GSE38129 | IL12A | 3592 | 207160_at | -0.6851 | 0.0000 | |
| GSE45670 | IL12A | 3592 | 207160_at | -1.3204 | 0.0001 | |
| GSE53622 | IL12A | 3592 | 64493 | -3.0190 | 0.0000 | |
| GSE53624 | IL12A | 3592 | 64493 | -3.6994 | 0.0000 | |
| GSE63941 | IL12A | 3592 | 207160_at | -1.1153 | 0.0788 | |
| GSE77861 | IL12A | 3592 | 207160_at | -0.3708 | 0.0018 | |
| SRP007169 | IL12A | 3592 | RNAseq | -6.0684 | 0.0000 | |
| SRP064894 | IL12A | 3592 | RNAseq | -3.2222 | 0.0000 | |
| SRP133303 | IL12A | 3592 | RNAseq | -3.0425 | 0.0000 | |
| SRP159526 | IL12A | 3592 | RNAseq | -1.6082 | 0.0012 | |
| SRP219564 | IL12A | 3592 | RNAseq | -3.2834 | 0.0004 | |
| TCGA | IL12A | 3592 | RNAseq | -0.2978 | 0.5114 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by IL12A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL12A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL12A | 3592 | 22 | 0 | 8 | |
| GSE20123 | IL12A | 3592 | 22 | 0 | 8 | |
| GSE43470 | IL12A | 3592 | 23 | 0 | 20 | |
| GSE46452 | IL12A | 3592 | 18 | 2 | 39 | |
| GSE47630 | IL12A | 3592 | 18 | 4 | 18 | |
| GSE54993 | IL12A | 3592 | 1 | 11 | 58 | |
| GSE54994 | IL12A | 3592 | 38 | 1 | 14 | |
| GSE60625 | IL12A | 3592 | 0 | 6 | 5 | |
| GSE74703 | IL12A | 3592 | 20 | 0 | 16 | |
| GSE74704 | IL12A | 3592 | 14 | 0 | 6 | |
| TCGA | IL12A | 3592 | 76 | 1 | 19 |
Total number of gains: 252; Total number of losses: 25; Total Number of normals: 211.
Somatic mutations of IL12A:
Generating mutation plots.
Highly correlated genes for IL12A:
Showing top 20/1336 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL12A | SFTA2 | 0.832556 | 4 | 0 | 4 |
| IL12A | SLC46A2 | 0.825735 | 6 | 0 | 6 |
| IL12A | GYS2 | 0.825191 | 10 | 0 | 10 |
| IL12A | VSIG2 | 0.823762 | 6 | 0 | 6 |
| IL12A | IL12A-AS1 | 0.809726 | 6 | 0 | 6 |
| IL12A | KRT78 | 0.809662 | 6 | 0 | 6 |
| IL12A | SAMD5 | 0.809207 | 6 | 0 | 6 |
| IL12A | PAQR8 | 0.808514 | 6 | 0 | 6 |
| IL12A | GDPD3 | 0.805587 | 10 | 0 | 10 |
| IL12A | UPK1A | 0.804991 | 10 | 0 | 10 |
| IL12A | CRISP3 | 0.8022 | 10 | 0 | 10 |
| IL12A | RANBP9 | 0.79909 | 10 | 0 | 10 |
| IL12A | KLB | 0.796954 | 6 | 0 | 6 |
| IL12A | FCHO2 | 0.795631 | 6 | 0 | 6 |
| IL12A | IQCF1 | 0.795415 | 3 | 0 | 3 |
| IL12A | UBL3 | 0.794978 | 10 | 0 | 10 |
| IL12A | FAM214A | 0.792993 | 6 | 0 | 6 |
| IL12A | SCNN1B | 0.792347 | 10 | 0 | 10 |
| IL12A | ZNRF1 | 0.790546 | 4 | 0 | 4 |
| IL12A | CYSRT1 | 0.789816 | 6 | 0 | 6 |
For details and further investigation, click here
