| Full name: interleukin 17D | Alias Symbol: IL-27|IL-17D|IL27|FLJ30846 | ||
| Type: protein-coding gene | Cytoband: 13q12.11 | ||
| Entrez ID: 53342 | HGNC ID: HGNC:5984 | Ensembl Gene: ENSG00000172458 | OMIM ID: 607587 |
| Drug and gene relationship at DGIdb | |||
IL17D involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of IL17D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL17D | 53342 | 227401_at | -1.2457 | 0.0895 | |
| GSE26886 | IL17D | 53342 | 227401_at | 1.2016 | 0.0031 | |
| GSE45670 | IL17D | 53342 | 227401_at | -1.7871 | 0.0000 | |
| GSE53622 | IL17D | 53342 | 15952 | -0.3813 | 0.0000 | |
| GSE53624 | IL17D | 53342 | 15952 | -0.2168 | 0.0115 | |
| GSE63941 | IL17D | 53342 | 227401_at | -2.5586 | 0.0000 | |
| GSE77861 | IL17D | 53342 | 227401_at | 0.0371 | 0.6553 | |
| GSE97050 | IL17D | 53342 | A_23_P345692 | -0.4812 | 0.3839 | |
| SRP064894 | IL17D | 53342 | RNAseq | -0.6915 | 0.0393 | |
| SRP133303 | IL17D | 53342 | RNAseq | -0.6524 | 0.0504 | |
| SRP159526 | IL17D | 53342 | RNAseq | -0.7034 | 0.0661 | |
| SRP219564 | IL17D | 53342 | RNAseq | -0.7346 | 0.3011 | |
| TCGA | IL17D | 53342 | RNAseq | -0.4494 | 0.0500 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by IL17D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL17D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL17D | 53342 | 1 | 15 | 14 | |
| GSE20123 | IL17D | 53342 | 1 | 14 | 15 | |
| GSE43470 | IL17D | 53342 | 2 | 13 | 28 | |
| GSE46452 | IL17D | 53342 | 0 | 33 | 26 | |
| GSE47630 | IL17D | 53342 | 3 | 26 | 11 | |
| GSE54993 | IL17D | 53342 | 11 | 2 | 57 | |
| GSE54994 | IL17D | 53342 | 1 | 13 | 39 | |
| GSE60625 | IL17D | 53342 | 0 | 3 | 8 | |
| GSE74703 | IL17D | 53342 | 2 | 10 | 24 | |
| GSE74704 | IL17D | 53342 | 0 | 12 | 8 | |
| TCGA | IL17D | 53342 | 6 | 43 | 47 |
Total number of gains: 27; Total number of losses: 184; Total Number of normals: 277.
Somatic mutations of IL17D:
Generating mutation plots.
Highly correlated genes for IL17D:
Showing top 20/681 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL17D | STARD9 | 0.795249 | 4 | 0 | 4 |
| IL17D | FIBIN | 0.791744 | 4 | 0 | 4 |
| IL17D | C16orf89 | 0.776915 | 3 | 0 | 3 |
| IL17D | SLIT3 | 0.775804 | 4 | 0 | 4 |
| IL17D | TIMP3 | 0.775557 | 4 | 0 | 4 |
| IL17D | TMEM178A | 0.76912 | 3 | 0 | 3 |
| IL17D | ZBTB47 | 0.766259 | 4 | 0 | 4 |
| IL17D | MGARP | 0.762504 | 3 | 0 | 3 |
| IL17D | GALNT15 | 0.75861 | 4 | 0 | 3 |
| IL17D | AFF3 | 0.754979 | 3 | 0 | 3 |
| IL17D | NEGR1 | 0.754924 | 6 | 0 | 5 |
| IL17D | PABPC5 | 0.750117 | 5 | 0 | 5 |
| IL17D | TBX5-AS1 | 0.740118 | 4 | 0 | 3 |
| IL17D | MYOC | 0.739712 | 4 | 0 | 3 |
| IL17D | AGTR1 | 0.737528 | 6 | 0 | 5 |
| IL17D | PLA2G5 | 0.735992 | 3 | 0 | 3 |
| IL17D | MYOCD | 0.732819 | 6 | 0 | 5 |
| IL17D | SYNC | 0.730287 | 4 | 0 | 4 |
| IL17D | CCDC110 | 0.728459 | 3 | 0 | 3 |
| IL17D | ABCA6 | 0.728053 | 6 | 0 | 5 |
For details and further investigation, click here
