| Full name: myocilin | Alias Symbol: TIGR|JOAG1 | ||
| Type: protein-coding gene | Cytoband: 1q24.3 | ||
| Entrez ID: 4653 | HGNC ID: HGNC:7610 | Ensembl Gene: ENSG00000034971 | OMIM ID: 601652 |
| Drug and gene relationship at DGIdb | |||
Expression of MYOC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYOC | 4653 | 210155_at | -1.7361 | 0.2533 | |
| GSE20347 | MYOC | 4653 | 210155_at | -0.3320 | 0.1317 | |
| GSE23400 | MYOC | 4653 | 210155_at | -0.9600 | 0.0000 | |
| GSE26886 | MYOC | 4653 | 210155_at | -0.1039 | 0.4599 | |
| GSE29001 | MYOC | 4653 | 210155_at | -0.5399 | 0.0010 | |
| GSE38129 | MYOC | 4653 | 210155_at | -1.5649 | 0.0002 | |
| GSE45670 | MYOC | 4653 | 210155_at | -3.4289 | 0.0000 | |
| GSE53622 | MYOC | 4653 | 27782 | -3.8316 | 0.0000 | |
| GSE53624 | MYOC | 4653 | 27782 | -4.5134 | 0.0000 | |
| GSE63941 | MYOC | 4653 | 210155_at | -0.0715 | 0.6847 | |
| GSE77861 | MYOC | 4653 | 210155_at | -0.0532 | 0.5247 | |
| GSE97050 | MYOC | 4653 | A_23_P23783 | -2.8169 | 0.0781 | |
| SRP064894 | MYOC | 4653 | RNAseq | -3.4097 | 0.0000 | |
| SRP133303 | MYOC | 4653 | RNAseq | -2.5274 | 0.0508 | |
| SRP159526 | MYOC | 4653 | RNAseq | -1.9138 | 0.2426 | |
| SRP219564 | MYOC | 4653 | RNAseq | -0.2196 | 0.8876 | |
| TCGA | MYOC | 4653 | RNAseq | -2.7179 | 0.0006 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by MYOC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYOC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYOC | 4653 | 12 | 1 | 17 | |
| GSE20123 | MYOC | 4653 | 12 | 1 | 17 | |
| GSE43470 | MYOC | 4653 | 7 | 2 | 34 | |
| GSE46452 | MYOC | 4653 | 3 | 1 | 55 | |
| GSE47630 | MYOC | 4653 | 14 | 0 | 26 | |
| GSE54993 | MYOC | 4653 | 0 | 6 | 64 | |
| GSE54994 | MYOC | 4653 | 16 | 0 | 37 | |
| GSE60625 | MYOC | 4653 | 0 | 0 | 11 | |
| GSE74703 | MYOC | 4653 | 7 | 2 | 27 | |
| GSE74704 | MYOC | 4653 | 6 | 0 | 14 | |
| TCGA | MYOC | 4653 | 42 | 3 | 51 |
Total number of gains: 119; Total number of losses: 16; Total Number of normals: 353.
Somatic mutations of MYOC:
Generating mutation plots.
Highly correlated genes for MYOC:
Showing top 20/1113 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYOC | SORCS1 | 0.88005 | 4 | 0 | 4 |
| MYOC | XKR4 | 0.872247 | 5 | 0 | 5 |
| MYOC | DPT | 0.843211 | 9 | 0 | 9 |
| MYOC | UBXN10 | 0.842957 | 3 | 0 | 3 |
| MYOC | CYP21A2 | 0.841167 | 3 | 0 | 3 |
| MYOC | CLEC3B | 0.839028 | 3 | 0 | 3 |
| MYOC | ADAMTSL1 | 0.829931 | 5 | 0 | 5 |
| MYOC | SYNPO2 | 0.8297 | 5 | 0 | 5 |
| MYOC | TMOD1 | 0.822167 | 7 | 0 | 7 |
| MYOC | RCAN2 | 0.819831 | 9 | 0 | 9 |
| MYOC | C1QTNF7 | 0.811264 | 6 | 0 | 5 |
| MYOC | SGCA | 0.808807 | 9 | 0 | 9 |
| MYOC | FENDRR | 0.805797 | 4 | 0 | 4 |
| MYOC | RNF150 | 0.803412 | 5 | 0 | 5 |
| MYOC | PLP1 | 0.803162 | 9 | 0 | 9 |
| MYOC | SLMAP | 0.802679 | 5 | 0 | 5 |
| MYOC | NEGR1 | 0.799497 | 6 | 0 | 5 |
| MYOC | FGL2 | 0.799243 | 8 | 0 | 8 |
| MYOC | SLIT2 | 0.799076 | 8 | 0 | 8 |
| MYOC | ADAMTS9-AS2 | 0.797371 | 4 | 0 | 4 |
For details and further investigation, click here
