| Full name: slit guidance ligand 3 | Alias Symbol: slit2|MEGF5|SLIT1|Slit-3 | ||
| Type: protein-coding gene | Cytoband: 5q34-q35.1 | ||
| Entrez ID: 6586 | HGNC ID: HGNC:11087 | Ensembl Gene: ENSG00000184347 | OMIM ID: 603745 |
| Drug and gene relationship at DGIdb | |||
Expression of SLIT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLIT3 | 6586 | 203812_at | -1.1177 | 0.0481 | |
| GSE20347 | SLIT3 | 6586 | 203812_at | -0.1408 | 0.1221 | |
| GSE23400 | SLIT3 | 6586 | 203812_at | -0.4075 | 0.0000 | |
| GSE26886 | SLIT3 | 6586 | 203812_at | 0.0191 | 0.9412 | |
| GSE29001 | SLIT3 | 6586 | 203812_at | -0.3916 | 0.0498 | |
| GSE38129 | SLIT3 | 6586 | 203813_s_at | -0.3889 | 0.2112 | |
| GSE45670 | SLIT3 | 6586 | 203812_at | -1.7150 | 0.0000 | |
| GSE63941 | SLIT3 | 6586 | 203812_at | -2.3311 | 0.0000 | |
| GSE77861 | SLIT3 | 6586 | 203812_at | -0.2310 | 0.0574 | |
| GSE97050 | SLIT3 | 6586 | A_23_P58588 | -0.3255 | 0.3684 | |
| SRP007169 | SLIT3 | 6586 | RNAseq | 2.2408 | 0.0027 | |
| SRP064894 | SLIT3 | 6586 | RNAseq | -0.7824 | 0.0777 | |
| SRP133303 | SLIT3 | 6586 | RNAseq | -1.3973 | 0.0006 | |
| SRP159526 | SLIT3 | 6586 | RNAseq | -0.9818 | 0.0050 | |
| SRP193095 | SLIT3 | 6586 | RNAseq | 1.2048 | 0.0001 | |
| SRP219564 | SLIT3 | 6586 | RNAseq | -0.0393 | 0.9652 | |
| TCGA | SLIT3 | 6586 | RNAseq | -0.6512 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 4.
Survival by SLIT3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SLIT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLIT3 | 6586 | 1 | 12 | 17 | |
| GSE20123 | SLIT3 | 6586 | 1 | 12 | 17 | |
| GSE43470 | SLIT3 | 6586 | 2 | 8 | 33 | |
| GSE46452 | SLIT3 | 6586 | 0 | 27 | 32 | |
| GSE47630 | SLIT3 | 6586 | 0 | 20 | 20 | |
| GSE54993 | SLIT3 | 6586 | 9 | 2 | 59 | |
| GSE54994 | SLIT3 | 6586 | 2 | 15 | 36 | |
| GSE60625 | SLIT3 | 6586 | 1 | 0 | 10 | |
| GSE74703 | SLIT3 | 6586 | 2 | 6 | 28 | |
| GSE74704 | SLIT3 | 6586 | 0 | 6 | 14 | |
| TCGA | SLIT3 | 6586 | 7 | 38 | 51 |
Total number of gains: 25; Total number of losses: 146; Total Number of normals: 317.
Somatic mutations of SLIT3:
Generating mutation plots.
Highly correlated genes for SLIT3:
Showing top 20/1130 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLIT3 | ANGPTL1 | 0.862891 | 4 | 0 | 4 |
| SLIT3 | ABCA9 | 0.856077 | 3 | 0 | 3 |
| SLIT3 | EBF3 | 0.854727 | 3 | 0 | 3 |
| SLIT3 | INMT | 0.840284 | 4 | 0 | 4 |
| SLIT3 | MEOX2 | 0.82699 | 5 | 0 | 5 |
| SLIT3 | LRFN5 | 0.803259 | 3 | 0 | 3 |
| SLIT3 | MAGI2-AS3 | 0.801148 | 3 | 0 | 3 |
| SLIT3 | TMEM178A | 0.796237 | 3 | 0 | 3 |
| SLIT3 | LINC00968 | 0.786085 | 3 | 0 | 3 |
| SLIT3 | PRICKLE2 | 0.786078 | 4 | 0 | 4 |
| SLIT3 | OMD | 0.784989 | 6 | 0 | 6 |
| SLIT3 | ZBTB47 | 0.783109 | 3 | 0 | 3 |
| SLIT3 | RGN | 0.780205 | 7 | 0 | 7 |
| SLIT3 | RAB9B | 0.779544 | 4 | 0 | 4 |
| SLIT3 | IL17D | 0.775804 | 4 | 0 | 4 |
| SLIT3 | NTN4 | 0.7756 | 3 | 0 | 3 |
| SLIT3 | C7 | 0.775419 | 7 | 0 | 7 |
| SLIT3 | LIFR | 0.773967 | 4 | 0 | 4 |
| SLIT3 | EIF4E3 | 0.769176 | 4 | 0 | 4 |
| SLIT3 | PI16 | 0.766665 | 3 | 0 | 3 |
For details and further investigation, click here
