| Full name: C-C motif chemokine receptor 6 | Alias Symbol: CKR-L3|GPR-CY4|CMKBR6|GPR29|DRY-6|DCR2|BN-1|CD196 | ||
| Type: protein-coding gene | Cytoband: 6q27 | ||
| Entrez ID: 1235 | HGNC ID: HGNC:1607 | Ensembl Gene: ENSG00000112486 | OMIM ID: 601835 |
| Drug and gene relationship at DGIdb | |||
CCR6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CCR6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCR6 | 1235 | 206983_at | -0.4111 | 0.5579 | |
| GSE20347 | CCR6 | 1235 | 206983_at | -0.0876 | 0.3312 | |
| GSE23400 | CCR6 | 1235 | 206983_at | -0.0475 | 0.0106 | |
| GSE26886 | CCR6 | 1235 | 206983_at | -0.6103 | 0.0725 | |
| GSE29001 | CCR6 | 1235 | 206983_at | -0.1016 | 0.4302 | |
| GSE38129 | CCR6 | 1235 | 206983_at | -0.1868 | 0.1117 | |
| GSE45670 | CCR6 | 1235 | 206983_at | -0.2133 | 0.5195 | |
| GSE63941 | CCR6 | 1235 | 206983_at | -0.0186 | 0.8973 | |
| GSE77861 | CCR6 | 1235 | 206983_at | -0.0672 | 0.4492 | |
| GSE97050 | CCR6 | 1235 | A_33_P3313929 | 0.0212 | 0.9469 | |
| SRP064894 | CCR6 | 1235 | RNAseq | -0.2749 | 0.2528 | |
| SRP133303 | CCR6 | 1235 | RNAseq | -0.6697 | 0.0019 | |
| SRP159526 | CCR6 | 1235 | RNAseq | -1.5224 | 0.0733 | |
| SRP193095 | CCR6 | 1235 | RNAseq | -0.5664 | 0.0103 | |
| SRP219564 | CCR6 | 1235 | RNAseq | -0.2014 | 0.7840 | |
| TCGA | CCR6 | 1235 | RNAseq | -0.1192 | 0.5206 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CCR6 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CCR6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCR6 | 1235 | 2 | 6 | 22 | |
| GSE20123 | CCR6 | 1235 | 2 | 6 | 22 | |
| GSE43470 | CCR6 | 1235 | 3 | 0 | 40 | |
| GSE46452 | CCR6 | 1235 | 3 | 10 | 46 | |
| GSE47630 | CCR6 | 1235 | 7 | 7 | 26 | |
| GSE54993 | CCR6 | 1235 | 4 | 3 | 63 | |
| GSE54994 | CCR6 | 1235 | 10 | 8 | 35 | |
| GSE60625 | CCR6 | 1235 | 1 | 1 | 9 | |
| GSE74703 | CCR6 | 1235 | 3 | 0 | 33 | |
| GSE74704 | CCR6 | 1235 | 1 | 3 | 16 | |
| TCGA | CCR6 | 1235 | 14 | 21 | 61 |
Total number of gains: 50; Total number of losses: 65; Total Number of normals: 373.
Somatic mutations of CCR6:
Generating mutation plots.
Highly correlated genes for CCR6:
Showing top 20/74 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCR6 | C3orf35 | 0.749133 | 3 | 0 | 3 |
| CCR6 | BCKDHA | 0.741136 | 3 | 0 | 3 |
| CCR6 | IL23A | 0.726157 | 3 | 0 | 3 |
| CCR6 | FAM189A1 | 0.716388 | 3 | 0 | 3 |
| CCR6 | CD28 | 0.712411 | 3 | 0 | 3 |
| CCR6 | SCN3A | 0.705803 | 3 | 0 | 3 |
| CCR6 | GALNT5 | 0.686471 | 3 | 0 | 3 |
| CCR6 | FETUB | 0.68076 | 3 | 0 | 3 |
| CCR6 | BANK1 | 0.658532 | 6 | 0 | 5 |
| CCR6 | CD52 | 0.657892 | 6 | 0 | 5 |
| CCR6 | ANKDD1A | 0.655297 | 3 | 0 | 3 |
| CCR6 | PTPRCAP | 0.65009 | 6 | 0 | 4 |
| CCR6 | CD3G | 0.649412 | 6 | 0 | 6 |
| CCR6 | ITGAL | 0.641339 | 7 | 0 | 5 |
| CCR6 | TRAF3IP3 | 0.641124 | 5 | 0 | 4 |
| CCR6 | CD72 | 0.629477 | 4 | 0 | 3 |
| CCR6 | HDC | 0.624641 | 6 | 0 | 4 |
| CCR6 | POU1F1 | 0.622818 | 4 | 0 | 3 |
| CCR6 | NLRC3 | 0.622478 | 5 | 0 | 5 |
| CCR6 | LINC01215 | 0.612921 | 4 | 0 | 3 |
For details and further investigation, click here
