| Full name: pleckstrin homology domain containing N1 | Alias Symbol: DKFZP434H2010 | ||
| Type: protein-coding gene | Cytoband: 1p36.33 | ||
| Entrez ID: 84069 | HGNC ID: HGNC:25284 | Ensembl Gene: ENSG00000187583 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHN1 | 84069 | 224125_at | -0.4128 | 0.3793 | |
| GSE26886 | PLEKHN1 | 84069 | 224125_at | -0.3406 | 0.0291 | |
| GSE45670 | PLEKHN1 | 84069 | 224125_at | -0.2136 | 0.1157 | |
| GSE53622 | PLEKHN1 | 84069 | 11881 | -1.2140 | 0.0000 | |
| GSE53624 | PLEKHN1 | 84069 | 11881 | -1.5446 | 0.0000 | |
| GSE63941 | PLEKHN1 | 84069 | 224125_at | -0.0221 | 0.9036 | |
| GSE77861 | PLEKHN1 | 84069 | 224125_at | -0.3509 | 0.0432 | |
| GSE97050 | PLEKHN1 | 84069 | A_23_P23616 | -0.1829 | 0.8080 | |
| SRP007169 | PLEKHN1 | 84069 | RNAseq | -3.7749 | 0.0000 | |
| SRP008496 | PLEKHN1 | 84069 | RNAseq | -3.8828 | 0.0000 | |
| SRP064894 | PLEKHN1 | 84069 | RNAseq | -1.9446 | 0.0000 | |
| SRP133303 | PLEKHN1 | 84069 | RNAseq | -2.3059 | 0.0000 | |
| SRP159526 | PLEKHN1 | 84069 | RNAseq | -3.5508 | 0.0000 | |
| SRP193095 | PLEKHN1 | 84069 | RNAseq | -1.8200 | 0.0000 | |
| SRP219564 | PLEKHN1 | 84069 | RNAseq | -2.6679 | 0.0101 | |
| TCGA | PLEKHN1 | 84069 | RNAseq | 0.7886 | 0.0012 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by PLEKHN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHN1 | 84069 | 3 | 7 | 20 | |
| GSE20123 | PLEKHN1 | 84069 | 3 | 6 | 21 | |
| GSE43470 | PLEKHN1 | 84069 | 1 | 5 | 37 | |
| GSE46452 | PLEKHN1 | 84069 | 7 | 1 | 51 | |
| GSE47630 | PLEKHN1 | 84069 | 8 | 4 | 28 | |
| GSE54993 | PLEKHN1 | 84069 | 2 | 2 | 66 | |
| GSE54994 | PLEKHN1 | 84069 | 15 | 2 | 36 | |
| GSE60625 | PLEKHN1 | 84069 | 0 | 0 | 11 | |
| GSE74703 | PLEKHN1 | 84069 | 1 | 3 | 32 | |
| GSE74704 | PLEKHN1 | 84069 | 3 | 0 | 17 | |
| TCGA | PLEKHN1 | 84069 | 14 | 20 | 62 |
Total number of gains: 57; Total number of losses: 50; Total Number of normals: 381.
Somatic mutations of PLEKHN1:
Generating mutation plots.
Highly correlated genes for PLEKHN1:
Showing top 20/1023 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHN1 | MFSD2B | 0.891411 | 3 | 0 | 3 |
| PLEKHN1 | KRT83 | 0.86297 | 3 | 0 | 3 |
| PLEKHN1 | ARHGAP40 | 0.844182 | 3 | 0 | 3 |
| PLEKHN1 | FAM163B | 0.843272 | 3 | 0 | 3 |
| PLEKHN1 | KRTAP20-1 | 0.838584 | 3 | 0 | 3 |
| PLEKHN1 | OTOP3 | 0.826503 | 3 | 0 | 3 |
| PLEKHN1 | MUC22 | 0.819293 | 3 | 0 | 3 |
| PLEKHN1 | KPRP | 0.793193 | 3 | 0 | 3 |
| PLEKHN1 | RNF222 | 0.782764 | 3 | 0 | 3 |
| PLEKHN1 | KMT2D | 0.781908 | 3 | 0 | 3 |
| PLEKHN1 | ARID5A | 0.779125 | 3 | 0 | 3 |
| PLEKHN1 | NANOS2 | 0.777992 | 4 | 0 | 4 |
| PLEKHN1 | TMPRSS11A | 0.777962 | 3 | 0 | 3 |
| PLEKHN1 | HES5 | 0.777045 | 4 | 0 | 4 |
| PLEKHN1 | KRT72 | 0.7749 | 3 | 0 | 3 |
| PLEKHN1 | SH3GL1 | 0.769038 | 6 | 0 | 6 |
| PLEKHN1 | DEGS2 | 0.767074 | 7 | 0 | 7 |
| PLEKHN1 | C6orf132 | 0.76676 | 7 | 0 | 7 |
| PLEKHN1 | UPK3B | 0.764664 | 3 | 0 | 3 |
| PLEKHN1 | FMN2 | 0.764599 | 3 | 0 | 3 |
For details and further investigation, click here
