| Full name: interleukin 34 | Alias Symbol: MGC34647|IL-34 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 146433 | HGNC ID: HGNC:28529 | Ensembl Gene: ENSG00000157368 | OMIM ID: 612081 |
| Drug and gene relationship at DGIdb | |||
Expression of IL34:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL34 | 146433 | 237046_x_at | -0.1196 | 0.6570 | |
| GSE26886 | IL34 | 146433 | 237046_x_at | 0.0377 | 0.8433 | |
| GSE45670 | IL34 | 146433 | 237046_x_at | -0.1351 | 0.1915 | |
| GSE53622 | IL34 | 146433 | 49871 | -2.6716 | 0.0000 | |
| GSE53624 | IL34 | 146433 | 49871 | -3.1381 | 0.0000 | |
| GSE63941 | IL34 | 146433 | 237046_x_at | 0.1421 | 0.1692 | |
| GSE77861 | IL34 | 146433 | 237046_x_at | -0.2352 | 0.2231 | |
| GSE97050 | IL34 | 146433 | A_23_P100386 | -0.6901 | 0.1927 | |
| SRP007169 | IL34 | 146433 | RNAseq | -5.9039 | 0.0000 | |
| SRP008496 | IL34 | 146433 | RNAseq | -5.1127 | 0.0000 | |
| SRP064894 | IL34 | 146433 | RNAseq | -2.4809 | 0.0000 | |
| SRP133303 | IL34 | 146433 | RNAseq | -2.6427 | 0.0000 | |
| SRP159526 | IL34 | 146433 | RNAseq | -2.4630 | 0.0000 | |
| SRP193095 | IL34 | 146433 | RNAseq | -2.3122 | 0.0000 | |
| SRP219564 | IL34 | 146433 | RNAseq | -2.2947 | 0.0000 | |
| TCGA | IL34 | 146433 | RNAseq | -0.1573 | 0.5479 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by IL34 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL34:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL34 | 146433 | 6 | 1 | 23 | |
| GSE20123 | IL34 | 146433 | 6 | 1 | 23 | |
| GSE43470 | IL34 | 146433 | 2 | 8 | 33 | |
| GSE46452 | IL34 | 146433 | 38 | 1 | 20 | |
| GSE47630 | IL34 | 146433 | 11 | 8 | 21 | |
| GSE54993 | IL34 | 146433 | 2 | 4 | 64 | |
| GSE54994 | IL34 | 146433 | 8 | 10 | 35 | |
| GSE60625 | IL34 | 146433 | 4 | 0 | 7 | |
| GSE74703 | IL34 | 146433 | 2 | 5 | 29 | |
| GSE74704 | IL34 | 146433 | 3 | 0 | 17 | |
| TCGA | IL34 | 146433 | 27 | 12 | 57 |
Total number of gains: 109; Total number of losses: 50; Total Number of normals: 329.
Somatic mutations of IL34:
Generating mutation plots.
Highly correlated genes for IL34:
Showing top 20/1144 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL34 | TEAD3 | 0.802865 | 3 | 0 | 3 |
| IL34 | CA13 | 0.79949 | 3 | 0 | 3 |
| IL34 | SLC10A5 | 0.794807 | 3 | 0 | 3 |
| IL34 | CASC3 | 0.783818 | 3 | 0 | 3 |
| IL34 | MYRIP | 0.774873 | 3 | 0 | 3 |
| IL34 | GPD1L | 0.769005 | 4 | 0 | 4 |
| IL34 | HIGD1A | 0.765762 | 3 | 0 | 3 |
| IL34 | SEMA6C | 0.763789 | 5 | 0 | 5 |
| IL34 | FAM162B | 0.763022 | 3 | 0 | 3 |
| IL34 | CCDC6 | 0.754327 | 4 | 0 | 4 |
| IL34 | RNF11 | 0.753612 | 3 | 0 | 3 |
| IL34 | IL2 | 0.75326 | 3 | 0 | 3 |
| IL34 | ACSM1 | 0.752986 | 3 | 0 | 3 |
| IL34 | EPGN | 0.750723 | 3 | 0 | 3 |
| IL34 | FAM214A | 0.749527 | 3 | 0 | 3 |
| IL34 | CLPX | 0.747851 | 3 | 0 | 3 |
| IL34 | PGM2 | 0.746661 | 3 | 0 | 3 |
| IL34 | RNF208 | 0.744948 | 5 | 0 | 5 |
| IL34 | CD1E | 0.743638 | 6 | 0 | 6 |
| IL34 | RERGL | 0.741882 | 3 | 0 | 3 |
For details and further investigation, click here
