| Full name: coiled-coil domain containing 6 | Alias Symbol: PTC|TPC|H4 | ||
| Type: protein-coding gene | Cytoband: 10q21.2 | ||
| Entrez ID: 8030 | HGNC ID: HGNC:18782 | Ensembl Gene: ENSG00000108091 | OMIM ID: 601985 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CCDC6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05216 | Thyroid cancer |
Expression of CCDC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCDC6 | 8030 | 225010_at | -0.2868 | 0.5925 | |
| GSE20347 | CCDC6 | 8030 | 204716_at | -1.5163 | 0.0000 | |
| GSE23400 | CCDC6 | 8030 | 204716_at | -0.9069 | 0.0000 | |
| GSE26886 | CCDC6 | 8030 | 225010_at | -1.9257 | 0.0000 | |
| GSE29001 | CCDC6 | 8030 | 204716_at | -1.4235 | 0.0000 | |
| GSE38129 | CCDC6 | 8030 | 204716_at | -1.1665 | 0.0000 | |
| GSE45670 | CCDC6 | 8030 | 225010_at | -0.6170 | 0.0004 | |
| GSE53622 | CCDC6 | 8030 | 21367 | -1.4467 | 0.0000 | |
| GSE53624 | CCDC6 | 8030 | 21367 | -1.3739 | 0.0000 | |
| GSE63941 | CCDC6 | 8030 | 225010_at | 0.1890 | 0.7597 | |
| GSE77861 | CCDC6 | 8030 | 225010_at | -1.0660 | 0.0047 | |
| GSE97050 | CCDC6 | 8030 | A_33_P3396159 | -0.3102 | 0.3794 | |
| SRP007169 | CCDC6 | 8030 | RNAseq | -2.2469 | 0.0000 | |
| SRP008496 | CCDC6 | 8030 | RNAseq | -2.1112 | 0.0000 | |
| SRP064894 | CCDC6 | 8030 | RNAseq | -1.3420 | 0.0000 | |
| SRP133303 | CCDC6 | 8030 | RNAseq | -0.9217 | 0.0000 | |
| SRP159526 | CCDC6 | 8030 | RNAseq | -1.2658 | 0.0042 | |
| SRP193095 | CCDC6 | 8030 | RNAseq | -1.3450 | 0.0000 | |
| SRP219564 | CCDC6 | 8030 | RNAseq | -0.9049 | 0.0146 | |
| TCGA | CCDC6 | 8030 | RNAseq | -0.0966 | 0.0529 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by CCDC6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCDC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCDC6 | 8030 | 2 | 6 | 22 | |
| GSE20123 | CCDC6 | 8030 | 2 | 6 | 22 | |
| GSE43470 | CCDC6 | 8030 | 2 | 5 | 36 | |
| GSE46452 | CCDC6 | 8030 | 1 | 11 | 47 | |
| GSE47630 | CCDC6 | 8030 | 4 | 12 | 24 | |
| GSE54993 | CCDC6 | 8030 | 9 | 0 | 61 | |
| GSE54994 | CCDC6 | 8030 | 3 | 9 | 41 | |
| GSE60625 | CCDC6 | 8030 | 0 | 0 | 11 | |
| GSE74703 | CCDC6 | 8030 | 2 | 3 | 31 | |
| GSE74704 | CCDC6 | 8030 | 1 | 4 | 15 | |
| TCGA | CCDC6 | 8030 | 10 | 23 | 63 |
Total number of gains: 36; Total number of losses: 79; Total Number of normals: 373.
Somatic mutations of CCDC6:
Generating mutation plots.
Highly correlated genes for CCDC6:
Showing top 20/2036 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCDC6 | SRP68 | 0.833743 | 3 | 0 | 3 |
| CCDC6 | VSIG2 | 0.813044 | 6 | 0 | 6 |
| CCDC6 | RASSF5 | 0.809562 | 7 | 0 | 7 |
| CCDC6 | C18orf25 | 0.805408 | 11 | 0 | 11 |
| CCDC6 | RAB11A | 0.804353 | 11 | 0 | 11 |
| CCDC6 | RBM20 | 0.804029 | 4 | 0 | 4 |
| CCDC6 | CASC3 | 0.803742 | 3 | 0 | 3 |
| CCDC6 | ACAA1 | 0.80263 | 8 | 0 | 8 |
| CCDC6 | CHP1 | 0.800347 | 10 | 0 | 10 |
| CCDC6 | KIAA1211L | 0.797414 | 6 | 0 | 6 |
| CCDC6 | CA13 | 0.79645 | 3 | 0 | 3 |
| CCDC6 | GYS2 | 0.794849 | 10 | 0 | 10 |
| CCDC6 | ZNF416 | 0.794604 | 5 | 0 | 5 |
| CCDC6 | RANBP9 | 0.792676 | 11 | 0 | 11 |
| CCDC6 | SASH1 | 0.790796 | 11 | 0 | 11 |
| CCDC6 | SH3GLB1 | 0.787028 | 10 | 0 | 10 |
| CCDC6 | LRRFIP2 | 0.786695 | 11 | 0 | 10 |
| CCDC6 | MFSD5 | 0.786038 | 11 | 0 | 11 |
| CCDC6 | ZFAND2B | 0.785713 | 7 | 0 | 7 |
| CCDC6 | HSD17B4 | 0.78543 | 10 | 0 | 10 |
For details and further investigation, click here
