| Full name: HIG1 hypoxia inducible domain family member 1A | Alias Symbol: HIG1|DKFZP564K247|RCF1A | ||
| Type: protein-coding gene | Cytoband: 3p22.1 | ||
| Entrez ID: 25994 | HGNC ID: HGNC:29527 | Ensembl Gene: ENSG00000181061 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of HIGD1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HIGD1A | 25994 | 217845_x_at | -0.7249 | 0.0621 | |
| GSE20347 | HIGD1A | 25994 | 217845_x_at | -1.2942 | 0.0000 | |
| GSE23400 | HIGD1A | 25994 | 217845_x_at | -0.8545 | 0.0000 | |
| GSE26886 | HIGD1A | 25994 | 217845_x_at | -1.4965 | 0.0000 | |
| GSE29001 | HIGD1A | 25994 | 217845_x_at | -1.0258 | 0.0001 | |
| GSE38129 | HIGD1A | 25994 | 217845_x_at | -1.1885 | 0.0000 | |
| GSE45670 | HIGD1A | 25994 | 217845_x_at | -0.4024 | 0.0201 | |
| GSE53622 | HIGD1A | 25994 | 151647 | -1.2134 | 0.0000 | |
| GSE53624 | HIGD1A | 25994 | 151647 | -1.2887 | 0.0000 | |
| GSE63941 | HIGD1A | 25994 | 217845_x_at | -0.4076 | 0.2258 | |
| GSE77861 | HIGD1A | 25994 | 217845_x_at | -0.9118 | 0.0192 | |
| GSE97050 | HIGD1A | 25994 | A_24_P200162 | -0.7393 | 0.0660 | |
| SRP007169 | HIGD1A | 25994 | RNAseq | -2.4128 | 0.0000 | |
| SRP008496 | HIGD1A | 25994 | RNAseq | -2.0550 | 0.0000 | |
| SRP064894 | HIGD1A | 25994 | RNAseq | -1.4294 | 0.0000 | |
| SRP133303 | HIGD1A | 25994 | RNAseq | -0.7669 | 0.0000 | |
| SRP159526 | HIGD1A | 25994 | RNAseq | -1.3467 | 0.0002 | |
| SRP193095 | HIGD1A | 25994 | RNAseq | -1.5875 | 0.0000 | |
| SRP219564 | HIGD1A | 25994 | RNAseq | -1.2775 | 0.0007 | |
| TCGA | HIGD1A | 25994 | RNAseq | -0.3138 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by HIGD1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HIGD1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HIGD1A | 25994 | 0 | 19 | 11 | |
| GSE20123 | HIGD1A | 25994 | 0 | 19 | 11 | |
| GSE43470 | HIGD1A | 25994 | 0 | 21 | 22 | |
| GSE46452 | HIGD1A | 25994 | 2 | 17 | 40 | |
| GSE47630 | HIGD1A | 25994 | 1 | 24 | 15 | |
| GSE54993 | HIGD1A | 25994 | 7 | 2 | 61 | |
| GSE54994 | HIGD1A | 25994 | 1 | 34 | 18 | |
| GSE60625 | HIGD1A | 25994 | 5 | 0 | 6 | |
| GSE74703 | HIGD1A | 25994 | 0 | 17 | 19 | |
| GSE74704 | HIGD1A | 25994 | 0 | 13 | 7 | |
| TCGA | HIGD1A | 25994 | 1 | 71 | 24 |
Total number of gains: 17; Total number of losses: 237; Total Number of normals: 234.
Somatic mutations of HIGD1A:
Generating mutation plots.
Highly correlated genes for HIGD1A:
Showing top 20/1759 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HIGD1A | CLIC3 | 0.815411 | 8 | 0 | 8 |
| HIGD1A | CYSRT1 | 0.811536 | 6 | 0 | 6 |
| HIGD1A | UBL3 | 0.806115 | 10 | 0 | 10 |
| HIGD1A | PPP1R3C | 0.80496 | 12 | 0 | 11 |
| HIGD1A | PRSS27 | 0.803191 | 6 | 0 | 6 |
| HIGD1A | CAPN14 | 0.80181 | 6 | 0 | 6 |
| HIGD1A | EMC3 | 0.800459 | 10 | 0 | 10 |
| HIGD1A | SCEL | 0.800408 | 10 | 0 | 10 |
| HIGD1A | GDPD3 | 0.797965 | 10 | 0 | 10 |
| HIGD1A | ECM1 | 0.79714 | 10 | 0 | 10 |
| HIGD1A | PDCD6IP | 0.794689 | 11 | 0 | 11 |
| HIGD1A | GPD1L | 0.794339 | 11 | 0 | 11 |
| HIGD1A | MAL | 0.792462 | 10 | 0 | 10 |
| HIGD1A | CWH43 | 0.791612 | 10 | 0 | 10 |
| HIGD1A | TMPRSS11B | 0.790888 | 6 | 0 | 6 |
| HIGD1A | EMP1 | 0.790282 | 10 | 0 | 10 |
| HIGD1A | BRK1 | 0.789398 | 7 | 0 | 7 |
| HIGD1A | A2ML1 | 0.788649 | 6 | 0 | 6 |
| HIGD1A | ACAA1 | 0.785916 | 9 | 0 | 8 |
| HIGD1A | EPB41L3 | 0.785082 | 11 | 0 | 11 |
For details and further investigation, click here
