| Full name: acyl-CoA synthetase medium chain family member 1 | Alias Symbol: MACS1 | ||
| Type: protein-coding gene | Cytoband: 16p12.3 | ||
| Entrez ID: 116285 | HGNC ID: HGNC:18049 | Ensembl Gene: ENSG00000166743 | OMIM ID: 614357 |
| Drug and gene relationship at DGIdb | |||
Expression of ACSM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACSM1 | 116285 | 234197_at | 0.0183 | 0.9509 | |
| GSE20347 | ACSM1 | 116285 | 215432_at | -0.0827 | 0.1681 | |
| GSE23400 | ACSM1 | 116285 | 215432_at | -0.1273 | 0.0001 | |
| GSE26886 | ACSM1 | 116285 | 234197_at | -0.0786 | 0.3870 | |
| GSE29001 | ACSM1 | 116285 | 215432_at | -0.2483 | 0.0384 | |
| GSE38129 | ACSM1 | 116285 | 215432_at | -0.1919 | 0.0003 | |
| GSE45670 | ACSM1 | 116285 | 215432_at | -0.2275 | 0.0140 | |
| GSE53622 | ACSM1 | 116285 | 5761 | -2.4137 | 0.0000 | |
| GSE53624 | ACSM1 | 116285 | 5761 | -2.2698 | 0.0000 | |
| GSE63941 | ACSM1 | 116285 | 234197_at | 0.0660 | 0.6294 | |
| GSE77861 | ACSM1 | 116285 | 234197_at | 0.0653 | 0.6151 | |
| GSE97050 | ACSM1 | 116285 | A_23_P106933 | -0.2566 | 0.5488 | |
| SRP133303 | ACSM1 | 116285 | RNAseq | 0.6099 | 0.4460 | |
| SRP159526 | ACSM1 | 116285 | RNAseq | -2.0619 | 0.0265 | |
| TCGA | ACSM1 | 116285 | RNAseq | -2.9936 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by ACSM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACSM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACSM1 | 116285 | 6 | 3 | 21 | |
| GSE20123 | ACSM1 | 116285 | 6 | 2 | 22 | |
| GSE43470 | ACSM1 | 116285 | 3 | 3 | 37 | |
| GSE46452 | ACSM1 | 116285 | 38 | 1 | 20 | |
| GSE47630 | ACSM1 | 116285 | 11 | 6 | 23 | |
| GSE54993 | ACSM1 | 116285 | 3 | 5 | 62 | |
| GSE54994 | ACSM1 | 116285 | 3 | 10 | 40 | |
| GSE60625 | ACSM1 | 116285 | 4 | 0 | 7 | |
| GSE74703 | ACSM1 | 116285 | 3 | 2 | 31 | |
| GSE74704 | ACSM1 | 116285 | 3 | 1 | 16 | |
| TCGA | ACSM1 | 116285 | 19 | 13 | 64 |
Total number of gains: 99; Total number of losses: 46; Total Number of normals: 343.
Somatic mutations of ACSM1:
Generating mutation plots.
Highly correlated genes for ACSM1:
Showing top 20/325 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACSM1 | MUC22 | 0.894275 | 3 | 0 | 3 |
| ACSM1 | FAM163B | 0.796806 | 3 | 0 | 3 |
| ACSM1 | ARID5A | 0.785742 | 4 | 0 | 4 |
| ACSM1 | NCCRP1 | 0.756922 | 3 | 0 | 3 |
| ACSM1 | IL34 | 0.752986 | 3 | 0 | 3 |
| ACSM1 | MFSD2B | 0.752062 | 3 | 0 | 3 |
| ACSM1 | RNF133 | 0.751046 | 3 | 0 | 3 |
| ACSM1 | WNK4 | 0.747477 | 3 | 0 | 3 |
| ACSM1 | HES5 | 0.743183 | 3 | 0 | 3 |
| ACSM1 | OR10G8 | 0.742814 | 3 | 0 | 3 |
| ACSM1 | KRTAP20-1 | 0.740077 | 3 | 0 | 3 |
| ACSM1 | OR2Z1 | 0.73922 | 3 | 0 | 3 |
| ACSM1 | CYP3A7 | 0.737635 | 3 | 0 | 3 |
| ACSM1 | SH3BGRL2 | 0.733925 | 3 | 0 | 3 |
| ACSM1 | KRTAP3-2 | 0.731653 | 4 | 0 | 4 |
| ACSM1 | SLC22A12 | 0.726853 | 3 | 0 | 3 |
| ACSM1 | OTOP3 | 0.724547 | 3 | 0 | 3 |
| ACSM1 | TEN1 | 0.713843 | 3 | 0 | 3 |
| ACSM1 | KPRP | 0.712281 | 3 | 0 | 3 |
| ACSM1 | RNF222 | 0.707696 | 3 | 0 | 3 |
For details and further investigation, click here
