| Full name: inosine monophosphate dehydrogenase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 3615 | HGNC ID: HGNC:6053 | Ensembl Gene: ENSG00000178035 | OMIM ID: 146691 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of IMPDH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IMPDH2 | 3615 | 201892_s_at | -0.0959 | 0.8361 | |
| GSE20347 | IMPDH2 | 3615 | 201892_s_at | -0.5856 | 0.0084 | |
| GSE23400 | IMPDH2 | 3615 | 201892_s_at | -0.0769 | 0.4061 | |
| GSE26886 | IMPDH2 | 3615 | 201892_s_at | -0.8624 | 0.0043 | |
| GSE29001 | IMPDH2 | 3615 | 201892_s_at | -0.5296 | 0.2148 | |
| GSE38129 | IMPDH2 | 3615 | 201892_s_at | -0.3088 | 0.1032 | |
| GSE45670 | IMPDH2 | 3615 | 201892_s_at | -0.3882 | 0.0026 | |
| GSE53622 | IMPDH2 | 3615 | 24467 | -0.4894 | 0.0000 | |
| GSE53624 | IMPDH2 | 3615 | 24467 | -0.4095 | 0.0000 | |
| GSE63941 | IMPDH2 | 3615 | 201892_s_at | 0.4592 | 0.1632 | |
| GSE77861 | IMPDH2 | 3615 | 201892_s_at | -0.4935 | 0.1487 | |
| GSE97050 | IMPDH2 | 3615 | A_33_P3214298 | -0.0149 | 0.9731 | |
| SRP007169 | IMPDH2 | 3615 | RNAseq | -0.0652 | 0.8780 | |
| SRP008496 | IMPDH2 | 3615 | RNAseq | -0.2667 | 0.3002 | |
| SRP064894 | IMPDH2 | 3615 | RNAseq | -0.2946 | 0.2142 | |
| SRP133303 | IMPDH2 | 3615 | RNAseq | -0.6529 | 0.0000 | |
| SRP159526 | IMPDH2 | 3615 | RNAseq | -0.6861 | 0.0654 | |
| SRP193095 | IMPDH2 | 3615 | RNAseq | -0.7898 | 0.0000 | |
| SRP219564 | IMPDH2 | 3615 | RNAseq | -0.0215 | 0.9624 | |
| TCGA | IMPDH2 | 3615 | RNAseq | -0.0111 | 0.8512 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IMPDH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IMPDH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IMPDH2 | 3615 | 0 | 18 | 12 | |
| GSE20123 | IMPDH2 | 3615 | 0 | 19 | 11 | |
| GSE43470 | IMPDH2 | 3615 | 0 | 18 | 25 | |
| GSE46452 | IMPDH2 | 3615 | 2 | 16 | 41 | |
| GSE47630 | IMPDH2 | 3615 | 1 | 24 | 15 | |
| GSE54993 | IMPDH2 | 3615 | 6 | 2 | 62 | |
| GSE54994 | IMPDH2 | 3615 | 0 | 36 | 17 | |
| GSE60625 | IMPDH2 | 3615 | 5 | 0 | 6 | |
| GSE74703 | IMPDH2 | 3615 | 0 | 14 | 22 | |
| GSE74704 | IMPDH2 | 3615 | 0 | 12 | 8 | |
| TCGA | IMPDH2 | 3615 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of IMPDH2:
Generating mutation plots.
Highly correlated genes for IMPDH2:
Showing top 20/652 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IMPDH2 | ZCCHC10 | 0.762908 | 3 | 0 | 3 |
| IMPDH2 | PRDX4 | 0.753791 | 3 | 0 | 3 |
| IMPDH2 | AIFM1 | 0.752949 | 3 | 0 | 3 |
| IMPDH2 | IMPACT | 0.746392 | 3 | 0 | 3 |
| IMPDH2 | CAPRIN1 | 0.740623 | 3 | 0 | 3 |
| IMPDH2 | MIS18A | 0.732379 | 3 | 0 | 3 |
| IMPDH2 | GTF3C6 | 0.730655 | 4 | 0 | 4 |
| IMPDH2 | GFM2 | 0.730204 | 3 | 0 | 3 |
| IMPDH2 | DAD1 | 0.729724 | 4 | 0 | 4 |
| IMPDH2 | ZDHHC5 | 0.724787 | 3 | 0 | 3 |
| IMPDH2 | ZNF212 | 0.72309 | 3 | 0 | 3 |
| IMPDH2 | FBXW2 | 0.719995 | 3 | 0 | 3 |
| IMPDH2 | BTBD1 | 0.716487 | 4 | 0 | 4 |
| IMPDH2 | FNBP1 | 0.714303 | 3 | 0 | 3 |
| IMPDH2 | HOOK3 | 0.707754 | 3 | 0 | 3 |
| IMPDH2 | MED14 | 0.706851 | 3 | 0 | 3 |
| IMPDH2 | GLOD4 | 0.701386 | 4 | 0 | 4 |
| IMPDH2 | DNAJB6 | 0.69931 | 4 | 0 | 4 |
| IMPDH2 | CYB5B | 0.698485 | 3 | 0 | 3 |
| IMPDH2 | TMEM107 | 0.698341 | 3 | 0 | 3 |
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