| Full name: defender against cell death 1 | Alias Symbol: OST2 | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 1603 | HGNC ID: HGNC:2664 | Ensembl Gene: ENSG00000129562 | OMIM ID: 600243 |
| Drug and gene relationship at DGIdb | |||
Expression of DAD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DAD1 | 1603 | 200046_at | -0.2050 | 0.7100 | |
| GSE20347 | DAD1 | 1603 | 200046_at | -0.3106 | 0.2073 | |
| GSE23400 | DAD1 | 1603 | 200046_at | 0.2519 | 0.0003 | |
| GSE26886 | DAD1 | 1603 | 200046_at | -0.4615 | 0.0303 | |
| GSE29001 | DAD1 | 1603 | 200046_at | 0.0667 | 0.8582 | |
| GSE38129 | DAD1 | 1603 | 200046_at | -0.0254 | 0.9065 | |
| GSE45670 | DAD1 | 1603 | 200046_at | 0.1585 | 0.1706 | |
| GSE53622 | DAD1 | 1603 | 145451 | 0.1421 | 0.0369 | |
| GSE53624 | DAD1 | 1603 | 145451 | 0.2122 | 0.0000 | |
| GSE63941 | DAD1 | 1603 | 200046_at | -0.3677 | 0.4424 | |
| GSE77861 | DAD1 | 1603 | 200046_at | -0.0628 | 0.8934 | |
| GSE97050 | DAD1 | 1603 | A_23_P106056 | 0.4980 | 0.1581 | |
| SRP007169 | DAD1 | 1603 | RNAseq | -0.5585 | 0.0941 | |
| SRP008496 | DAD1 | 1603 | RNAseq | -0.6481 | 0.0011 | |
| SRP064894 | DAD1 | 1603 | RNAseq | 0.2581 | 0.3167 | |
| SRP133303 | DAD1 | 1603 | RNAseq | 0.3379 | 0.2017 | |
| SRP159526 | DAD1 | 1603 | RNAseq | -0.1082 | 0.5988 | |
| SRP193095 | DAD1 | 1603 | RNAseq | -0.4374 | 0.0212 | |
| SRP219564 | DAD1 | 1603 | RNAseq | -0.0979 | 0.7323 | |
| TCGA | DAD1 | 1603 | RNAseq | 0.0087 | 0.8648 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DAD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DAD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DAD1 | 1603 | 9 | 3 | 18 | |
| GSE20123 | DAD1 | 1603 | 9 | 3 | 18 | |
| GSE43470 | DAD1 | 1603 | 7 | 1 | 35 | |
| GSE46452 | DAD1 | 1603 | 18 | 2 | 39 | |
| GSE47630 | DAD1 | 1603 | 11 | 10 | 19 | |
| GSE54993 | DAD1 | 1603 | 3 | 11 | 56 | |
| GSE54994 | DAD1 | 1603 | 18 | 5 | 30 | |
| GSE60625 | DAD1 | 1603 | 0 | 2 | 9 | |
| GSE74703 | DAD1 | 1603 | 6 | 1 | 29 | |
| GSE74704 | DAD1 | 1603 | 4 | 2 | 14 | |
| TCGA | DAD1 | 1603 | 25 | 17 | 54 |
Total number of gains: 110; Total number of losses: 57; Total Number of normals: 321.
Somatic mutations of DAD1:
Generating mutation plots.
Highly correlated genes for DAD1:
Showing top 20/345 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DAD1 | RTN3 | 0.811513 | 3 | 0 | 3 |
| DAD1 | CD82 | 0.795736 | 3 | 0 | 3 |
| DAD1 | C14orf119 | 0.731993 | 4 | 0 | 4 |
| DAD1 | EFNB2 | 0.730095 | 3 | 0 | 3 |
| DAD1 | IMPDH2 | 0.729724 | 4 | 0 | 4 |
| DAD1 | ARL2BP | 0.728277 | 4 | 0 | 4 |
| DAD1 | MCFD2 | 0.720366 | 3 | 0 | 3 |
| DAD1 | CDV3 | 0.718478 | 4 | 0 | 4 |
| DAD1 | NEDD8 | 0.712828 | 13 | 0 | 11 |
| DAD1 | MRPL52 | 0.711049 | 8 | 0 | 7 |
| DAD1 | BNIP3 | 0.710368 | 3 | 0 | 3 |
| DAD1 | TPM3 | 0.701305 | 4 | 0 | 4 |
| DAD1 | PGGT1B | 0.699884 | 4 | 0 | 4 |
| DAD1 | DIAPH1 | 0.696796 | 3 | 0 | 3 |
| DAD1 | PRELID1 | 0.690523 | 4 | 0 | 3 |
| DAD1 | NLRP3 | 0.68672 | 3 | 0 | 3 |
| DAD1 | RNF145 | 0.685852 | 4 | 0 | 3 |
| DAD1 | GLUD2 | 0.683646 | 5 | 0 | 4 |
| DAD1 | DNAJB6 | 0.68327 | 3 | 0 | 3 |
| DAD1 | C1orf56 | 0.682571 | 3 | 0 | 3 |
For details and further investigation, click here
