| Full name: troponin T1, slow skeletal type | Alias Symbol: ANM|STNT|TNT|TNTS|FLJ98147|MGC104241|NEM5 | ||
| Type: protein-coding gene | Cytoband: 19q13.4 | ||
| Entrez ID: 7138 | HGNC ID: HGNC:11948 | Ensembl Gene: ENSG00000105048 | OMIM ID: 191041 |
| Drug and gene relationship at DGIdb | |||
Expression of TNNT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNNT1 | 7138 | 213201_s_at | 0.1921 | 0.8752 | |
| GSE20347 | TNNT1 | 7138 | 213201_s_at | 0.4341 | 0.0531 | |
| GSE23400 | TNNT1 | 7138 | 213201_s_at | 0.2831 | 0.0012 | |
| GSE26886 | TNNT1 | 7138 | 213201_s_at | 2.5358 | 0.0000 | |
| GSE29001 | TNNT1 | 7138 | 213201_s_at | 0.6418 | 0.3037 | |
| GSE38129 | TNNT1 | 7138 | 213201_s_at | 1.1267 | 0.0001 | |
| GSE45670 | TNNT1 | 7138 | 213201_s_at | 1.1761 | 0.0341 | |
| GSE53622 | TNNT1 | 7138 | 131061 | 0.7511 | 0.0094 | |
| GSE53624 | TNNT1 | 7138 | 131061 | 1.1654 | 0.0000 | |
| GSE63941 | TNNT1 | 7138 | 213201_s_at | 3.9733 | 0.0001 | |
| GSE77861 | TNNT1 | 7138 | 213201_s_at | 0.6431 | 0.1222 | |
| GSE97050 | TNNT1 | 7138 | A_33_P3397865 | -0.5061 | 0.7403 | |
| SRP064894 | TNNT1 | 7138 | RNAseq | 1.8224 | 0.0003 | |
| SRP133303 | TNNT1 | 7138 | RNAseq | 2.6118 | 0.0000 | |
| SRP159526 | TNNT1 | 7138 | RNAseq | 1.3509 | 0.0040 | |
| SRP219564 | TNNT1 | 7138 | RNAseq | 2.3951 | 0.0147 | |
| TCGA | TNNT1 | 7138 | RNAseq | 2.9844 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by TNNT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNNT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNNT1 | 7138 | 3 | 4 | 23 | |
| GSE20123 | TNNT1 | 7138 | 3 | 3 | 24 | |
| GSE43470 | TNNT1 | 7138 | 3 | 11 | 29 | |
| GSE46452 | TNNT1 | 7138 | 45 | 1 | 13 | |
| GSE47630 | TNNT1 | 7138 | 8 | 6 | 26 | |
| GSE54993 | TNNT1 | 7138 | 17 | 4 | 49 | |
| GSE54994 | TNNT1 | 7138 | 4 | 13 | 36 | |
| GSE60625 | TNNT1 | 7138 | 9 | 0 | 2 | |
| GSE74703 | TNNT1 | 7138 | 3 | 7 | 26 | |
| GSE74704 | TNNT1 | 7138 | 3 | 1 | 16 | |
| TCGA | TNNT1 | 7138 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of TNNT1:
Generating mutation plots.
Highly correlated genes for TNNT1:
Showing top 20/544 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNNT1 | KANK4 | 0.72407 | 4 | 0 | 4 |
| TNNT1 | LINC00460 | 0.713118 | 4 | 0 | 4 |
| TNNT1 | PREP | 0.708901 | 3 | 0 | 3 |
| TNNT1 | RNASEH2C | 0.7088 | 3 | 0 | 3 |
| TNNT1 | SPIRE1 | 0.706706 | 5 | 0 | 5 |
| TNNT1 | CERCAM | 0.692073 | 4 | 0 | 4 |
| TNNT1 | SFN | 0.684034 | 4 | 0 | 3 |
| TNNT1 | C8orf37 | 0.679299 | 3 | 0 | 3 |
| TNNT1 | DNAAF3 | 0.677917 | 6 | 0 | 6 |
| TNNT1 | DMRTC2 | 0.667549 | 3 | 0 | 3 |
| TNNT1 | RGL3 | 0.664496 | 3 | 0 | 3 |
| TNNT1 | USP40 | 0.663574 | 3 | 0 | 3 |
| TNNT1 | C2orf68 | 0.661988 | 3 | 0 | 3 |
| TNNT1 | ZIC2 | 0.660194 | 4 | 0 | 3 |
| TNNT1 | CCDC91 | 0.659948 | 3 | 0 | 3 |
| TNNT1 | ZBTB8A | 0.659685 | 3 | 0 | 3 |
| TNNT1 | ORC3 | 0.659196 | 4 | 0 | 3 |
| TNNT1 | ANKRD26 | 0.658941 | 3 | 0 | 3 |
| TNNT1 | NOSIP | 0.658742 | 6 | 0 | 5 |
| TNNT1 | DTX3 | 0.654963 | 3 | 0 | 3 |
For details and further investigation, click here
