SH3BP1

 

Full name: SH3 domain binding protein 1 Alias Symbol: ARHGAP43
Type: protein-coding gene Cytoband: 22q13.1
Entrez ID: 23616 HGNC ID: HGNC:10824 Ensembl Gene: ENSG00000100092 OMIM ID: 617368
Drug and gene relationship at DGIdb

 

Expression of SH3BP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SH3BP1 23616 213633_at 0.3819 0.3095
GSE20347 SH3BP1 23616 213633_at 0.0207 0.8592
GSE23400 SH3BP1 23616 213633_at 0.0386 0.5853
GSE26886 SH3BP1 23616 213633_at 0.5496 0.0004
GSE29001 SH3BP1 23616 213633_at -0.3934 0.0093
GSE38129 SH3BP1 23616 213633_at 0.1000 0.4117
GSE45670 SH3BP1 23616 213633_at 0.1588 0.0609
GSE53622 SH3BP1 23616 68839 0.3178 0.0001
GSE53624 SH3BP1 23616 99789 0.1220 0.1787
GSE63941 SH3BP1 23616 213633_at 0.9871 0.0003
GSE77861 SH3BP1 23616 213633_at 0.0049 0.9856
GSE97050 SH3BP1 23616 A_33_P3286334 0.5410 0.3026
SRP007169 SH3BP1 23616 RNAseq -0.8289 0.0389
SRP008496 SH3BP1 23616 RNAseq -1.1904 0.0001
SRP064894 SH3BP1 23616 RNAseq 0.1119 0.7033
SRP133303 SH3BP1 23616 RNAseq -0.3436 0.0846
SRP159526 SH3BP1 23616 RNAseq -0.4200 0.1663
SRP193095 SH3BP1 23616 RNAseq 0.2176 0.1901
SRP219564 SH3BP1 23616 RNAseq -0.4448 0.5486
TCGA SH3BP1 23616 RNAseq 0.8183 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by SH3BP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SH3BP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SH3BP1 23616 6 5 19
GSE20123 SH3BP1 23616 6 4 20
GSE43470 SH3BP1 23616 4 6 33
GSE46452 SH3BP1 23616 32 2 25
GSE47630 SH3BP1 23616 9 4 27
GSE54993 SH3BP1 23616 3 6 61
GSE54994 SH3BP1 23616 9 8 36
GSE60625 SH3BP1 23616 5 0 6
GSE74703 SH3BP1 23616 4 4 28
GSE74704 SH3BP1 23616 3 2 15
TCGA SH3BP1 23616 27 15 54

Total number of gains: 108; Total number of losses: 56; Total Number of normals: 324.  

 

Somatic mutations of SH3BP1:

 

Generating mutation plots.

 

Highly correlated genes for SH3BP1:

 

Showing top 20/654 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SH3BP1TMEM1020.778983404
SH3BP1SERPINB50.729937404
SH3BP1CD79A0.728695303
SH3BP1SMPD30.726347303
SH3BP1ACY10.723149303
SH3BP1GIGYF10.714248404
SH3BP1MAPK8IP20.712571303
SH3BP1ANO90.703346403
SH3BP1SRL0.690799303
SH3BP1ENTPD20.690182303
SH3BP1GGN0.686401303
SH3BP1GLI10.68555404
SH3BP1C1QL10.682549505
SH3BP1ZNF7470.68012403
SH3BP1FERMT10.679456504
SH3BP1MDFI0.678485606
SH3BP1TRMT2B0.673498303
SH3BP1TRAPPC10.670384504
SH3BP1GANAB0.667644303
SH3BP1PPP1R350.665892303

For details and further investigation, click here