| Full name: iron-sulfur cluster assembly enzyme | Alias Symbol: ISU2|hnifU|IscU | ||
| Type: protein-coding gene | Cytoband: 12q23.3 | ||
| Entrez ID: 23479 | HGNC ID: HGNC:29882 | Ensembl Gene: ENSG00000136003 | OMIM ID: 611911 |
| Drug and gene relationship at DGIdb | |||
Expression of ISCU:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ISCU | 23479 | 209075_s_at | -0.2444 | 0.6223 | |
| GSE20347 | ISCU | 23479 | 209075_s_at | 0.1271 | 0.3340 | |
| GSE23400 | ISCU | 23479 | 209075_s_at | 0.0063 | 0.9516 | |
| GSE26886 | ISCU | 23479 | 209075_s_at | 0.4933 | 0.0012 | |
| GSE29001 | ISCU | 23479 | 209075_s_at | 0.1274 | 0.4689 | |
| GSE38129 | ISCU | 23479 | 209075_s_at | -0.1121 | 0.5279 | |
| GSE45670 | ISCU | 23479 | 209075_s_at | -0.4013 | 0.0021 | |
| GSE53622 | ISCU | 23479 | 114607 | -0.3893 | 0.0000 | |
| GSE53624 | ISCU | 23479 | 114607 | -0.1464 | 0.0091 | |
| GSE63941 | ISCU | 23479 | 209075_s_at | -0.6970 | 0.0347 | |
| GSE77861 | ISCU | 23479 | 209075_s_at | 0.0202 | 0.9404 | |
| GSE97050 | ISCU | 23479 | A_23_P340158 | -0.5154 | 0.1782 | |
| SRP007169 | ISCU | 23479 | RNAseq | 0.2817 | 0.4795 | |
| SRP008496 | ISCU | 23479 | RNAseq | 0.1803 | 0.4310 | |
| SRP064894 | ISCU | 23479 | RNAseq | -0.1135 | 0.4987 | |
| SRP133303 | ISCU | 23479 | RNAseq | -0.0318 | 0.8176 | |
| SRP159526 | ISCU | 23479 | RNAseq | -0.1548 | 0.4201 | |
| SRP193095 | ISCU | 23479 | RNAseq | -0.1427 | 0.2095 | |
| SRP219564 | ISCU | 23479 | RNAseq | -0.3127 | 0.5303 | |
| TCGA | ISCU | 23479 | RNAseq | -0.2404 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ISCU expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ISCU:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ISCU | 23479 | 5 | 3 | 22 | |
| GSE20123 | ISCU | 23479 | 5 | 3 | 22 | |
| GSE43470 | ISCU | 23479 | 2 | 1 | 40 | |
| GSE46452 | ISCU | 23479 | 9 | 1 | 49 | |
| GSE47630 | ISCU | 23479 | 9 | 1 | 30 | |
| GSE54993 | ISCU | 23479 | 0 | 5 | 65 | |
| GSE54994 | ISCU | 23479 | 4 | 2 | 47 | |
| GSE60625 | ISCU | 23479 | 0 | 0 | 11 | |
| GSE74703 | ISCU | 23479 | 2 | 0 | 34 | |
| GSE74704 | ISCU | 23479 | 2 | 2 | 16 | |
| TCGA | ISCU | 23479 | 21 | 10 | 65 |
Total number of gains: 59; Total number of losses: 28; Total Number of normals: 401.
Somatic mutations of ISCU:
Generating mutation plots.
Highly correlated genes for ISCU:
Showing top 20/368 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ISCU | RPRM | 0.769271 | 3 | 0 | 3 |
| ISCU | SLC8A1 | 0.767818 | 4 | 0 | 4 |
| ISCU | ADAMTSL3 | 0.731376 | 6 | 0 | 5 |
| ISCU | NR3C2 | 0.723921 | 5 | 0 | 5 |
| ISCU | GPM6A | 0.720092 | 5 | 0 | 5 |
| ISCU | ARHGAP6 | 0.711972 | 6 | 0 | 6 |
| ISCU | ZNF777 | 0.698582 | 3 | 0 | 3 |
| ISCU | CPXM2 | 0.697648 | 3 | 0 | 3 |
| ISCU | ZNF428 | 0.692331 | 5 | 0 | 4 |
| ISCU | C14orf28 | 0.691554 | 3 | 0 | 3 |
| ISCU | GKAP1 | 0.690282 | 4 | 0 | 3 |
| ISCU | KLHL26 | 0.689326 | 4 | 0 | 3 |
| ISCU | KBTBD12 | 0.688165 | 4 | 0 | 3 |
| ISCU | DISP1 | 0.676364 | 5 | 0 | 4 |
| ISCU | RASSF8 | 0.676118 | 3 | 0 | 3 |
| ISCU | JADE1 | 0.668974 | 5 | 0 | 4 |
| ISCU | PPP1R9A | 0.667548 | 4 | 0 | 3 |
| ISCU | BEND7 | 0.663108 | 6 | 0 | 5 |
| ISCU | RGMB | 0.661983 | 4 | 0 | 4 |
| ISCU | USP27X | 0.658983 | 5 | 0 | 5 |
For details and further investigation, click here
