| Full name: reprimo, TP53 dependent G2 arrest mediator homolog | Alias Symbol: FLJ90327|REPRIMO | ||
| Type: protein-coding gene | Cytoband: 2q23.3 | ||
| Entrez ID: 56475 | HGNC ID: HGNC:24201 | Ensembl Gene: ENSG00000177519 | OMIM ID: 612171 |
| Drug and gene relationship at DGIdb | |||
RPRM involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway |
Expression of RPRM:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPRM | 56475 | 219370_at | -0.1022 | 0.9700 | |
| GSE20347 | RPRM | 56475 | 219370_at | 0.4503 | 0.0005 | |
| GSE23400 | RPRM | 56475 | 219370_at | 0.0058 | 0.9244 | |
| GSE26886 | RPRM | 56475 | 219370_at | 0.6355 | 0.0179 | |
| GSE29001 | RPRM | 56475 | 219370_at | 0.3646 | 0.2394 | |
| GSE38129 | RPRM | 56475 | 219370_at | 0.2051 | 0.3108 | |
| GSE45670 | RPRM | 56475 | 219370_at | 0.2092 | 0.6149 | |
| GSE53622 | RPRM | 56475 | 75911 | 0.3204 | 0.0140 | |
| GSE53624 | RPRM | 56475 | 75911 | 0.7737 | 0.0000 | |
| GSE63941 | RPRM | 56475 | 219370_at | 0.4471 | 0.5415 | |
| GSE77861 | RPRM | 56475 | 219370_at | 0.2548 | 0.3105 | |
| GSE97050 | RPRM | 56475 | A_23_P5370 | -0.2161 | 0.6305 | |
| SRP007169 | RPRM | 56475 | RNAseq | 3.3170 | 0.0068 | |
| SRP133303 | RPRM | 56475 | RNAseq | 2.1464 | 0.0001 | |
| SRP159526 | RPRM | 56475 | RNAseq | 3.9392 | 0.0000 | |
| SRP219564 | RPRM | 56475 | RNAseq | -0.2896 | 0.8353 | |
| TCGA | RPRM | 56475 | RNAseq | -1.3377 | 0.0002 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by RPRM expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPRM:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPRM | 56475 | 4 | 2 | 24 | |
| GSE20123 | RPRM | 56475 | 4 | 2 | 24 | |
| GSE43470 | RPRM | 56475 | 3 | 1 | 39 | |
| GSE46452 | RPRM | 56475 | 1 | 4 | 54 | |
| GSE47630 | RPRM | 56475 | 5 | 3 | 32 | |
| GSE54993 | RPRM | 56475 | 0 | 5 | 65 | |
| GSE54994 | RPRM | 56475 | 11 | 2 | 40 | |
| GSE60625 | RPRM | 56475 | 0 | 3 | 8 | |
| GSE74703 | RPRM | 56475 | 2 | 1 | 33 | |
| GSE74704 | RPRM | 56475 | 3 | 0 | 17 | |
| TCGA | RPRM | 56475 | 20 | 10 | 66 |
Total number of gains: 53; Total number of losses: 33; Total Number of normals: 402.
Somatic mutations of RPRM:
Generating mutation plots.
Highly correlated genes for RPRM:
Showing top 20/128 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPRM | NRK | 0.816677 | 3 | 0 | 3 |
| RPRM | PPP1R12C | 0.786329 | 3 | 0 | 3 |
| RPRM | ISCU | 0.769271 | 3 | 0 | 3 |
| RPRM | GTF2IRD2B | 0.732948 | 3 | 0 | 3 |
| RPRM | SLC35G1 | 0.707769 | 3 | 0 | 3 |
| RPRM | TMEM9 | 0.700887 | 3 | 0 | 3 |
| RPRM | RETN | 0.669049 | 3 | 0 | 3 |
| RPRM | SHISA6 | 0.664661 | 4 | 0 | 3 |
| RPRM | PCSK1N | 0.663587 | 3 | 0 | 3 |
| RPRM | SETD1B | 0.656946 | 4 | 0 | 3 |
| RPRM | ALKBH5 | 0.649165 | 4 | 0 | 3 |
| RPRM | VAMP4 | 0.645022 | 4 | 0 | 3 |
| RPRM | ESRRG | 0.642134 | 3 | 0 | 3 |
| RPRM | ZNF559 | 0.642083 | 4 | 0 | 3 |
| RPRM | PAX6 | 0.640682 | 4 | 0 | 3 |
| RPRM | ZNF527 | 0.635084 | 4 | 0 | 3 |
| RPRM | GTF2IRD2 | 0.619494 | 4 | 0 | 3 |
| RPRM | MPP3 | 0.618717 | 4 | 0 | 3 |
| RPRM | IRGQ | 0.617833 | 4 | 0 | 3 |
| RPRM | AMIGO1 | 0.613169 | 4 | 0 | 3 |
For details and further investigation, click here
