| Full name: inositol-trisphosphate 3-kinase A | Alias Symbol: IP3KA|IP3-3KA | ||
| Type: protein-coding gene | Cytoband: 15q15.1 | ||
| Entrez ID: 3706 | HGNC ID: HGNC:6178 | Ensembl Gene: ENSG00000137825 | OMIM ID: 147521 |
| Drug and gene relationship at DGIdb | |||
ITPKA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway |
Expression of ITPKA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITPKA | 3706 | 205874_at | 0.1846 | 0.6388 | |
| GSE20347 | ITPKA | 3706 | 205874_at | 0.0101 | 0.9077 | |
| GSE23400 | ITPKA | 3706 | 205874_at | -0.0947 | 0.0099 | |
| GSE26886 | ITPKA | 3706 | 205874_at | 0.4726 | 0.0018 | |
| GSE29001 | ITPKA | 3706 | 205874_at | 0.1095 | 0.5429 | |
| GSE38129 | ITPKA | 3706 | 205874_at | 0.0642 | 0.6806 | |
| GSE45670 | ITPKA | 3706 | 205874_at | 0.1043 | 0.4062 | |
| GSE53622 | ITPKA | 3706 | 91457 | 1.1627 | 0.0000 | |
| GSE53624 | ITPKA | 3706 | 91457 | 1.7059 | 0.0000 | |
| GSE63941 | ITPKA | 3706 | 205874_at | 0.2138 | 0.4385 | |
| GSE77861 | ITPKA | 3706 | 205874_at | -0.0047 | 0.9703 | |
| GSE97050 | ITPKA | 3706 | A_23_P65918 | 0.3780 | 0.2085 | |
| SRP007169 | ITPKA | 3706 | RNAseq | 2.7030 | 0.0148 | |
| SRP159526 | ITPKA | 3706 | RNAseq | 3.1330 | 0.0000 | |
| TCGA | ITPKA | 3706 | RNAseq | -0.7850 | 0.0003 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ITPKA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITPKA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITPKA | 3706 | 3 | 6 | 21 | |
| GSE20123 | ITPKA | 3706 | 3 | 6 | 21 | |
| GSE43470 | ITPKA | 3706 | 4 | 5 | 34 | |
| GSE46452 | ITPKA | 3706 | 3 | 7 | 49 | |
| GSE47630 | ITPKA | 3706 | 8 | 11 | 21 | |
| GSE54993 | ITPKA | 3706 | 4 | 6 | 60 | |
| GSE54994 | ITPKA | 3706 | 5 | 7 | 41 | |
| GSE60625 | ITPKA | 3706 | 4 | 0 | 7 | |
| GSE74703 | ITPKA | 3706 | 4 | 4 | 28 | |
| GSE74704 | ITPKA | 3706 | 2 | 4 | 14 | |
| TCGA | ITPKA | 3706 | 11 | 18 | 67 |
Total number of gains: 51; Total number of losses: 74; Total Number of normals: 363.
Somatic mutations of ITPKA:
Generating mutation plots.
Highly correlated genes for ITPKA:
Showing top 20/234 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITPKA | IL24 | 0.693149 | 3 | 0 | 3 |
| ITPKA | RCCD1 | 0.69013 | 4 | 0 | 4 |
| ITPKA | SORCS2 | 0.680258 | 3 | 0 | 3 |
| ITPKA | OR4D1 | 0.67883 | 3 | 0 | 3 |
| ITPKA | KRT25 | 0.67448 | 3 | 0 | 3 |
| ITPKA | SIX1 | 0.673988 | 3 | 0 | 3 |
| ITPKA | CDK2 | 0.656119 | 3 | 0 | 3 |
| ITPKA | CRYGC | 0.648774 | 5 | 0 | 4 |
| ITPKA | WDR90 | 0.646049 | 4 | 0 | 4 |
| ITPKA | PXYLP1 | 0.641925 | 3 | 0 | 3 |
| ITPKA | PAX8 | 0.6357 | 3 | 0 | 3 |
| ITPKA | ATCAY | 0.630751 | 3 | 0 | 3 |
| ITPKA | PRKAR1B | 0.628914 | 4 | 0 | 3 |
| ITPKA | HAUS8 | 0.627591 | 5 | 0 | 5 |
| ITPKA | KRT35 | 0.626368 | 4 | 0 | 3 |
| ITPKA | VWA8-AS1 | 0.625402 | 3 | 0 | 3 |
| ITPKA | CMC2 | 0.623824 | 3 | 0 | 3 |
| ITPKA | CMSS1 | 0.617455 | 3 | 0 | 3 |
| ITPKA | FANCG | 0.61675 | 4 | 0 | 3 |
| ITPKA | BCL2L12 | 0.616747 | 4 | 0 | 3 |
For details and further investigation, click here
