| Full name: SIX homeobox 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q23.1 | ||
| Entrez ID: 6495 | HGNC ID: HGNC:10887 | Ensembl Gene: ENSG00000126778 | OMIM ID: 601205 |
| Drug and gene relationship at DGIdb | |||
Expression of SIX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIX1 | 6495 | 228347_at | 2.5257 | 0.0838 | |
| GSE20347 | SIX1 | 6495 | 205817_at | 1.0466 | 0.0000 | |
| GSE23400 | SIX1 | 6495 | 205817_at | 0.2184 | 0.0002 | |
| GSE26886 | SIX1 | 6495 | 205817_at | 0.6592 | 0.0001 | |
| GSE29001 | SIX1 | 6495 | 205817_at | 0.3635 | 0.0292 | |
| GSE38129 | SIX1 | 6495 | 205817_at | 1.1689 | 0.0000 | |
| GSE45670 | SIX1 | 6495 | 228347_at | 2.2862 | 0.0011 | |
| GSE53622 | SIX1 | 6495 | 37495 | 3.6800 | 0.0000 | |
| GSE53624 | SIX1 | 6495 | 37495 | 4.0328 | 0.0000 | |
| GSE63941 | SIX1 | 6495 | 228347_at | -0.0342 | 0.9819 | |
| GSE77861 | SIX1 | 6495 | 205817_at | 0.4522 | 0.0122 | |
| GSE97050 | SIX1 | 6495 | A_23_P76914 | 1.1441 | 0.1785 | |
| SRP007169 | SIX1 | 6495 | RNAseq | 6.8648 | 0.0000 | |
| SRP133303 | SIX1 | 6495 | RNAseq | 3.8564 | 0.0000 | |
| SRP159526 | SIX1 | 6495 | RNAseq | 5.5883 | 0.0000 | |
| SRP219564 | SIX1 | 6495 | RNAseq | 5.5995 | 0.0000 | |
| TCGA | SIX1 | 6495 | RNAseq | 1.9130 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by SIX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIX1 | 6495 | 9 | 3 | 18 | |
| GSE20123 | SIX1 | 6495 | 8 | 3 | 19 | |
| GSE43470 | SIX1 | 6495 | 8 | 2 | 33 | |
| GSE46452 | SIX1 | 6495 | 16 | 3 | 40 | |
| GSE47630 | SIX1 | 6495 | 11 | 9 | 20 | |
| GSE54993 | SIX1 | 6495 | 3 | 9 | 58 | |
| GSE54994 | SIX1 | 6495 | 19 | 4 | 30 | |
| GSE60625 | SIX1 | 6495 | 0 | 2 | 9 | |
| GSE74703 | SIX1 | 6495 | 7 | 2 | 27 | |
| GSE74704 | SIX1 | 6495 | 4 | 2 | 14 | |
| TCGA | SIX1 | 6495 | 32 | 14 | 50 |
Total number of gains: 117; Total number of losses: 53; Total Number of normals: 318.
Somatic mutations of SIX1:
Generating mutation plots.
Highly correlated genes for SIX1:
Showing top 20/1659 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIX1 | PAX5 | 0.780894 | 3 | 0 | 3 |
| SIX1 | SNAP47 | 0.76409 | 3 | 0 | 3 |
| SIX1 | UHRF1 | 0.751795 | 7 | 0 | 7 |
| SIX1 | PNPT1 | 0.745693 | 6 | 0 | 6 |
| SIX1 | SLC19A1 | 0.743595 | 3 | 0 | 3 |
| SIX1 | CDCA5 | 0.742442 | 5 | 0 | 5 |
| SIX1 | CDCA2 | 0.739348 | 4 | 0 | 4 |
| SIX1 | ZIC5 | 0.733647 | 4 | 0 | 4 |
| SIX1 | SIX4 | 0.730722 | 9 | 0 | 8 |
| SIX1 | YDJC | 0.726398 | 7 | 0 | 7 |
| SIX1 | RAD51AP1 | 0.72154 | 8 | 0 | 8 |
| SIX1 | CMSS1 | 0.718876 | 6 | 0 | 6 |
| SIX1 | MEX3D | 0.714881 | 4 | 0 | 4 |
| SIX1 | WDR54 | 0.710017 | 6 | 0 | 5 |
| SIX1 | MYBL2 | 0.709322 | 11 | 0 | 9 |
| SIX1 | GORAB | 0.708753 | 6 | 0 | 6 |
| SIX1 | WDR66 | 0.705701 | 7 | 0 | 6 |
| SIX1 | MTBP | 0.705208 | 5 | 0 | 5 |
| SIX1 | CENPW | 0.704942 | 6 | 0 | 6 |
| SIX1 | KCNS2 | 0.704719 | 3 | 0 | 3 |
For details and further investigation, click here
