CDK2

 

Full name: cyclin dependent kinase 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 12q13.2
Entrez ID: 1017 HGNC ID: HGNC:1771 Ensembl Gene: ENSG00000123374 OMIM ID: 116953
Drug and gene relationship at DGIdb
Screen Evidence:

 

CDK2 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04115p53 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa05161Hepatitis B
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa05222Small cell lung cancer

 

Expression of CDK2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDK2 1017 204252_at 0.5318 0.1935
GSE20347 CDK2 1017 204252_at 0.9234 0.0000
GSE23400 CDK2 1017 204252_at 0.8023 0.0000
GSE26886 CDK2 1017 204252_at -0.7788 0.0026
GSE29001 CDK2 1017 204252_at 0.7058 0.0025
GSE38129 CDK2 1017 204252_at 0.9503 0.0000
GSE45670 CDK2 1017 204252_at 0.5355 0.0024
GSE53622 CDK2 1017 25043 0.7211 0.0000
GSE53624 CDK2 1017 25043 0.5580 0.0000
GSE63941 CDK2 1017 204252_at 1.3636 0.0081
GSE77861 CDK2 1017 204252_at 0.5429 0.0189
GSE97050 CDK2 1017 A_23_P98898 0.4552 0.2608
SRP007169 CDK2 1017 RNAseq 1.2281 0.0023
SRP008496 CDK2 1017 RNAseq 1.1581 0.0001
SRP064894 CDK2 1017 RNAseq 0.8087 0.0007
SRP133303 CDK2 1017 RNAseq 1.3268 0.0000
SRP159526 CDK2 1017 RNAseq 0.6537 0.0378
SRP193095 CDK2 1017 RNAseq 0.7967 0.0000
SRP219564 CDK2 1017 RNAseq 0.3859 0.2025
TCGA CDK2 1017 RNAseq 0.3811 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by CDK2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDK2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDK2 1017 6 2 22
GSE20123 CDK2 1017 6 1 23
GSE43470 CDK2 1017 4 0 39
GSE46452 CDK2 1017 8 1 50
GSE47630 CDK2 1017 10 2 28
GSE54993 CDK2 1017 0 5 65
GSE54994 CDK2 1017 4 1 48
GSE60625 CDK2 1017 0 0 11
GSE74703 CDK2 1017 4 0 32
GSE74704 CDK2 1017 4 1 15
TCGA CDK2 1017 15 10 71

Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.  

 

Somatic mutations of CDK2:

 

Generating mutation plots.

 

Highly correlated genes for CDK2:

 

Showing top 20/293 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDK2CDC60.764373909
CDK2MCM20.7468512012
CDK2KIF4A0.72747812012
CDK2RFC40.72278411011
CDK2FEN10.7219581009
CDK2GINS20.71513212010
CDK2POC1A0.711804707
CDK2TK10.71056112011
CDK2CDC450.70764611010
CDK2TIMELESS0.7057861109
CDK2BUB1B0.7010751009
CDK2AURKB0.70031611010
CDK2MCM70.69739712010
CDK2TPX20.69661511010
CDK2MCM50.69539411010
CDK2STIL0.69367610010
CDK2CKS20.69298211011
CDK2FOXM10.69277512010
CDK2CDCA80.68637613012
CDK2APLN0.685096303

For details and further investigation, click here