| Full name: intersectin 2 | Alias Symbol: KIAA1256|SWAP|SH3P18|SWA|PRO2015 | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 50618 | HGNC ID: HGNC:6184 | Ensembl Gene: ENSG00000198399 | OMIM ID: 604464 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ITSN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITSN2 | 50618 | 209898_x_at | -0.5076 | 0.0801 | |
| GSE20347 | ITSN2 | 50618 | 209898_x_at | -1.0311 | 0.0000 | |
| GSE23400 | ITSN2 | 50618 | 209898_x_at | -0.8068 | 0.0000 | |
| GSE26886 | ITSN2 | 50618 | 209898_x_at | -1.3950 | 0.0000 | |
| GSE29001 | ITSN2 | 50618 | 209898_x_at | -0.6409 | 0.0061 | |
| GSE38129 | ITSN2 | 50618 | 209898_x_at | -1.0087 | 0.0000 | |
| GSE45670 | ITSN2 | 50618 | 209898_x_at | -0.2699 | 0.1557 | |
| GSE53622 | ITSN2 | 50618 | 13137 | -0.9445 | 0.0000 | |
| GSE53624 | ITSN2 | 50618 | 54947 | -0.9797 | 0.0000 | |
| GSE63941 | ITSN2 | 50618 | 209898_x_at | -0.1328 | 0.7870 | |
| GSE77861 | ITSN2 | 50618 | 209898_x_at | -0.7741 | 0.0058 | |
| GSE97050 | ITSN2 | 50618 | A_33_P3416350 | -0.4202 | 0.2423 | |
| SRP007169 | ITSN2 | 50618 | RNAseq | -1.4022 | 0.0057 | |
| SRP008496 | ITSN2 | 50618 | RNAseq | -1.4667 | 0.0000 | |
| SRP064894 | ITSN2 | 50618 | RNAseq | -1.5514 | 0.0000 | |
| SRP133303 | ITSN2 | 50618 | RNAseq | -0.8950 | 0.0000 | |
| SRP159526 | ITSN2 | 50618 | RNAseq | -1.3336 | 0.0005 | |
| SRP193095 | ITSN2 | 50618 | RNAseq | -1.1345 | 0.0000 | |
| SRP219564 | ITSN2 | 50618 | RNAseq | -1.4102 | 0.0040 | |
| TCGA | ITSN2 | 50618 | RNAseq | -0.2045 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by ITSN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITSN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITSN2 | 50618 | 11 | 2 | 17 | |
| GSE20123 | ITSN2 | 50618 | 11 | 2 | 17 | |
| GSE43470 | ITSN2 | 50618 | 2 | 1 | 40 | |
| GSE46452 | ITSN2 | 50618 | 3 | 4 | 52 | |
| GSE47630 | ITSN2 | 50618 | 8 | 0 | 32 | |
| GSE54993 | ITSN2 | 50618 | 0 | 7 | 63 | |
| GSE54994 | ITSN2 | 50618 | 10 | 0 | 43 | |
| GSE60625 | ITSN2 | 50618 | 0 | 3 | 8 | |
| GSE74703 | ITSN2 | 50618 | 2 | 0 | 34 | |
| GSE74704 | ITSN2 | 50618 | 9 | 1 | 10 | |
| TCGA | ITSN2 | 50618 | 36 | 3 | 57 |
Total number of gains: 92; Total number of losses: 23; Total Number of normals: 373.
Somatic mutations of ITSN2:
Generating mutation plots.
Highly correlated genes for ITSN2:
Showing top 20/1484 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITSN2 | PRSS27 | 0.813234 | 6 | 0 | 6 |
| ITSN2 | VSIG10L | 0.802344 | 6 | 0 | 6 |
| ITSN2 | SASH1 | 0.80198 | 11 | 0 | 11 |
| ITSN2 | CCNG2 | 0.796347 | 11 | 0 | 11 |
| ITSN2 | CAPN14 | 0.795825 | 6 | 0 | 6 |
| ITSN2 | CYSRT1 | 0.790146 | 6 | 0 | 6 |
| ITSN2 | FMO2 | 0.789303 | 11 | 0 | 11 |
| ITSN2 | FCHO2 | 0.785579 | 8 | 0 | 7 |
| ITSN2 | RMND5B | 0.783899 | 11 | 0 | 11 |
| ITSN2 | CYP2J2 | 0.781749 | 10 | 0 | 10 |
| ITSN2 | SPNS2 | 0.780955 | 5 | 0 | 5 |
| ITSN2 | NT5C2 | 0.779612 | 11 | 0 | 11 |
| ITSN2 | FAM214A | 0.778062 | 6 | 0 | 6 |
| ITSN2 | TRIP10 | 0.774018 | 11 | 0 | 11 |
| ITSN2 | FLG-AS1 | 0.773089 | 6 | 0 | 6 |
| ITSN2 | STX19 | 0.771806 | 6 | 0 | 6 |
| ITSN2 | USP6NL | 0.770939 | 11 | 0 | 11 |
| ITSN2 | PADI1 | 0.770927 | 8 | 0 | 8 |
| ITSN2 | ECM1 | 0.77045 | 10 | 0 | 10 |
| ITSN2 | SCEL | 0.769664 | 10 | 0 | 10 |
For details and further investigation, click here
