| Full name: flavin containing dimethylaniline monoxygenase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q24.3 | ||
| Entrez ID: 2327 | HGNC ID: HGNC:3770 | Ensembl Gene: ENSG00000094963 | OMIM ID: 603955 |
| Drug and gene relationship at DGIdb | |||
Expression of FMO2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FMO2 | 2327 | 228268_at | -2.1762 | 0.0446 | |
| GSE20347 | FMO2 | 2327 | 211726_s_at | -3.7691 | 0.0000 | |
| GSE23400 | FMO2 | 2327 | 211726_s_at | -2.3828 | 0.0000 | |
| GSE26886 | FMO2 | 2327 | 211726_s_at | -5.2261 | 0.0000 | |
| GSE29001 | FMO2 | 2327 | 211726_s_at | -3.5162 | 0.0000 | |
| GSE38129 | FMO2 | 2327 | 211726_s_at | -3.0896 | 0.0000 | |
| GSE45670 | FMO2 | 2327 | 228268_at | -0.8598 | 0.3539 | |
| GSE53622 | FMO2 | 2327 | 16286 | -3.3122 | 0.0000 | |
| GSE53624 | FMO2 | 2327 | 16286 | -3.8644 | 0.0000 | |
| GSE63941 | FMO2 | 2327 | 228268_at | -2.4537 | 0.0003 | |
| GSE77861 | FMO2 | 2327 | 228268_at | -3.1549 | 0.0042 | |
| GSE97050 | FMO2 | 2327 | A_33_P3275702 | -1.8722 | 0.0708 | |
| SRP007169 | FMO2 | 2327 | RNAseq | -6.2249 | 0.0000 | |
| SRP008496 | FMO2 | 2327 | RNAseq | -7.0563 | 0.0000 | |
| SRP064894 | FMO2 | 2327 | RNAseq | -3.8655 | 0.0000 | |
| SRP133303 | FMO2 | 2327 | RNAseq | -3.1640 | 0.0000 | |
| SRP159526 | FMO2 | 2327 | RNAseq | -4.3148 | 0.0000 | |
| SRP193095 | FMO2 | 2327 | RNAseq | -2.8706 | 0.0000 | |
| SRP219564 | FMO2 | 2327 | RNAseq | -3.4566 | 0.0000 | |
| TCGA | FMO2 | 2327 | RNAseq | -0.2696 | 0.3272 |
Upregulated datasets: 0; Downregulated datasets: 17.
Survival by FMO2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FMO2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FMO2 | 2327 | 12 | 1 | 17 | |
| GSE20123 | FMO2 | 2327 | 12 | 1 | 17 | |
| GSE43470 | FMO2 | 2327 | 7 | 2 | 34 | |
| GSE46452 | FMO2 | 2327 | 3 | 1 | 55 | |
| GSE47630 | FMO2 | 2327 | 14 | 0 | 26 | |
| GSE54993 | FMO2 | 2327 | 0 | 6 | 64 | |
| GSE54994 | FMO2 | 2327 | 16 | 0 | 37 | |
| GSE60625 | FMO2 | 2327 | 0 | 0 | 11 | |
| GSE74703 | FMO2 | 2327 | 7 | 2 | 27 | |
| GSE74704 | FMO2 | 2327 | 6 | 0 | 14 | |
| TCGA | FMO2 | 2327 | 43 | 3 | 50 |
Total number of gains: 120; Total number of losses: 16; Total Number of normals: 352.
Somatic mutations of FMO2:
Generating mutation plots.
Highly correlated genes for FMO2:
Showing top 20/1682 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FMO2 | SCEL | 0.877299 | 10 | 0 | 10 |
| FMO2 | SPINK7 | 0.874421 | 6 | 0 | 6 |
| FMO2 | TMPRSS11E | 0.865084 | 10 | 0 | 10 |
| FMO2 | CYSRT1 | 0.855694 | 6 | 0 | 6 |
| FMO2 | CLCA4 | 0.854473 | 11 | 0 | 10 |
| FMO2 | FCHO2 | 0.849051 | 7 | 0 | 7 |
| FMO2 | VSIG10L | 0.847774 | 6 | 0 | 6 |
| FMO2 | CRNN | 0.842684 | 11 | 0 | 10 |
| FMO2 | FAM214A | 0.840855 | 6 | 0 | 6 |
| FMO2 | CRISP3 | 0.838771 | 11 | 0 | 11 |
| FMO2 | SPINK5 | 0.834879 | 11 | 0 | 10 |
| FMO2 | SERPINB1 | 0.832812 | 11 | 0 | 11 |
| FMO2 | MUC15 | 0.831004 | 6 | 0 | 6 |
| FMO2 | ENDOU | 0.830069 | 11 | 0 | 11 |
| FMO2 | ANXA9 | 0.824928 | 11 | 0 | 11 |
| FMO2 | PPL | 0.820393 | 11 | 0 | 11 |
| FMO2 | RHCG | 0.819663 | 10 | 0 | 10 |
| FMO2 | SLURP1 | 0.818246 | 11 | 0 | 10 |
| FMO2 | CRCT1 | 0.816251 | 10 | 0 | 10 |
| FMO2 | CCNG2 | 0.815722 | 11 | 0 | 11 |
For details and further investigation, click here
