| Full name: 5'-nucleotidase, cytosolic II | Alias Symbol: PNT5|GMP|cN-II|SPG65 | ||
| Type: protein-coding gene | Cytoband: 10q24.32-q24.33 | ||
| Entrez ID: 22978 | HGNC ID: HGNC:8022 | Ensembl Gene: ENSG00000076685 | OMIM ID: 600417 |
| Drug and gene relationship at DGIdb | |||
Expression of NT5C2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NT5C2 | 22978 | 209155_s_at | -0.6948 | 0.2519 | |
| GSE20347 | NT5C2 | 22978 | 209155_s_at | -1.2660 | 0.0000 | |
| GSE23400 | NT5C2 | 22978 | 209155_s_at | -0.9845 | 0.0000 | |
| GSE26886 | NT5C2 | 22978 | 209155_s_at | -1.5596 | 0.0000 | |
| GSE29001 | NT5C2 | 22978 | 209155_s_at | -1.2089 | 0.0001 | |
| GSE38129 | NT5C2 | 22978 | 209155_s_at | -0.9198 | 0.0000 | |
| GSE45670 | NT5C2 | 22978 | 209155_s_at | -0.2053 | 0.4384 | |
| GSE53622 | NT5C2 | 22978 | 38146 | -1.0012 | 0.0000 | |
| GSE53624 | NT5C2 | 22978 | 38146 | -1.4470 | 0.0000 | |
| GSE63941 | NT5C2 | 22978 | 209155_s_at | -0.4977 | 0.2752 | |
| GSE77861 | NT5C2 | 22978 | 209155_s_at | -1.4292 | 0.0016 | |
| GSE97050 | NT5C2 | 22978 | A_33_P3255354 | -0.2487 | 0.5786 | |
| SRP007169 | NT5C2 | 22978 | RNAseq | -2.4408 | 0.0000 | |
| SRP008496 | NT5C2 | 22978 | RNAseq | -2.3315 | 0.0000 | |
| SRP064894 | NT5C2 | 22978 | RNAseq | -1.8030 | 0.0000 | |
| SRP133303 | NT5C2 | 22978 | RNAseq | -1.0488 | 0.0000 | |
| SRP159526 | NT5C2 | 22978 | RNAseq | -2.0039 | 0.0000 | |
| SRP193095 | NT5C2 | 22978 | RNAseq | -1.3617 | 0.0000 | |
| SRP219564 | NT5C2 | 22978 | RNAseq | -1.2087 | 0.0130 | |
| TCGA | NT5C2 | 22978 | RNAseq | -0.0056 | 0.9217 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by NT5C2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NT5C2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NT5C2 | 22978 | 2 | 9 | 19 | |
| GSE20123 | NT5C2 | 22978 | 2 | 8 | 20 | |
| GSE43470 | NT5C2 | 22978 | 0 | 8 | 35 | |
| GSE46452 | NT5C2 | 22978 | 0 | 11 | 48 | |
| GSE47630 | NT5C2 | 22978 | 2 | 14 | 24 | |
| GSE54993 | NT5C2 | 22978 | 8 | 0 | 62 | |
| GSE54994 | NT5C2 | 22978 | 1 | 11 | 41 | |
| GSE60625 | NT5C2 | 22978 | 0 | 0 | 11 | |
| GSE74703 | NT5C2 | 22978 | 0 | 5 | 31 | |
| GSE74704 | NT5C2 | 22978 | 1 | 4 | 15 | |
| TCGA | NT5C2 | 22978 | 5 | 30 | 61 |
Total number of gains: 21; Total number of losses: 100; Total Number of normals: 367.
Somatic mutations of NT5C2:
Generating mutation plots.
Highly correlated genes for NT5C2:
Showing top 20/1705 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NT5C2 | TTC9 | 0.847226 | 11 | 0 | 11 |
| NT5C2 | BLNK | 0.844257 | 11 | 0 | 11 |
| NT5C2 | ARHGAP27 | 0.829765 | 7 | 0 | 7 |
| NT5C2 | VPS4B | 0.826968 | 11 | 0 | 11 |
| NT5C2 | C18orf25 | 0.82633 | 11 | 0 | 11 |
| NT5C2 | ZDHHC13 | 0.824508 | 11 | 0 | 11 |
| NT5C2 | SPNS2 | 0.824098 | 5 | 0 | 5 |
| NT5C2 | CYSRT1 | 0.82102 | 6 | 0 | 6 |
| NT5C2 | CLIC3 | 0.818684 | 9 | 0 | 9 |
| NT5C2 | ANXA9 | 0.81622 | 11 | 0 | 11 |
| NT5C2 | RAB25 | 0.814082 | 11 | 0 | 11 |
| NT5C2 | FCHO2 | 0.812596 | 7 | 0 | 7 |
| NT5C2 | SLC16A6 | 0.810219 | 11 | 0 | 11 |
| NT5C2 | CEACAM7 | 0.808784 | 10 | 0 | 10 |
| NT5C2 | RANBP9 | 0.808761 | 12 | 0 | 11 |
| NT5C2 | NMU | 0.807908 | 11 | 0 | 11 |
| NT5C2 | CHP1 | 0.807386 | 10 | 0 | 10 |
| NT5C2 | ATP13A4 | 0.807149 | 7 | 0 | 7 |
| NT5C2 | RAET1E | 0.806207 | 6 | 0 | 6 |
| NT5C2 | RBM47 | 0.805869 | 11 | 0 | 11 |
For details and further investigation, click here
