| Full name: potassium voltage-gated channel subfamily A member 2 | Alias Symbol: Kv1.2|HK4 | ||
| Type: protein-coding gene | Cytoband: 1p13.3 | ||
| Entrez ID: 3737 | HGNC ID: HGNC:6220 | Ensembl Gene: ENSG00000177301 | OMIM ID: 176262 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNA2 | 3737 | 208564_at | -0.1303 | 0.5733 | |
| GSE20347 | KCNA2 | 3737 | 208564_at | 0.0019 | 0.9833 | |
| GSE23400 | KCNA2 | 3737 | 208564_at | -0.0282 | 0.5554 | |
| GSE26886 | KCNA2 | 3737 | 208564_at | 0.0504 | 0.7876 | |
| GSE29001 | KCNA2 | 3737 | 208564_at | -0.2229 | 0.0698 | |
| GSE38129 | KCNA2 | 3737 | 208564_at | -0.0649 | 0.4662 | |
| GSE45670 | KCNA2 | 3737 | 208564_at | 0.1007 | 0.3043 | |
| GSE53622 | KCNA2 | 3737 | 119741 | -1.5274 | 0.0000 | |
| GSE53624 | KCNA2 | 3737 | 108271 | -1.9970 | 0.0000 | |
| GSE63941 | KCNA2 | 3737 | 208564_at | 0.1372 | 0.3376 | |
| GSE77861 | KCNA2 | 3737 | 208564_at | 0.0020 | 0.9913 | |
| GSE97050 | KCNA2 | 3737 | A_33_P3239282 | -0.5947 | 0.2992 | |
| SRP133303 | KCNA2 | 3737 | RNAseq | -0.6582 | 0.0033 | |
| SRP159526 | KCNA2 | 3737 | RNAseq | -2.0048 | 0.0002 | |
| SRP193095 | KCNA2 | 3737 | RNAseq | -0.1169 | 0.7273 | |
| SRP219564 | KCNA2 | 3737 | RNAseq | -0.7859 | 0.3615 | |
| TCGA | KCNA2 | 3737 | RNAseq | -2.0838 | 0.0089 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by KCNA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNA2 | 3737 | 0 | 11 | 19 | |
| GSE20123 | KCNA2 | 3737 | 0 | 11 | 19 | |
| GSE43470 | KCNA2 | 3737 | 0 | 8 | 35 | |
| GSE46452 | KCNA2 | 3737 | 2 | 1 | 56 | |
| GSE47630 | KCNA2 | 3737 | 9 | 5 | 26 | |
| GSE54993 | KCNA2 | 3737 | 0 | 1 | 69 | |
| GSE54994 | KCNA2 | 3737 | 7 | 4 | 42 | |
| GSE60625 | KCNA2 | 3737 | 0 | 0 | 11 | |
| GSE74703 | KCNA2 | 3737 | 0 | 7 | 29 | |
| GSE74704 | KCNA2 | 3737 | 0 | 7 | 13 | |
| TCGA | KCNA2 | 3737 | 8 | 27 | 61 |
Total number of gains: 26; Total number of losses: 82; Total Number of normals: 380.
Somatic mutations of KCNA2:
Generating mutation plots.
Highly correlated genes for KCNA2:
Showing top 20/669 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNA2 | GPRASP2 | 0.742465 | 3 | 0 | 3 |
| KCNA2 | MOXD1 | 0.73262 | 3 | 0 | 3 |
| KCNA2 | RGS5 | 0.723081 | 4 | 0 | 4 |
| KCNA2 | ING1 | 0.716384 | 3 | 0 | 3 |
| KCNA2 | LIFR | 0.71576 | 4 | 0 | 4 |
| KCNA2 | THAP8 | 0.713734 | 4 | 0 | 3 |
| KCNA2 | SLAIN1 | 0.711744 | 3 | 0 | 3 |
| KCNA2 | MYADM | 0.709207 | 3 | 0 | 3 |
| KCNA2 | AFF3 | 0.708782 | 4 | 0 | 4 |
| KCNA2 | AKR1E2 | 0.705684 | 3 | 0 | 3 |
| KCNA2 | TPPP | 0.705278 | 4 | 0 | 4 |
| KCNA2 | EIF4E3 | 0.700957 | 4 | 0 | 4 |
| KCNA2 | BEX5 | 0.695507 | 3 | 0 | 3 |
| KCNA2 | DNAH11 | 0.693981 | 3 | 0 | 3 |
| KCNA2 | RNF214 | 0.688977 | 4 | 0 | 3 |
| KCNA2 | C9orf47 | 0.688817 | 4 | 0 | 3 |
| KCNA2 | FAM13C | 0.68789 | 4 | 0 | 4 |
| KCNA2 | CNTD1 | 0.682735 | 3 | 0 | 3 |
| KCNA2 | OR1A1 | 0.680964 | 5 | 0 | 5 |
| KCNA2 | PCM1 | 0.680262 | 3 | 0 | 3 |
For details and further investigation, click here
