| Full name: tubulin polymerization promoting protein | Alias Symbol: p25alpha|TPPP1|p25|TPPP/p25 | ||
| Type: protein-coding gene | Cytoband: 5p15.33 | ||
| Entrez ID: 11076 | HGNC ID: HGNC:24164 | Ensembl Gene: ENSG00000171368 | OMIM ID: 608773 |
| Drug and gene relationship at DGIdb | |||
Expression of TPPP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPPP | 11076 | 230104_s_at | -1.2240 | 0.0691 | |
| GSE20347 | TPPP | 11076 | 206179_s_at | -0.1436 | 0.1649 | |
| GSE23400 | TPPP | 11076 | 206179_s_at | -0.2484 | 0.0001 | |
| GSE26886 | TPPP | 11076 | 230104_s_at | 0.0596 | 0.8557 | |
| GSE29001 | TPPP | 11076 | 206179_s_at | -0.2349 | 0.1219 | |
| GSE38129 | TPPP | 11076 | 206179_s_at | -0.3263 | 0.0194 | |
| GSE45670 | TPPP | 11076 | 230104_s_at | -0.2221 | 0.5733 | |
| GSE53622 | TPPP | 11076 | 31900 | -1.3106 | 0.0000 | |
| GSE53624 | TPPP | 11076 | 31900 | -1.3549 | 0.0000 | |
| GSE63941 | TPPP | 11076 | 230104_s_at | 0.3921 | 0.2951 | |
| GSE77861 | TPPP | 11076 | 206179_s_at | -0.0463 | 0.7154 | |
| GSE97050 | TPPP | 11076 | A_33_P3371999 | -0.7983 | 0.2151 | |
| SRP007169 | TPPP | 11076 | RNAseq | 0.2615 | 0.7080 | |
| SRP064894 | TPPP | 11076 | RNAseq | -1.3728 | 0.0003 | |
| SRP133303 | TPPP | 11076 | RNAseq | -1.2782 | 0.0000 | |
| SRP159526 | TPPP | 11076 | RNAseq | -0.7939 | 0.1670 | |
| SRP193095 | TPPP | 11076 | RNAseq | 0.2259 | 0.2866 | |
| SRP219564 | TPPP | 11076 | RNAseq | -0.2053 | 0.7755 | |
| TCGA | TPPP | 11076 | RNAseq | -0.4523 | 0.0024 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by TPPP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TPPP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPPP | 11076 | 13 | 1 | 16 | |
| GSE20123 | TPPP | 11076 | 13 | 1 | 16 | |
| GSE43470 | TPPP | 11076 | 17 | 0 | 26 | |
| GSE46452 | TPPP | 11076 | 6 | 22 | 31 | |
| GSE47630 | TPPP | 11076 | 11 | 9 | 20 | |
| GSE54993 | TPPP | 11076 | 5 | 7 | 58 | |
| GSE54994 | TPPP | 11076 | 29 | 1 | 23 | |
| GSE60625 | TPPP | 11076 | 0 | 0 | 11 | |
| GSE74703 | TPPP | 11076 | 14 | 0 | 22 | |
| GSE74704 | TPPP | 11076 | 11 | 0 | 9 | |
| TCGA | TPPP | 11076 | 60 | 4 | 32 |
Total number of gains: 179; Total number of losses: 45; Total Number of normals: 264.
Somatic mutations of TPPP:
Generating mutation plots.
Highly correlated genes for TPPP:
Showing top 20/585 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPPP | APIP | 0.769506 | 3 | 0 | 3 |
| TPPP | KLHL15 | 0.760908 | 3 | 0 | 3 |
| TPPP | CCDC136 | 0.749032 | 3 | 0 | 3 |
| TPPP | NFIA | 0.745808 | 4 | 0 | 4 |
| TPPP | CYP4V2 | 0.739077 | 3 | 0 | 3 |
| TPPP | CCDC30 | 0.738615 | 3 | 0 | 3 |
| TPPP | SLC2A12 | 0.737322 | 3 | 0 | 3 |
| TPPP | ZNF383 | 0.735966 | 3 | 0 | 3 |
| TPPP | ISOC1 | 0.734964 | 3 | 0 | 3 |
| TPPP | EDA2R | 0.734503 | 3 | 0 | 3 |
| TPPP | PLCL1 | 0.733339 | 3 | 0 | 3 |
| TPPP | EIF4E3 | 0.731805 | 4 | 0 | 3 |
| TPPP | KIF5C | 0.725461 | 3 | 0 | 3 |
| TPPP | SLMAP | 0.7215 | 4 | 0 | 4 |
| TPPP | JAM2 | 0.719679 | 3 | 0 | 3 |
| TPPP | FOXP4 | 0.715827 | 3 | 0 | 3 |
| TPPP | MAMDC2 | 0.715411 | 4 | 0 | 3 |
| TPPP | GATA1 | 0.712445 | 3 | 0 | 3 |
| TPPP | CLEC3B | 0.710274 | 3 | 0 | 3 |
| TPPP | MRPL41 | 0.709854 | 3 | 0 | 3 |
For details and further investigation, click here
