| Full name: regulator of G protein signaling 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 8490 | HGNC ID: HGNC:10001 | Ensembl Gene: ENSG00000143248 | OMIM ID: 603276 |
| Drug and gene relationship at DGIdb | |||
Expression of RGS5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RGS5 | 8490 | 209071_s_at | -0.6774 | 0.3729 | |
| GSE20347 | RGS5 | 8490 | 209071_s_at | -0.7061 | 0.0143 | |
| GSE23400 | RGS5 | 8490 | 209071_s_at | -0.8052 | 0.0001 | |
| GSE26886 | RGS5 | 8490 | 209071_s_at | -1.7193 | 0.0001 | |
| GSE29001 | RGS5 | 8490 | 209071_s_at | -1.6459 | 0.0025 | |
| GSE38129 | RGS5 | 8490 | 209071_s_at | -1.2468 | 0.0000 | |
| GSE45670 | RGS5 | 8490 | 209071_s_at | -1.5495 | 0.0002 | |
| GSE53622 | RGS5 | 8490 | 3095 | -1.3260 | 0.0000 | |
| GSE53624 | RGS5 | 8490 | 3095 | -1.4332 | 0.0000 | |
| GSE63941 | RGS5 | 8490 | 209070_s_at | -0.9220 | 0.1010 | |
| GSE77861 | RGS5 | 8490 | 209071_s_at | 1.1222 | 0.0347 | |
| GSE97050 | RGS5 | 8490 | A_33_P3243093 | -1.4022 | 0.1095 | |
| SRP007169 | RGS5 | 8490 | RNAseq | 0.4557 | 0.2808 | |
| SRP008496 | RGS5 | 8490 | RNAseq | 0.7799 | 0.0134 | |
| SRP064894 | RGS5 | 8490 | RNAseq | -0.5088 | 0.1023 | |
| SRP133303 | RGS5 | 8490 | RNAseq | -0.9937 | 0.0000 | |
| SRP159526 | RGS5 | 8490 | RNAseq | -0.1938 | 0.6381 | |
| SRP193095 | RGS5 | 8490 | RNAseq | 0.1960 | 0.5594 | |
| TCGA | RGS5 | 8490 | RNAseq | -0.6637 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 6.
Survival by RGS5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RGS5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RGS5 | 8490 | 10 | 0 | 20 | |
| GSE20123 | RGS5 | 8490 | 10 | 0 | 20 | |
| GSE43470 | RGS5 | 8490 | 7 | 2 | 34 | |
| GSE46452 | RGS5 | 8490 | 2 | 1 | 56 | |
| GSE47630 | RGS5 | 8490 | 14 | 0 | 26 | |
| GSE54993 | RGS5 | 8490 | 0 | 5 | 65 | |
| GSE54994 | RGS5 | 8490 | 16 | 0 | 37 | |
| GSE60625 | RGS5 | 8490 | 0 | 0 | 11 | |
| GSE74703 | RGS5 | 8490 | 7 | 2 | 27 | |
| GSE74704 | RGS5 | 8490 | 4 | 0 | 16 | |
| TCGA | RGS5 | 8490 | 42 | 3 | 51 |
Total number of gains: 112; Total number of losses: 13; Total Number of normals: 363.
Somatic mutations of RGS5:
Generating mutation plots.
Highly correlated genes for RGS5:
Showing top 20/794 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RGS5 | CLEC3B | 0.844768 | 3 | 0 | 3 |
| RGS5 | CYP21A2 | 0.813032 | 3 | 0 | 3 |
| RGS5 | MRVI1 | 0.81131 | 6 | 0 | 6 |
| RGS5 | FIBIN | 0.800985 | 3 | 0 | 3 |
| RGS5 | MAGI2-AS3 | 0.791507 | 4 | 0 | 4 |
| RGS5 | SORCS1 | 0.786589 | 4 | 0 | 4 |
| RGS5 | XKR4 | 0.784567 | 5 | 0 | 5 |
| RGS5 | NR2F1 | 0.783906 | 3 | 0 | 3 |
| RGS5 | ANO5 | 0.781484 | 5 | 0 | 5 |
| RGS5 | NEGR1 | 0.778157 | 5 | 0 | 5 |
| RGS5 | FOXF1 | 0.773068 | 11 | 0 | 11 |
| RGS5 | C20orf194 | 0.768378 | 3 | 0 | 3 |
| RGS5 | ANGPTL1 | 0.765595 | 5 | 0 | 5 |
| RGS5 | PLN | 0.765108 | 10 | 0 | 10 |
| RGS5 | AQP1 | 0.76482 | 12 | 0 | 12 |
| RGS5 | PPP1R12B | 0.761392 | 10 | 0 | 9 |
| RGS5 | AOC3 | 0.759711 | 10 | 0 | 10 |
| RGS5 | C3orf70 | 0.758423 | 6 | 0 | 6 |
| RGS5 | FHL1 | 0.758328 | 10 | 0 | 9 |
| RGS5 | GPRASP1 | 0.748161 | 10 | 0 | 10 |
For details and further investigation, click here
