| Full name: pericentriolar material 1 | Alias Symbol: PTC4 | ||
| Type: protein-coding gene | Cytoband: 8p22 | ||
| Entrez ID: 5108 | HGNC ID: HGNC:8727 | Ensembl Gene: ENSG00000078674 | OMIM ID: 600299 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PCM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCM1 | 5108 | 202174_s_at | -0.3544 | 0.1958 | |
| GSE20347 | PCM1 | 5108 | 202174_s_at | -0.3090 | 0.0820 | |
| GSE23400 | PCM1 | 5108 | 214118_x_at | -0.0900 | 0.0901 | |
| GSE26886 | PCM1 | 5108 | 214937_x_at | -0.2121 | 0.2884 | |
| GSE29001 | PCM1 | 5108 | 214118_x_at | -0.2855 | 0.0765 | |
| GSE38129 | PCM1 | 5108 | 202174_s_at | -0.4670 | 0.0009 | |
| GSE45670 | PCM1 | 5108 | 202174_s_at | -0.4078 | 0.0029 | |
| GSE53622 | PCM1 | 5108 | 129248 | -0.5107 | 0.0000 | |
| GSE53624 | PCM1 | 5108 | 129248 | -0.5849 | 0.0000 | |
| GSE63941 | PCM1 | 5108 | 202174_s_at | -0.6614 | 0.2222 | |
| GSE77861 | PCM1 | 5108 | 202174_s_at | 0.0549 | 0.8609 | |
| GSE97050 | PCM1 | 5108 | A_23_P82950 | -0.3140 | 0.2672 | |
| SRP007169 | PCM1 | 5108 | RNAseq | 0.4684 | 0.3087 | |
| SRP008496 | PCM1 | 5108 | RNAseq | 0.3375 | 0.3286 | |
| SRP064894 | PCM1 | 5108 | RNAseq | -0.4193 | 0.0124 | |
| SRP133303 | PCM1 | 5108 | RNAseq | -0.5437 | 0.0070 | |
| SRP159526 | PCM1 | 5108 | RNAseq | -0.4693 | 0.0515 | |
| SRP193095 | PCM1 | 5108 | RNAseq | -0.5192 | 0.0000 | |
| SRP219564 | PCM1 | 5108 | RNAseq | -0.4836 | 0.0661 | |
| TCGA | PCM1 | 5108 | RNAseq | -0.1912 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PCM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCM1 | 5108 | 3 | 10 | 17 | |
| GSE20123 | PCM1 | 5108 | 4 | 10 | 16 | |
| GSE43470 | PCM1 | 5108 | 4 | 8 | 31 | |
| GSE46452 | PCM1 | 5108 | 14 | 13 | 32 | |
| GSE47630 | PCM1 | 5108 | 10 | 8 | 22 | |
| GSE54993 | PCM1 | 5108 | 2 | 14 | 54 | |
| GSE54994 | PCM1 | 5108 | 8 | 18 | 27 | |
| GSE60625 | PCM1 | 5108 | 3 | 0 | 8 | |
| GSE74703 | PCM1 | 5108 | 4 | 7 | 25 | |
| GSE74704 | PCM1 | 5108 | 3 | 7 | 10 | |
| TCGA | PCM1 | 5108 | 14 | 41 | 41 |
Total number of gains: 69; Total number of losses: 136; Total Number of normals: 283.
Somatic mutations of PCM1:
Generating mutation plots.
Highly correlated genes for PCM1:
Showing top 20/466 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCM1 | NEK7 | 0.784035 | 3 | 0 | 3 |
| PCM1 | USP24 | 0.749035 | 3 | 0 | 3 |
| PCM1 | CSNK1A1 | 0.720405 | 3 | 0 | 3 |
| PCM1 | C9orf85 | 0.7104 | 3 | 0 | 3 |
| PCM1 | RBM8A | 0.709269 | 3 | 0 | 3 |
| PCM1 | PPP1R21 | 0.708859 | 3 | 0 | 3 |
| PCM1 | UBE2B | 0.707774 | 4 | 0 | 3 |
| PCM1 | GPBP1 | 0.698283 | 3 | 0 | 3 |
| PCM1 | SPTY2D1 | 0.69461 | 3 | 0 | 3 |
| PCM1 | UBR3 | 0.694302 | 4 | 0 | 3 |
| PCM1 | FNIP1 | 0.693772 | 4 | 0 | 4 |
| PCM1 | DHRS7 | 0.690245 | 3 | 0 | 3 |
| PCM1 | PHKB | 0.689265 | 3 | 0 | 3 |
| PCM1 | UBQLN1 | 0.687608 | 3 | 0 | 3 |
| PCM1 | KCNA2 | 0.680262 | 3 | 0 | 3 |
| PCM1 | PTAR1 | 0.671335 | 4 | 0 | 3 |
| PCM1 | HOOK3 | 0.670108 | 7 | 0 | 6 |
| PCM1 | SLC22A15 | 0.667264 | 3 | 0 | 3 |
| PCM1 | TMEM106B | 0.659812 | 4 | 0 | 4 |
| PCM1 | VPS37A | 0.651366 | 8 | 0 | 8 |
For details and further investigation, click here
