| Full name: serine/threonine kinase 16 | Alias Symbol: PKL12|MPSK | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 8576 | HGNC ID: HGNC:11394 | Ensembl Gene: ENSG00000115661 | OMIM ID: 604719 |
| Drug and gene relationship at DGIdb | |||
Expression of STK16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STK16 | 8576 | 209622_at | -0.0654 | 0.9177 | |
| GSE20347 | STK16 | 8576 | 209622_at | -0.2114 | 0.0327 | |
| GSE23400 | STK16 | 8576 | 209622_at | -0.0585 | 0.2155 | |
| GSE26886 | STK16 | 8576 | 238572_at | -0.0202 | 0.9139 | |
| GSE29001 | STK16 | 8576 | 209622_at | -0.0955 | 0.5542 | |
| GSE38129 | STK16 | 8576 | 209622_at | -0.2352 | 0.1587 | |
| GSE45670 | STK16 | 8576 | 209622_at | -0.1425 | 0.2698 | |
| GSE63941 | STK16 | 8576 | 209622_at | 0.3820 | 0.2500 | |
| GSE77861 | STK16 | 8576 | 209622_at | 0.0189 | 0.9274 | |
| GSE97050 | STK16 | 8576 | A_23_P108514 | 0.0236 | 0.9243 | |
| SRP007169 | STK16 | 8576 | RNAseq | -0.2924 | 0.6604 | |
| SRP064894 | STK16 | 8576 | RNAseq | -0.1480 | 0.4783 | |
| SRP133303 | STK16 | 8576 | RNAseq | -0.1044 | 0.4279 | |
| SRP159526 | STK16 | 8576 | RNAseq | -0.3170 | 0.1398 | |
| SRP193095 | STK16 | 8576 | RNAseq | -0.5456 | 0.0000 | |
| SRP219564 | STK16 | 8576 | RNAseq | -0.4807 | 0.1637 | |
| TCGA | STK16 | 8576 | RNAseq | -0.1586 | 0.0057 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by STK16 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of STK16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STK16 | 8576 | 2 | 14 | 14 | |
| GSE20123 | STK16 | 8576 | 2 | 13 | 15 | |
| GSE43470 | STK16 | 8576 | 1 | 7 | 35 | |
| GSE46452 | STK16 | 8576 | 0 | 5 | 54 | |
| GSE47630 | STK16 | 8576 | 4 | 5 | 31 | |
| GSE54993 | STK16 | 8576 | 1 | 2 | 67 | |
| GSE54994 | STK16 | 8576 | 8 | 9 | 36 | |
| GSE60625 | STK16 | 8576 | 0 | 3 | 8 | |
| GSE74703 | STK16 | 8576 | 1 | 5 | 30 | |
| GSE74704 | STK16 | 8576 | 2 | 7 | 11 | |
| TCGA | STK16 | 8576 | 12 | 26 | 58 |
Total number of gains: 33; Total number of losses: 96; Total Number of normals: 359.
Somatic mutations of STK16:
Generating mutation plots.
Highly correlated genes for STK16:
Showing top 20/25 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STK16 | JMJD8 | 0.817541 | 3 | 0 | 3 |
| STK16 | CLN3 | 0.787462 | 3 | 0 | 3 |
| STK16 | SLC6A3 | 0.76856 | 3 | 0 | 3 |
| STK16 | FBXL15 | 0.745661 | 3 | 0 | 3 |
| STK16 | LRIT1 | 0.700229 | 4 | 0 | 4 |
| STK16 | DHRS7B | 0.685898 | 3 | 0 | 3 |
| STK16 | RNF215 | 0.676392 | 4 | 0 | 3 |
| STK16 | KCNJ11 | 0.665807 | 3 | 0 | 3 |
| STK16 | COX8A | 0.661756 | 4 | 0 | 4 |
| STK16 | HIRIP3 | 0.65452 | 3 | 0 | 3 |
| STK16 | PGLYRP1 | 0.640468 | 3 | 0 | 3 |
| STK16 | ODF3L2 | 0.638496 | 3 | 0 | 3 |
| STK16 | NTHL1 | 0.587399 | 5 | 0 | 3 |
| STK16 | GIGYF2 | 0.586237 | 4 | 0 | 3 |
| STK16 | CPA2 | 0.585796 | 3 | 0 | 3 |
| STK16 | CD1A | 0.566433 | 4 | 0 | 3 |
| STK16 | AGR2 | 0.565879 | 3 | 0 | 3 |
| STK16 | ADH6 | 0.5657 | 4 | 0 | 3 |
| STK16 | CCL17 | 0.555899 | 6 | 0 | 3 |
| STK16 | DEFB124 | 0.555039 | 4 | 0 | 3 |
For details and further investigation, click here
