| Full name: potassium two pore domain channel subfamily K member 1 | Alias Symbol: K2p1.1|DPK|TWIK-1 | ||
| Type: protein-coding gene | Cytoband: 1q42.2 | ||
| Entrez ID: 3775 | HGNC ID: HGNC:6272 | Ensembl Gene: ENSG00000135750 | OMIM ID: 601745 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNK1 | 3775 | 204679_at | 0.4111 | 0.7783 | |
| GSE20347 | KCNK1 | 3775 | 204679_at | 0.0453 | 0.8760 | |
| GSE23400 | KCNK1 | 3775 | 204679_at | 0.1014 | 0.5727 | |
| GSE26886 | KCNK1 | 3775 | 204679_at | 0.8399 | 0.0011 | |
| GSE29001 | KCNK1 | 3775 | 204679_at | -0.1693 | 0.8107 | |
| GSE38129 | KCNK1 | 3775 | 204679_at | 0.6056 | 0.0780 | |
| GSE45670 | KCNK1 | 3775 | 204679_at | 0.6876 | 0.0118 | |
| GSE53622 | KCNK1 | 3775 | 35037 | 0.1646 | 0.4575 | |
| GSE53624 | KCNK1 | 3775 | 35037 | -0.0070 | 0.9567 | |
| GSE63941 | KCNK1 | 3775 | 204679_at | 1.9264 | 0.0010 | |
| GSE77861 | KCNK1 | 3775 | 204679_at | 0.8673 | 0.0014 | |
| GSE97050 | KCNK1 | 3775 | A_23_P126075 | 0.7553 | 0.3223 | |
| SRP007169 | KCNK1 | 3775 | RNAseq | -0.2225 | 0.6173 | |
| SRP008496 | KCNK1 | 3775 | RNAseq | -0.2180 | 0.5819 | |
| SRP064894 | KCNK1 | 3775 | RNAseq | -0.1021 | 0.7941 | |
| SRP133303 | KCNK1 | 3775 | RNAseq | 0.6333 | 0.0400 | |
| SRP159526 | KCNK1 | 3775 | RNAseq | -0.1140 | 0.8418 | |
| SRP193095 | KCNK1 | 3775 | RNAseq | -0.4105 | 0.0273 | |
| SRP219564 | KCNK1 | 3775 | RNAseq | 0.0120 | 0.9898 | |
| TCGA | KCNK1 | 3775 | RNAseq | 0.1139 | 0.4041 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by KCNK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNK1 | 3775 | 12 | 0 | 18 | |
| GSE20123 | KCNK1 | 3775 | 12 | 0 | 18 | |
| GSE43470 | KCNK1 | 3775 | 9 | 0 | 34 | |
| GSE46452 | KCNK1 | 3775 | 4 | 2 | 53 | |
| GSE47630 | KCNK1 | 3775 | 15 | 0 | 25 | |
| GSE54993 | KCNK1 | 3775 | 0 | 6 | 64 | |
| GSE54994 | KCNK1 | 3775 | 16 | 0 | 37 | |
| GSE60625 | KCNK1 | 3775 | 0 | 0 | 11 | |
| GSE74703 | KCNK1 | 3775 | 9 | 0 | 27 | |
| GSE74704 | KCNK1 | 3775 | 6 | 0 | 14 | |
| TCGA | KCNK1 | 3775 | 44 | 3 | 49 |
Total number of gains: 127; Total number of losses: 11; Total Number of normals: 350.
Somatic mutations of KCNK1:
Generating mutation plots.
Highly correlated genes for KCNK1:
Showing top 20/534 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNK1 | SESN3 | 0.712643 | 3 | 0 | 3 |
| KCNK1 | MORC2 | 0.709964 | 3 | 0 | 3 |
| KCNK1 | CKS1B | 0.698468 | 4 | 0 | 4 |
| KCNK1 | GRHL2 | 0.698285 | 5 | 0 | 4 |
| KCNK1 | BLACAT1 | 0.697572 | 5 | 0 | 4 |
| KCNK1 | FBRSL1 | 0.692519 | 3 | 0 | 3 |
| KCNK1 | NMT1 | 0.691888 | 5 | 0 | 5 |
| KCNK1 | LONP1 | 0.689306 | 3 | 0 | 3 |
| KCNK1 | TENM2 | 0.689278 | 5 | 0 | 4 |
| KCNK1 | CCT3 | 0.680237 | 3 | 0 | 3 |
| KCNK1 | E2F6 | 0.677858 | 3 | 0 | 3 |
| KCNK1 | F11R | 0.674147 | 8 | 0 | 8 |
| KCNK1 | C14orf119 | 0.674131 | 3 | 0 | 3 |
| KCNK1 | SLC37A2 | 0.674125 | 4 | 0 | 4 |
| KCNK1 | FERMT1 | 0.674121 | 10 | 0 | 8 |
| KCNK1 | MB21D2 | 0.673815 | 4 | 0 | 3 |
| KCNK1 | CDCA7L | 0.668845 | 3 | 0 | 3 |
| KCNK1 | PPP1R14C | 0.668579 | 6 | 0 | 5 |
| KCNK1 | UAP1L1 | 0.662084 | 4 | 0 | 4 |
| KCNK1 | DLX6-AS1 | 0.661761 | 5 | 0 | 4 |
For details and further investigation, click here
