| Full name: grainyhead like transcription factor 2 | Alias Symbol: FLJ13782|BOM | ||
| Type: protein-coding gene | Cytoband: 8q22.3 | ||
| Entrez ID: 79977 | HGNC ID: HGNC:2799 | Ensembl Gene: ENSG00000083307 | OMIM ID: 608576 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of GRHL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRHL2 | 79977 | 219388_at | 0.6740 | 0.4402 | |
| GSE20347 | GRHL2 | 79977 | 219388_at | -0.0521 | 0.7850 | |
| GSE23400 | GRHL2 | 79977 | 219388_at | 0.1756 | 0.0952 | |
| GSE26886 | GRHL2 | 79977 | 219388_at | -0.1438 | 0.5592 | |
| GSE29001 | GRHL2 | 79977 | 219388_at | -0.0900 | 0.7642 | |
| GSE38129 | GRHL2 | 79977 | 219388_at | 0.4213 | 0.2806 | |
| GSE45670 | GRHL2 | 79977 | 219388_at | 0.4824 | 0.0707 | |
| GSE53622 | GRHL2 | 79977 | 3186 | 0.3384 | 0.0869 | |
| GSE53624 | GRHL2 | 79977 | 3186 | -0.0376 | 0.7031 | |
| GSE63941 | GRHL2 | 79977 | 219388_at | 4.6308 | 0.0003 | |
| GSE77861 | GRHL2 | 79977 | 219388_at | -0.2481 | 0.4421 | |
| GSE97050 | GRHL2 | 79977 | A_33_P3321642 | 1.2509 | 0.2557 | |
| SRP007169 | GRHL2 | 79977 | RNAseq | -0.3194 | 0.4715 | |
| SRP008496 | GRHL2 | 79977 | RNAseq | -0.3458 | 0.1216 | |
| SRP064894 | GRHL2 | 79977 | RNAseq | -0.1060 | 0.8088 | |
| SRP133303 | GRHL2 | 79977 | RNAseq | -0.3088 | 0.1980 | |
| SRP159526 | GRHL2 | 79977 | RNAseq | -0.2261 | 0.3162 | |
| SRP193095 | GRHL2 | 79977 | RNAseq | -0.3243 | 0.0361 | |
| SRP219564 | GRHL2 | 79977 | RNAseq | 0.1725 | 0.8683 | |
| TCGA | GRHL2 | 79977 | RNAseq | 0.3906 | 0.0129 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GRHL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRHL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRHL2 | 79977 | 17 | 0 | 13 | |
| GSE20123 | GRHL2 | 79977 | 17 | 0 | 13 | |
| GSE43470 | GRHL2 | 79977 | 22 | 0 | 21 | |
| GSE46452 | GRHL2 | 79977 | 24 | 0 | 35 | |
| GSE47630 | GRHL2 | 79977 | 24 | 0 | 16 | |
| GSE54993 | GRHL2 | 79977 | 0 | 20 | 50 | |
| GSE54994 | GRHL2 | 79977 | 38 | 1 | 14 | |
| GSE60625 | GRHL2 | 79977 | 0 | 4 | 7 | |
| GSE74703 | GRHL2 | 79977 | 19 | 0 | 17 | |
| GSE74704 | GRHL2 | 79977 | 12 | 0 | 8 | |
| TCGA | GRHL2 | 79977 | 57 | 3 | 36 |
Total number of gains: 230; Total number of losses: 28; Total Number of normals: 230.
Somatic mutations of GRHL2:
Generating mutation plots.
Highly correlated genes for GRHL2:
Showing top 20/394 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRHL2 | BAZ2A | 0.756669 | 3 | 0 | 3 |
| GRHL2 | ST14 | 0.756025 | 6 | 0 | 5 |
| GRHL2 | LAD1 | 0.745783 | 6 | 0 | 5 |
| GRHL2 | FCF1 | 0.743369 | 3 | 0 | 3 |
| GRHL2 | GJB5 | 0.736878 | 5 | 0 | 5 |
| GRHL2 | DSC2 | 0.729867 | 4 | 0 | 4 |
| GRHL2 | MACC1 | 0.72927 | 3 | 0 | 3 |
| GRHL2 | DICER1 | 0.727663 | 3 | 0 | 3 |
| GRHL2 | DMKN | 0.727439 | 3 | 0 | 3 |
| GRHL2 | KDF1 | 0.725986 | 5 | 0 | 5 |
| GRHL2 | AP1S3 | 0.722623 | 4 | 0 | 4 |
| GRHL2 | FAM160A1 | 0.719984 | 3 | 0 | 3 |
| GRHL2 | GSTP1 | 0.719463 | 4 | 0 | 4 |
| GRHL2 | CYB5R2 | 0.715324 | 3 | 0 | 3 |
| GRHL2 | SLC29A2 | 0.707466 | 3 | 0 | 3 |
| GRHL2 | ARRDC1 | 0.706364 | 5 | 0 | 4 |
| GRHL2 | TFAP2A | 0.705562 | 6 | 0 | 5 |
| GRHL2 | ULBP2 | 0.704989 | 3 | 0 | 3 |
| GRHL2 | TSTA3 | 0.699809 | 5 | 0 | 5 |
| GRHL2 | PAK6 | 0.699223 | 3 | 0 | 3 |
For details and further investigation, click here
