E2F6

 

Full name: E2F transcription factor 6 Alias Symbol: E2F-6
Type: protein-coding gene Cytoband: 2p25.1
Entrez ID: 1876 HGNC ID: HGNC:3120 Ensembl Gene: ENSG00000169016 OMIM ID: 602944
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of E2F6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 E2F6 1876 203957_at 0.9237 0.0086
GSE20347 E2F6 1876 203957_at 1.0068 0.0000
GSE23400 E2F6 1876 203957_at 0.6100 0.0000
GSE26886 E2F6 1876 203957_at 0.8786 0.0000
GSE29001 E2F6 1876 203957_at 1.0177 0.0039
GSE38129 E2F6 1876 203957_at 0.9985 0.0000
GSE45670 E2F6 1876 203957_at 0.7509 0.0002
GSE53622 E2F6 1876 110950 0.8480 0.0000
GSE53624 E2F6 1876 110950 1.0460 0.0000
GSE63941 E2F6 1876 203957_at 0.2749 0.5644
GSE77861 E2F6 1876 203957_at 0.7802 0.0022
GSE97050 E2F6 1876 A_33_P3416301 0.2287 0.3673
SRP007169 E2F6 1876 RNAseq 2.0865 0.0000
SRP008496 E2F6 1876 RNAseq 1.9667 0.0000
SRP064894 E2F6 1876 RNAseq 0.5312 0.0004
SRP133303 E2F6 1876 RNAseq 0.8928 0.0000
SRP159526 E2F6 1876 RNAseq 1.3095 0.0011
SRP193095 E2F6 1876 RNAseq 0.8036 0.0000
SRP219564 E2F6 1876 RNAseq 0.5380 0.1824
TCGA E2F6 1876 RNAseq 0.1130 0.0611

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by E2F6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of E2F6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 E2F6 1876 10 2 18
GSE20123 E2F6 1876 10 2 18
GSE43470 E2F6 1876 2 1 40
GSE46452 E2F6 1876 3 4 52
GSE47630 E2F6 1876 7 0 33
GSE54993 E2F6 1876 0 7 63
GSE54994 E2F6 1876 11 0 42
GSE60625 E2F6 1876 0 3 8
GSE74703 E2F6 1876 2 0 34
GSE74704 E2F6 1876 9 1 10
TCGA E2F6 1876 34 5 57

Total number of gains: 88; Total number of losses: 25; Total Number of normals: 375.  

 

Somatic mutations of E2F6:

 

Generating mutation plots.

 

Highly correlated genes for E2F6:

 

Showing top 20/2217 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
E2F6ACTL6A0.78794611011
E2F6RFC40.78758611011
E2F6MCM60.7869611011
E2F6BID0.77370110010
E2F6MSH60.77124412012
E2F6DESI20.76090510010
E2F6PSME40.75853911011
E2F6RUVBL10.75778711011
E2F6C1orf1310.75617707
E2F6MCM20.75469710010
E2F6CKS1B0.75313511011
E2F6CACYBP0.75288411011
E2F6SLC41A10.751676707
E2F6TFRC0.75054211011
E2F6MTERF30.750464808
E2F6SNRPE0.75005210010
E2F6UBE2T0.749084707
E2F6CAD0.74721512012
E2F6HAS30.745294404
E2F6HLTF0.7446812011

For details and further investigation, click here