| Full name: acireductone dioxygenase 1 | Alias Symbol: SIPL|MTCBP-1|ARD|APL1|FLJ10913|HMFT1638|mtnD | ||
| Type: protein-coding gene | Cytoband: 2p25.3 | ||
| Entrez ID: 55256 | HGNC ID: HGNC:30576 | Ensembl Gene: ENSG00000182551 | OMIM ID: 613400 |
| Drug and gene relationship at DGIdb | |||
Expression of ADI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADI1 | 55256 | 222400_s_at | 0.4223 | 0.2909 | |
| GSE20347 | ADI1 | 55256 | 217761_at | 0.3048 | 0.1623 | |
| GSE23400 | ADI1 | 55256 | 217761_at | 0.2756 | 0.0120 | |
| GSE26886 | ADI1 | 55256 | 217761_at | -0.3373 | 0.1804 | |
| GSE29001 | ADI1 | 55256 | 217761_at | 0.3807 | 0.1058 | |
| GSE38129 | ADI1 | 55256 | 217761_at | 0.2511 | 0.1736 | |
| GSE45670 | ADI1 | 55256 | 222400_s_at | 0.1273 | 0.4411 | |
| GSE53622 | ADI1 | 55256 | 39007 | -0.1053 | 0.3337 | |
| GSE53624 | ADI1 | 55256 | 108762 | 0.0194 | 0.8127 | |
| GSE63941 | ADI1 | 55256 | 222400_s_at | -0.3617 | 0.4836 | |
| GSE77861 | ADI1 | 55256 | 222400_s_at | -0.0180 | 0.9399 | |
| GSE97050 | ADI1 | 55256 | A_23_P148194 | -0.2588 | 0.3398 | |
| SRP007169 | ADI1 | 55256 | RNAseq | -0.6271 | 0.1822 | |
| SRP008496 | ADI1 | 55256 | RNAseq | -0.5244 | 0.0674 | |
| SRP064894 | ADI1 | 55256 | RNAseq | -0.1831 | 0.3879 | |
| SRP133303 | ADI1 | 55256 | RNAseq | 0.1678 | 0.4384 | |
| SRP159526 | ADI1 | 55256 | RNAseq | 0.1029 | 0.7295 | |
| SRP193095 | ADI1 | 55256 | RNAseq | -0.2463 | 0.1157 | |
| SRP219564 | ADI1 | 55256 | RNAseq | -0.2057 | 0.7059 | |
| TCGA | ADI1 | 55256 | RNAseq | -0.1552 | 0.0018 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ADI1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADI1 | 55256 | 8 | 3 | 19 | |
| GSE20123 | ADI1 | 55256 | 8 | 3 | 19 | |
| GSE43470 | ADI1 | 55256 | 3 | 1 | 39 | |
| GSE46452 | ADI1 | 55256 | 3 | 4 | 52 | |
| GSE47630 | ADI1 | 55256 | 7 | 0 | 33 | |
| GSE54993 | ADI1 | 55256 | 1 | 7 | 62 | |
| GSE54994 | ADI1 | 55256 | 12 | 1 | 40 | |
| GSE60625 | ADI1 | 55256 | 0 | 3 | 8 | |
| GSE74703 | ADI1 | 55256 | 3 | 0 | 33 | |
| GSE74704 | ADI1 | 55256 | 8 | 1 | 11 | |
| TCGA | ADI1 | 55256 | 32 | 5 | 59 |
Total number of gains: 85; Total number of losses: 28; Total Number of normals: 375.
Somatic mutations of ADI1:
Generating mutation plots.
Highly correlated genes for ADI1:
Showing top 20/153 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADI1 | KHK | 0.762862 | 4 | 0 | 4 |
| ADI1 | GRB14 | 0.686475 | 3 | 0 | 3 |
| ADI1 | FAM111A | 0.678785 | 3 | 0 | 3 |
| ADI1 | NAP1L4 | 0.675536 | 4 | 0 | 4 |
| ADI1 | TXNRD1 | 0.667543 | 3 | 0 | 3 |
| ADI1 | ING3 | 0.662808 | 3 | 0 | 3 |
| ADI1 | IFRD2 | 0.659431 | 3 | 0 | 3 |
| ADI1 | RWDD2B | 0.655299 | 3 | 0 | 3 |
| ADI1 | ZBTB38 | 0.649192 | 3 | 0 | 3 |
| ADI1 | USP14 | 0.647877 | 3 | 0 | 3 |
| ADI1 | ACVR1 | 0.640603 | 3 | 0 | 3 |
| ADI1 | MEX3C | 0.636167 | 3 | 0 | 3 |
| ADI1 | LGALS8 | 0.633888 | 3 | 0 | 3 |
| ADI1 | LAMTOR1 | 0.632292 | 3 | 0 | 3 |
| ADI1 | GPD2 | 0.631461 | 3 | 0 | 3 |
| ADI1 | PAK1 | 0.630866 | 5 | 0 | 4 |
| ADI1 | PHKA1 | 0.63079 | 3 | 0 | 3 |
| ADI1 | C9orf40 | 0.625284 | 4 | 0 | 3 |
| ADI1 | SMCHD1 | 0.622586 | 3 | 0 | 3 |
| ADI1 | RTN3 | 0.622362 | 4 | 0 | 3 |
For details and further investigation, click here
