| Full name: dihydrofolate reductase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q14.1 | ||
| Entrez ID: 1719 | HGNC ID: HGNC:2861 | Ensembl Gene: ENSG00000228716 | OMIM ID: 126060 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DHFR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHFR | 1719 | 202534_x_at | 0.2510 | 0.5327 | |
| GSE20347 | DHFR | 1719 | 202534_x_at | 0.3463 | 0.0560 | |
| GSE23400 | DHFR | 1719 | 202534_x_at | 0.5964 | 0.0000 | |
| GSE26886 | DHFR | 1719 | 202534_x_at | 0.1322 | 0.6202 | |
| GSE29001 | DHFR | 1719 | 202534_x_at | 0.5135 | 0.1945 | |
| GSE38129 | DHFR | 1719 | 202534_x_at | 0.4416 | 0.0108 | |
| GSE45670 | DHFR | 1719 | 202534_x_at | 0.4431 | 0.0203 | |
| GSE53622 | DHFR | 1719 | 58684 | 0.8878 | 0.0000 | |
| GSE53624 | DHFR | 1719 | 58684 | 1.2320 | 0.0000 | |
| GSE63941 | DHFR | 1719 | 202534_x_at | -0.1716 | 0.8851 | |
| GSE77861 | DHFR | 1719 | 202534_x_at | 0.2447 | 0.6162 | |
| GSE97050 | DHFR | 1719 | A_24_P343095 | 0.6963 | 0.1496 | |
| SRP007169 | DHFR | 1719 | RNAseq | 1.7758 | 0.0002 | |
| SRP008496 | DHFR | 1719 | RNAseq | 1.2085 | 0.0012 | |
| SRP064894 | DHFR | 1719 | RNAseq | 0.5542 | 0.0131 | |
| SRP133303 | DHFR | 1719 | RNAseq | 0.6387 | 0.0023 | |
| SRP159526 | DHFR | 1719 | RNAseq | 0.5707 | 0.0476 | |
| SRP193095 | DHFR | 1719 | RNAseq | -0.0650 | 0.6601 | |
| SRP219564 | DHFR | 1719 | RNAseq | 0.1321 | 0.6700 | |
| TCGA | DHFR | 1719 | RNAseq | 0.3612 | 0.0002 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by DHFR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHFR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHFR | 1719 | 1 | 13 | 16 | |
| GSE20123 | DHFR | 1719 | 1 | 13 | 16 | |
| GSE43470 | DHFR | 1719 | 1 | 11 | 31 | |
| GSE46452 | DHFR | 1719 | 0 | 28 | 31 | |
| GSE47630 | DHFR | 1719 | 1 | 19 | 20 | |
| GSE54993 | DHFR | 1719 | 8 | 1 | 61 | |
| GSE54994 | DHFR | 1719 | 2 | 18 | 33 | |
| GSE60625 | DHFR | 1719 | 0 | 0 | 11 | |
| GSE74703 | DHFR | 1719 | 1 | 7 | 28 | |
| GSE74704 | DHFR | 1719 | 1 | 6 | 13 | |
| TCGA | DHFR | 1719 | 5 | 49 | 42 |
Total number of gains: 21; Total number of losses: 165; Total Number of normals: 302.
Somatic mutations of DHFR:
Generating mutation plots.
Highly correlated genes for DHFR:
Showing top 20/874 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHFR | MMS22L | 0.763502 | 3 | 0 | 3 |
| DHFR | CENPH | 0.753974 | 5 | 0 | 5 |
| DHFR | ANAPC1 | 0.752847 | 3 | 0 | 3 |
| DHFR | HHEX | 0.744626 | 3 | 0 | 3 |
| DHFR | KHK | 0.739369 | 3 | 0 | 3 |
| DHFR | SLC10A3 | 0.738634 | 3 | 0 | 3 |
| DHFR | PYCR2 | 0.736209 | 3 | 0 | 3 |
| DHFR | UBXN2A | 0.73202 | 3 | 0 | 3 |
| DHFR | SCNM1 | 0.717135 | 3 | 0 | 3 |
| DHFR | CAGE1 | 0.710589 | 4 | 0 | 4 |
| DHFR | C18orf54 | 0.706882 | 5 | 0 | 4 |
| DHFR | FLNB | 0.706625 | 3 | 0 | 3 |
| DHFR | USP48 | 0.706392 | 3 | 0 | 3 |
| DHFR | RRP7A | 0.703018 | 4 | 0 | 4 |
| DHFR | DZIP3 | 0.7029 | 3 | 0 | 3 |
| DHFR | SLC36A4 | 0.699036 | 3 | 0 | 3 |
| DHFR | MAP4K2 | 0.695163 | 3 | 0 | 3 |
| DHFR | SNAP47 | 0.69337 | 3 | 0 | 3 |
| DHFR | FMNL3 | 0.691003 | 3 | 0 | 3 |
| DHFR | CISD2 | 0.690509 | 4 | 0 | 3 |
For details and further investigation, click here
