KIF3A

 

Full name: kinesin family member 3A Alias Symbol: FLA10|KLP-20
Type: protein-coding gene Cytoband: 5q31.1
Entrez ID: 11127 HGNC ID: HGNC:6319 Ensembl Gene: ENSG00000131437 OMIM ID: 604683
Drug and gene relationship at DGIdb

 

KIF3A involved pathways:

KEGG pathway Description View
hsa04340Hedgehog signaling pathway

 

Expression of KIF3A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KIF3A 11127 228680_at 0.4967 0.2103
GSE20347 KIF3A 11127 213623_at 0.3903 0.0511
GSE23400 KIF3A 11127 213623_at 0.0896 0.0087
GSE26886 KIF3A 11127 228680_at 0.4741 0.0581
GSE29001 KIF3A 11127 213623_at 0.2523 0.3792
GSE38129 KIF3A 11127 213623_at 0.4384 0.0166
GSE45670 KIF3A 11127 228680_at 0.1665 0.3788
GSE53622 KIF3A 11127 32911 0.3174 0.0007
GSE53624 KIF3A 11127 32911 0.4621 0.0000
GSE63941 KIF3A 11127 228680_at -0.8334 0.1283
GSE77861 KIF3A 11127 228680_at 0.1037 0.5071
GSE97050 KIF3A 11127 A_33_P3465247 0.2268 0.5631
SRP007169 KIF3A 11127 RNAseq 0.7663 0.1639
SRP008496 KIF3A 11127 RNAseq 1.0072 0.0127
SRP064894 KIF3A 11127 RNAseq 0.2784 0.2127
SRP133303 KIF3A 11127 RNAseq 0.7209 0.0007
SRP159526 KIF3A 11127 RNAseq 0.6938 0.0297
SRP193095 KIF3A 11127 RNAseq 0.2843 0.0022
SRP219564 KIF3A 11127 RNAseq 0.0391 0.9550
TCGA KIF3A 11127 RNAseq -0.0536 0.3848

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by KIF3A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of KIF3A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KIF3A 11127 1 11 18
GSE20123 KIF3A 11127 2 11 17
GSE43470 KIF3A 11127 2 9 32
GSE46452 KIF3A 11127 0 27 32
GSE47630 KIF3A 11127 0 21 19
GSE54993 KIF3A 11127 9 1 60
GSE54994 KIF3A 11127 2 14 37
GSE60625 KIF3A 11127 0 0 11
GSE74703 KIF3A 11127 2 6 28
GSE74704 KIF3A 11127 1 5 14
TCGA KIF3A 11127 3 39 54

Total number of gains: 22; Total number of losses: 144; Total Number of normals: 322.  

 

Somatic mutations of KIF3A:

 

Generating mutation plots.

 

Highly correlated genes for KIF3A:

 

Showing top 20/554 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KIF3APET1170.801787303
KIF3AMRPL130.787986303
KIF3AZNF3970.773972303
KIF3ABDP10.772441303
KIF3AADAM190.767028303
KIF3APLEKHB20.738206303
KIF3AKANK40.738087303
KIF3AFAM98A0.735119303
KIF3AC12orf650.726454303
KIF3AZNF1210.726385303
KIF3ANAP1L10.724938303
KIF3AFOXN20.718168303
KIF3AZFP900.71304404
KIF3APOFUT10.712393505
KIF3ALMBR10.70999303
KIF3ACERCAM0.709465303
KIF3ASNRPD30.707567303
KIF3ANEIL20.706851303
KIF3AFAM160B10.700478303
KIF3AVANGL20.697012303

For details and further investigation, click here