| Full name: ADAM metallopeptidase domain 19 | Alias Symbol: MLTNB | ||
| Type: protein-coding gene | Cytoband: 5q33.3 | ||
| Entrez ID: 8728 | HGNC ID: HGNC:197 | Ensembl Gene: ENSG00000135074 | OMIM ID: 603640 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAM19:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAM19 | 8728 | 209765_at | 0.1140 | 0.8641 | |
| GSE20347 | ADAM19 | 8728 | 209765_at | -0.1162 | 0.4244 | |
| GSE23400 | ADAM19 | 8728 | 209765_at | 0.0373 | 0.6037 | |
| GSE26886 | ADAM19 | 8728 | 209765_at | -0.2113 | 0.5662 | |
| GSE29001 | ADAM19 | 8728 | 209765_at | 0.0409 | 0.9211 | |
| GSE38129 | ADAM19 | 8728 | 209765_at | -0.1124 | 0.5890 | |
| GSE45670 | ADAM19 | 8728 | 209765_at | -0.3914 | 0.1927 | |
| GSE53622 | ADAM19 | 8728 | 66216 | 0.6166 | 0.0000 | |
| GSE53624 | ADAM19 | 8728 | 69511 | 0.6703 | 0.0000 | |
| GSE63941 | ADAM19 | 8728 | 209765_at | -1.4091 | 0.1694 | |
| GSE77861 | ADAM19 | 8728 | 209765_at | 0.1781 | 0.6002 | |
| GSE97050 | ADAM19 | 8728 | A_23_P81369 | 0.7587 | 0.1239 | |
| SRP007169 | ADAM19 | 8728 | RNAseq | 1.3436 | 0.0013 | |
| SRP008496 | ADAM19 | 8728 | RNAseq | 1.4121 | 0.0000 | |
| SRP064894 | ADAM19 | 8728 | RNAseq | 0.6353 | 0.0347 | |
| SRP133303 | ADAM19 | 8728 | RNAseq | 0.8010 | 0.0014 | |
| SRP159526 | ADAM19 | 8728 | RNAseq | -0.3918 | 0.3225 | |
| SRP193095 | ADAM19 | 8728 | RNAseq | 0.8066 | 0.0003 | |
| SRP219564 | ADAM19 | 8728 | RNAseq | 0.6329 | 0.2442 | |
| TCGA | ADAM19 | 8728 | RNAseq | 0.1274 | 0.2569 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ADAM19 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAM19:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAM19 | 8728 | 0 | 11 | 19 | |
| GSE20123 | ADAM19 | 8728 | 0 | 11 | 19 | |
| GSE43470 | ADAM19 | 8728 | 2 | 11 | 30 | |
| GSE46452 | ADAM19 | 8728 | 0 | 27 | 32 | |
| GSE47630 | ADAM19 | 8728 | 0 | 20 | 20 | |
| GSE54993 | ADAM19 | 8728 | 9 | 1 | 60 | |
| GSE54994 | ADAM19 | 8728 | 1 | 16 | 36 | |
| GSE60625 | ADAM19 | 8728 | 0 | 0 | 11 | |
| GSE74703 | ADAM19 | 8728 | 2 | 8 | 26 | |
| GSE74704 | ADAM19 | 8728 | 0 | 6 | 14 | |
| TCGA | ADAM19 | 8728 | 5 | 36 | 55 |
Total number of gains: 19; Total number of losses: 147; Total Number of normals: 322.
Somatic mutations of ADAM19:
Generating mutation plots.
Highly correlated genes for ADAM19:
Showing top 20/502 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAM19 | LMO1 | 0.770502 | 3 | 0 | 3 |
| ADAM19 | KIF3A | 0.767028 | 3 | 0 | 3 |
| ADAM19 | HRH1 | 0.748698 | 3 | 0 | 3 |
| ADAM19 | RAB11FIP5 | 0.743475 | 3 | 0 | 3 |
| ADAM19 | RFTN2 | 0.725408 | 3 | 0 | 3 |
| ADAM19 | ALPK2 | 0.7242 | 3 | 0 | 3 |
| ADAM19 | ANKRD44 | 0.718098 | 3 | 0 | 3 |
| ADAM19 | TMEM65 | 0.716668 | 3 | 0 | 3 |
| ADAM19 | TCF25 | 0.712865 | 3 | 0 | 3 |
| ADAM19 | CST7 | 0.701439 | 3 | 0 | 3 |
| ADAM19 | SLC39A13 | 0.698832 | 4 | 0 | 4 |
| ADAM19 | CATSPER1 | 0.69402 | 3 | 0 | 3 |
| ADAM19 | G0S2 | 0.684462 | 4 | 0 | 3 |
| ADAM19 | AMPD3 | 0.681127 | 3 | 0 | 3 |
| ADAM19 | ANGPTL4 | 0.679346 | 4 | 0 | 3 |
| ADAM19 | LRRC8C | 0.675849 | 3 | 0 | 3 |
| ADAM19 | STAM | 0.67325 | 3 | 0 | 3 |
| ADAM19 | CEP170 | 0.669721 | 3 | 0 | 3 |
| ADAM19 | DTX1 | 0.666807 | 3 | 0 | 3 |
| ADAM19 | MKNK1 | 0.662575 | 3 | 0 | 3 |
For details and further investigation, click here
