VANGL2

 

Full name: VANGL planar cell polarity protein 2 Alias Symbol: KIAA1215|LTAP|LPP1|STBM|STB1|STBM1|MGC119403|MGC119404
Type: protein-coding gene Cytoband: 1q23.2
Entrez ID: 57216 HGNC ID: HGNC:15511 Ensembl Gene: ENSG00000162738 OMIM ID: 600533
Drug and gene relationship at DGIdb

 

VANGL2 involved pathways:

KEGG pathway Description View
hsa04310Wnt signaling pathway

 

Expression of VANGL2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 VANGL2 57216 226029_at 1.3970 0.0298
GSE26886 VANGL2 57216 226029_at -0.1827 0.6780
GSE45670 VANGL2 57216 226029_at 1.1321 0.0000
GSE53622 VANGL2 57216 30604 0.8265 0.0000
GSE53624 VANGL2 57216 30604 0.9393 0.0000
GSE63941 VANGL2 57216 226029_at 1.2200 0.2716
GSE77861 VANGL2 57216 226029_at 0.9111 0.1149
GSE97050 VANGL2 57216 A_33_P3282005 0.2262 0.3038
SRP007169 VANGL2 57216 RNAseq 0.5903 0.2150
SRP008496 VANGL2 57216 RNAseq 0.8699 0.0034
SRP064894 VANGL2 57216 RNAseq 0.6058 0.0165
SRP133303 VANGL2 57216 RNAseq 0.5604 0.0417
SRP159526 VANGL2 57216 RNAseq 1.6501 0.0000
SRP193095 VANGL2 57216 RNAseq 0.9487 0.0002
SRP219564 VANGL2 57216 RNAseq 0.0904 0.8747
TCGA VANGL2 57216 RNAseq 0.4199 0.0001

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by VANGL2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of VANGL2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 VANGL2 57216 10 0 20
GSE20123 VANGL2 57216 10 0 20
GSE43470 VANGL2 57216 7 2 34
GSE46452 VANGL2 57216 2 1 56
GSE47630 VANGL2 57216 14 0 26
GSE54993 VANGL2 57216 0 5 65
GSE54994 VANGL2 57216 16 0 37
GSE60625 VANGL2 57216 0 0 11
GSE74703 VANGL2 57216 7 2 27
GSE74704 VANGL2 57216 4 0 16
TCGA VANGL2 57216 44 3 49

Total number of gains: 114; Total number of losses: 13; Total Number of normals: 361.  

 

Somatic mutations of VANGL2:

 

Generating mutation plots.

 

Highly correlated genes for VANGL2:

 

Showing top 20/703 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
VANGL2UBQLN40.76954404
VANGL2IGF2R0.767015404
VANGL2NAPEPLD0.760388303
VANGL2ORC20.744282303
VANGL2TMPO0.743059303
VANGL2MRPS60.736779303
VANGL2POFUT10.730611303
VANGL2TYW50.730192303
VANGL2SPIRE20.730051303
VANGL2ZNF8300.728543303
VANGL2FZR10.724653303
VANGL2FAM86C10.721832303
VANGL2ZNF70.718455303
VANGL2ELAC20.71795303
VANGL2SLC46A10.709025303
VANGL2PGBD50.708284504
VANGL2TMEM132A0.707696303
VANGL2TOMM40L0.707573303
VANGL2DUSP230.705894404
VANGL2RGS190.704096303

For details and further investigation, click here