POFUT1

 

Full name: protein O-fucosyltransferase 1 Alias Symbol: O-FUT|O-Fuc-T|KIAA0180|FUT12
Type: protein-coding gene Cytoband: 20q11.21
Entrez ID: 23509 HGNC ID: HGNC:14988 Ensembl Gene: ENSG00000101346 OMIM ID: 607491
Drug and gene relationship at DGIdb

 

Expression of POFUT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POFUT1 23509 212349_at 0.8473 0.0250
GSE20347 POFUT1 23509 212349_at 0.3529 0.0001
GSE23400 POFUT1 23509 212349_at 0.1508 0.0013
GSE26886 POFUT1 23509 212349_at 0.5775 0.0028
GSE29001 POFUT1 23509 212349_at 0.6082 0.0369
GSE38129 POFUT1 23509 212349_at 0.3171 0.0007
GSE45670 POFUT1 23509 212349_at 0.1095 0.4337
GSE53622 POFUT1 23509 55794 0.6935 0.0000
GSE53624 POFUT1 23509 112565 0.8887 0.0000
GSE63941 POFUT1 23509 212349_at -0.5145 0.1538
GSE77861 POFUT1 23509 212349_at 0.1720 0.2108
GSE97050 POFUT1 23509 A_33_P3384845 0.3960 0.1623
SRP007169 POFUT1 23509 RNAseq 1.4173 0.0008
SRP008496 POFUT1 23509 RNAseq 1.3838 0.0000
SRP064894 POFUT1 23509 RNAseq 1.0853 0.0000
SRP133303 POFUT1 23509 RNAseq 0.7259 0.0000
SRP159526 POFUT1 23509 RNAseq 0.8486 0.0000
SRP193095 POFUT1 23509 RNAseq 0.9350 0.0000
SRP219564 POFUT1 23509 RNAseq 0.9590 0.0127
TCGA POFUT1 23509 RNAseq 0.1233 0.0075

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by POFUT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POFUT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POFUT1 23509 15 0 15
GSE20123 POFUT1 23509 15 0 15
GSE43470 POFUT1 23509 12 0 31
GSE46452 POFUT1 23509 29 0 30
GSE47630 POFUT1 23509 24 1 15
GSE54993 POFUT1 23509 0 18 52
GSE54994 POFUT1 23509 26 3 24
GSE60625 POFUT1 23509 0 0 11
GSE74703 POFUT1 23509 11 0 25
GSE74704 POFUT1 23509 10 0 10
TCGA POFUT1 23509 49 1 46

Total number of gains: 191; Total number of losses: 23; Total Number of normals: 274.  

 

Somatic mutations of POFUT1:

 

Generating mutation plots.

 

Highly correlated genes for POFUT1:

 

Showing top 20/765 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POFUT1CENPBD10.838945303
POFUT1ROMO10.83036303
POFUT1C2orf690.801122303
POFUT1NAPEPLD0.776864303
POFUT1CYP27C10.769104303
POFUT1NEK60.759434303
POFUT1UBQLN40.752898303
POFUT1CDKN2D0.748867303
POFUT1TMSB100.746415404
POFUT1HELB0.74058303
POFUT1CABLES20.732047303
POFUT1VANGL20.730611303
POFUT1MRPL140.72996303
POFUT1ZNF3190.726764404
POFUT1GPR1580.725174404
POFUT1CCM20.722768504
POFUT1PET1170.718401404
POFUT1KIF3A0.712393505
POFUT1MRPS260.709785404
POFUT1RNF2130.707294303

For details and further investigation, click here