SETD2

 

Full name: SET domain containing 2, histone lysine methyltransferase Alias Symbol: HYPB|HIF-1|KIAA1732|FLJ23184|KMT3A
Type: protein-coding gene Cytoband: 3p21.31
Entrez ID: 29072 HGNC ID: HGNC:18420 Ensembl Gene: ENSG00000181555 OMIM ID: 612778
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 18/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SETD2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SETD2 29072 212493_s_at -0.0969 0.7709
GSE20347 SETD2 29072 212493_s_at -0.3314 0.0009
GSE23400 SETD2 29072 212493_s_at -0.0348 0.3937
GSE26886 SETD2 29072 212493_s_at 0.5755 0.0010
GSE29001 SETD2 29072 212493_s_at -0.0470 0.8840
GSE38129 SETD2 29072 212493_s_at -0.3861 0.0002
GSE45670 SETD2 29072 212493_s_at -0.3491 0.0005
GSE53622 SETD2 29072 16770 -0.5177 0.0000
GSE53624 SETD2 29072 16770 -0.4477 0.0000
GSE63941 SETD2 29072 212493_s_at -0.0132 0.9627
GSE77861 SETD2 29072 215038_s_at -0.0612 0.7252
GSE97050 SETD2 29072 A_23_P44760 -0.5541 0.1065
SRP007169 SETD2 29072 RNAseq -0.2038 0.5732
SRP008496 SETD2 29072 RNAseq -0.1571 0.4239
SRP064894 SETD2 29072 RNAseq -0.5749 0.0085
SRP133303 SETD2 29072 RNAseq -0.4312 0.0000
SRP159526 SETD2 29072 RNAseq -0.5205 0.0008
SRP193095 SETD2 29072 RNAseq -0.4297 0.0000
SRP219564 SETD2 29072 RNAseq -0.4398 0.1125
TCGA SETD2 29072 RNAseq -0.1448 0.0007

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SETD2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SETD2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SETD2 29072 0 18 12
GSE20123 SETD2 29072 0 19 11
GSE43470 SETD2 29072 0 19 24
GSE46452 SETD2 29072 2 17 40
GSE47630 SETD2 29072 2 23 15
GSE54993 SETD2 29072 7 2 61
GSE54994 SETD2 29072 0 36 17
GSE60625 SETD2 29072 5 0 6
GSE74703 SETD2 29072 0 15 21
GSE74704 SETD2 29072 0 12 8
TCGA SETD2 29072 1 75 20

Total number of gains: 17; Total number of losses: 236; Total Number of normals: 235.  

 

Somatic mutations of SETD2:

 

Generating mutation plots.

 

Highly correlated genes for SETD2:

 

Showing top 20/529 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SETD2AGTPBP10.830806303
SETD2CDKL10.776098303
SETD2KLHDC10.772543303
SETD2NMNAT10.738521303
SETD2SUGT10.73059303
SETD2CLEC3B0.729678303
SETD2C11orf490.728147303
SETD2DYNC2H10.725637303
SETD2CYB5D10.724659303
SETD2KLHL150.723012303
SETD2PDS5B0.720607303
SETD2FYCO10.714319605
SETD2PBX20.711631303
SETD2FBXO80.70838303
SETD2ARL6IP50.700087605
SETD2POLK0.698401303
SETD2AP3S10.698065303
SETD2SACM1L0.697858807
SETD2KATNA10.697347303
SETD2AK40.697227303

For details and further investigation, click here