| Full name: ribonuclease A family member 4 | Alias Symbol: RAB1 | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 6038 | HGNC ID: HGNC:10047 | Ensembl Gene: ENSG00000258818 | OMIM ID: 601030 |
| Drug and gene relationship at DGIdb | |||
Expression of RNASE4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RNASE4 | 6038 | 205158_at | -1.4888 | 0.1270 | |
| GSE20347 | RNASE4 | 6038 | 205158_at | -0.3363 | 0.0099 | |
| GSE23400 | RNASE4 | 6038 | 205158_at | -0.6252 | 0.0000 | |
| GSE26886 | RNASE4 | 6038 | 205158_at | -0.3111 | 0.2275 | |
| GSE29001 | RNASE4 | 6038 | 205158_at | -0.0007 | 0.9957 | |
| GSE38129 | RNASE4 | 6038 | 205158_at | -0.9917 | 0.0233 | |
| GSE45670 | RNASE4 | 6038 | 205158_at | -2.6928 | 0.0000 | |
| GSE63941 | RNASE4 | 6038 | 205158_at | -2.1659 | 0.0424 | |
| GSE77861 | RNASE4 | 6038 | 205158_at | 0.1945 | 0.7607 | |
| GSE97050 | RNASE4 | 6038 | A_23_P205531 | -0.9638 | 0.1126 | |
| SRP007169 | RNASE4 | 6038 | RNAseq | -0.2569 | 0.6791 | |
| SRP064894 | RNASE4 | 6038 | RNAseq | -1.4078 | 0.0007 | |
| SRP133303 | RNASE4 | 6038 | RNAseq | -1.0859 | 0.0001 | |
| SRP159526 | RNASE4 | 6038 | RNAseq | -0.8547 | 0.0299 | |
| SRP193095 | RNASE4 | 6038 | RNAseq | -1.6565 | 0.0013 | |
| SRP219564 | RNASE4 | 6038 | RNAseq | -0.6890 | 0.3082 | |
| TCGA | RNASE4 | 6038 | RNAseq | -1.0753 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by RNASE4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of RNASE4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RNASE4 | 6038 | 9 | 3 | 18 | |
| GSE20123 | RNASE4 | 6038 | 8 | 3 | 19 | |
| GSE43470 | RNASE4 | 6038 | 7 | 1 | 35 | |
| GSE46452 | RNASE4 | 6038 | 19 | 2 | 38 | |
| GSE47630 | RNASE4 | 6038 | 10 | 10 | 20 | |
| GSE54993 | RNASE4 | 6038 | 3 | 11 | 56 | |
| GSE54994 | RNASE4 | 6038 | 17 | 5 | 31 | |
| GSE60625 | RNASE4 | 6038 | 0 | 2 | 9 | |
| GSE74703 | RNASE4 | 6038 | 6 | 1 | 29 | |
| GSE74704 | RNASE4 | 6038 | 4 | 2 | 14 | |
| TCGA | RNASE4 | 6038 | 28 | 16 | 52 |
Total number of gains: 111; Total number of losses: 56; Total Number of normals: 321.
Somatic mutations of RNASE4:
Generating mutation plots.
Highly correlated genes for RNASE4:
Showing top 20/1015 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RNASE4 | RASSF3 | 0.875385 | 3 | 0 | 3 |
| RNASE4 | C3orf70 | 0.839701 | 3 | 0 | 3 |
| RNASE4 | PDK2 | 0.83885 | 3 | 0 | 3 |
| RNASE4 | RGS7BP | 0.823171 | 3 | 0 | 3 |
| RNASE4 | SLIT2 | 0.817791 | 5 | 0 | 5 |
| RNASE4 | C1QTNF7 | 0.808877 | 4 | 0 | 4 |
| RNASE4 | XKR4 | 0.803302 | 3 | 0 | 3 |
| RNASE4 | FILIP1 | 0.802888 | 4 | 0 | 4 |
| RNASE4 | C9orf47 | 0.802008 | 3 | 0 | 3 |
| RNASE4 | RELN | 0.801291 | 4 | 0 | 4 |
| RNASE4 | RERGL | 0.797244 | 5 | 0 | 5 |
| RNASE4 | ANG | 0.79528 | 10 | 0 | 10 |
| RNASE4 | EBF3 | 0.79292 | 3 | 0 | 3 |
| RNASE4 | LMO3 | 0.790424 | 5 | 0 | 5 |
| RNASE4 | CD34 | 0.789617 | 5 | 0 | 5 |
| RNASE4 | EPB41L2 | 0.786261 | 5 | 0 | 5 |
| RNASE4 | ANGPTL1 | 0.783293 | 4 | 0 | 4 |
| RNASE4 | EPDR1 | 0.78038 | 3 | 0 | 3 |
| RNASE4 | ZBTB26 | 0.780096 | 3 | 0 | 3 |
| RNASE4 | HOXA4 | 0.779186 | 6 | 0 | 6 |
For details and further investigation, click here
