| Full name: RAB27A, member RAS oncogene family | Alias Symbol: RAB27|RAM|GS2|HsT18676 | ||
| Type: protein-coding gene | Cytoband: 15q21.3 | ||
| Entrez ID: 5873 | HGNC ID: HGNC:9766 | Ensembl Gene: ENSG00000069974 | OMIM ID: 603868 |
| Drug and gene relationship at DGIdb | |||
Expression of RAB27A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAB27A | 5873 | 210951_x_at | -0.3683 | 0.5230 | |
| GSE20347 | RAB27A | 5873 | 209515_s_at | -0.6438 | 0.0041 | |
| GSE23400 | RAB27A | 5873 | 210951_x_at | -0.4557 | 0.0000 | |
| GSE26886 | RAB27A | 5873 | 210951_x_at | -1.0187 | 0.0007 | |
| GSE29001 | RAB27A | 5873 | 210951_x_at | -0.6708 | 0.0118 | |
| GSE38129 | RAB27A | 5873 | 209515_s_at | -0.7812 | 0.0000 | |
| GSE45670 | RAB27A | 5873 | 210951_x_at | 0.1564 | 0.4957 | |
| GSE53622 | RAB27A | 5873 | 67349 | -0.4749 | 0.0000 | |
| GSE53624 | RAB27A | 5873 | 67349 | -0.9805 | 0.0000 | |
| GSE63941 | RAB27A | 5873 | 210951_x_at | 0.3453 | 0.5875 | |
| GSE77861 | RAB27A | 5873 | 209514_s_at | -0.7502 | 0.0035 | |
| GSE97050 | RAB27A | 5873 | A_24_P373174 | -0.2308 | 0.3781 | |
| SRP007169 | RAB27A | 5873 | RNAseq | -1.9874 | 0.0000 | |
| SRP008496 | RAB27A | 5873 | RNAseq | -1.5872 | 0.0000 | |
| SRP064894 | RAB27A | 5873 | RNAseq | -0.4105 | 0.0268 | |
| SRP133303 | RAB27A | 5873 | RNAseq | -0.0889 | 0.6138 | |
| SRP159526 | RAB27A | 5873 | RNAseq | -0.8736 | 0.0166 | |
| SRP193095 | RAB27A | 5873 | RNAseq | -0.6437 | 0.0113 | |
| SRP219564 | RAB27A | 5873 | RNAseq | -0.2538 | 0.4062 | |
| TCGA | RAB27A | 5873 | RNAseq | -0.5943 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by RAB27A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAB27A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAB27A | 5873 | 6 | 3 | 21 | |
| GSE20123 | RAB27A | 5873 | 6 | 3 | 21 | |
| GSE43470 | RAB27A | 5873 | 4 | 3 | 36 | |
| GSE46452 | RAB27A | 5873 | 3 | 7 | 49 | |
| GSE47630 | RAB27A | 5873 | 8 | 10 | 22 | |
| GSE54993 | RAB27A | 5873 | 5 | 6 | 59 | |
| GSE54994 | RAB27A | 5873 | 5 | 8 | 40 | |
| GSE60625 | RAB27A | 5873 | 4 | 0 | 7 | |
| GSE74703 | RAB27A | 5873 | 4 | 2 | 30 | |
| GSE74704 | RAB27A | 5873 | 2 | 3 | 15 | |
| TCGA | RAB27A | 5873 | 10 | 16 | 70 |
Total number of gains: 57; Total number of losses: 61; Total Number of normals: 370.
Somatic mutations of RAB27A:
Generating mutation plots.
Highly correlated genes for RAB27A:
Showing top 20/1015 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAB27A | RBM20 | 0.787769 | 3 | 0 | 3 |
| RAB27A | USP54 | 0.784926 | 3 | 0 | 3 |
| RAB27A | HDHD2 | 0.780235 | 3 | 0 | 3 |
| RAB27A | OPHN1 | 0.767228 | 4 | 0 | 4 |
| RAB27A | ZNF844 | 0.762493 | 3 | 0 | 3 |
| RAB27A | ITGAD | 0.759753 | 3 | 0 | 3 |
| RAB27A | NACA2 | 0.758973 | 3 | 0 | 3 |
| RAB27A | PITHD1 | 0.749356 | 4 | 0 | 4 |
| RAB27A | TMEM234 | 0.739688 | 3 | 0 | 3 |
| RAB27A | GIMAP5 | 0.730117 | 3 | 0 | 3 |
| RAB27A | RCSD1 | 0.729576 | 3 | 0 | 3 |
| RAB27A | TMEM61 | 0.727763 | 3 | 0 | 3 |
| RAB27A | IGIP | 0.719051 | 3 | 0 | 3 |
| RAB27A | ARFGEF2 | 0.715838 | 3 | 0 | 3 |
| RAB27A | ATP13A4 | 0.714823 | 3 | 0 | 3 |
| RAB27A | RNGTT | 0.710822 | 4 | 0 | 4 |
| RAB27A | SLC46A2 | 0.710058 | 5 | 0 | 4 |
| RAB27A | ARG2 | 0.708807 | 4 | 0 | 4 |
| RAB27A | ZFAND2B | 0.708037 | 3 | 0 | 3 |
| RAB27A | KLHDC1 | 0.704948 | 3 | 0 | 3 |
For details and further investigation, click here
